Environmental heat stress on maternal physiology and fetal blood flow in pregnant subsistence farmers in The Gambia, west Africa: an observational cohort study

Ana Bonell, Bakary Sonko, Jainaba Badjie, Tida Samateh, Tida Saidy, Fatou Sasseh, Yahya Sallah, Kebba Bajo, Kris Murray, Jane Hirst, Ana Vicedo-Cabrera, Andrew Prentice, Neil Maxwell, Andy Haines

Research output: Contribution to journalArticlepeer-review

Abstract

Background Anthropogenic climate change has caused extreme temperatures worldwide, with data showing that sub-Saharan Africa is especially vulnerable to these changes. In sub-Saharan Africa, women comprise 50% of the agricultural workforce, often working throughout pregnancy despite heat exposure increasing the risk of adverse birth outcomes. In this study, we aimed to improve understanding of the pathophysiological mechanisms responsible for the adverse health outcomes resulting from environmental heat stress in pregnant subsistence farmers. We also aimed to provide data to establish whether environmental heat stress also has physiological effects
on the fetus.

Methods We conducted an observational cohort study in West Kiang, The Gambia, at the field station for the Medical Research Council Unit The Gambia at London School of Hygiene & Tropical Medicine (named the MRC Keneba field
station). Pregnant women who were aged 16 years or older and who were at manual daily tasks of living. Participants were ineligible if they refused to provide consent, had multiple pregnancies (eg, if they had twins), were acutely unwell, or were diagnosed with pre-eclampsia or eclampsia. Heat stress was
measured by wet bulb globe temperature (WBGT) and by using the universal thermal climate index (UTCI), and maternal heat strain was directly measured by modified physiological strain index calculated from heart rate and skin
temperature. Outcome measures of fetal heart rate (FHR) and fetal strain (defined as a FHR >160 beats per min [bpm] or period. Multivariable repeated measure models (linear regression for FHR, and logistic regression for fetal strain) were used to evaluate the association of heat stress and heat strain with acute fetal strain.

Findings Between Aug 26, 2019, and March 27, 2020, 92 eligible participants were recruited to the study. Extreme heat exposure was frequent, with average exposures of WBGT of 27·2°C (SD 3·6°C) and UTCI equivalent temperature of
34·0°C (SD 3·7°C). The total effect of UTCI on fetal strain resulted in an odds ratio (OR) of 1·17 (95% CI 1·09–1·29; padjusted OR of maternal heat strain on fetal strain was 1·20 (1·01–1·43; p=0·038), using the UTCI model, with each unit increase.

Interpretation Data from our study show that decreasing maternal exposure to heat stress and heat strain is likely to reduce fetal strain, with the potential to reduce adverse birth outcomes. Further work that explores the association
between heat stress and pregnancy outcomes in a variety of settings and populations is urgently needed to develop effective interventions.
Original languageEnglish
Pages (from-to)e968-e976
Number of pages12
JournalLancet Planetary Health
Volume6
Issue number12
DOIs
Publication statusPublished - 7 Dec 2022

Bibliographical note

Funding Information:
This project was funded by the Wellcome Trust through the Wellcome Trust Global Health PhD Fellowship awarded to AB (216336/Z/19/Z). We would like to acknowledge the communities in West Kiang for their support and engagement with the project, especially the pregnant participants enrolled in the trial.

Publisher Copyright:
© 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license

Fingerprint

Dive into the research topics of 'Environmental heat stress on maternal physiology and fetal blood flow in pregnant subsistence farmers in The Gambia, west Africa: an observational cohort study'. Together they form a unique fingerprint.

Cite this