TY - JOUR
T1 - Estimating a drug’s elimination rate-constant or half-life from a single blood sample
T2 - A practical approach with particular benefits for critically ill/vulnerable patients
AU - Scutt, Greg
AU - Allen, Marcus
AU - Waxman, David
PY - 2019/7/29
Y1 - 2019/7/29
N2 - In this paper we present a mathematical solution that allows the elimination rate-constant or half life of a drug to be estimated from a single blood drug measurement. This is of great utility in clinical areas involving care of criticallly ill or vulnerable patients, where providing more than one blood sample can involve significant risks. The calculations used in our approach, based solely on a single sample, do not require complex pharmacokinetic software, but instead can be simply performed at the patient’s bedside using standard personal computing tools. The proposed method allows a personalised estimate of the drug’s half life, which is preferable to using population averages, or using estimates based on proxy markers of lagging organ function, which are both indirect and generally inaccurate for a patient with confounding factors.
AB - In this paper we present a mathematical solution that allows the elimination rate-constant or half life of a drug to be estimated from a single blood drug measurement. This is of great utility in clinical areas involving care of criticallly ill or vulnerable patients, where providing more than one blood sample can involve significant risks. The calculations used in our approach, based solely on a single sample, do not require complex pharmacokinetic software, but instead can be simply performed at the patient’s bedside using standard personal computing tools. The proposed method allows a personalised estimate of the drug’s half life, which is preferable to using population averages, or using estimates based on proxy markers of lagging organ function, which are both indirect and generally inaccurate for a patient with confounding factors.
KW - Mathematical models
KW - Personalised medicine
KW - Pharmacokinetics
KW - Steady state and transient drug concentration
KW - Therapeutic drug monitoring
UR - http://www.scopus.com/inward/record.url?scp=85071941343&partnerID=8YFLogxK
U2 - 10.1016/j.biosystems.2019.103996
DO - 10.1016/j.biosystems.2019.103996
M3 - Article
SN - 0303-2647
VL - 184
JO - BioSystems
JF - BioSystems
M1 - 103996
ER -