Electrochemical methods for monitoring neurotransmitter dynamics in vitro: From theory to experiments

Costas A. Anastassiou, Bhavik A. Patel, Kim H. Parker, Danny O'Hare

    Research output: Chapter in Book/Conference proceeding with ISSN or ISBNConference contribution with ISSN or ISBNpeer-review

    Abstract

    Electrochemical monitoring of neurotransmitter signaling molecules, i.e. neurotransmitters, has been often used for various biological investigations involving physiological or pathological states. In this work we introduce alternatives to conventional electrochemical bio-monitoring and study three important neurotransmitters, dopamine, serotonin and noradrenalin, in vitro using an electrochemical technique, AC voltammetry, in combination with the Hilbert transform. We show how this method overcomes the two major difficulties of electrochemical bio-sensing: capacitance influence and the inherently nonlinear behavior of electron-transfer. We illustrate how such novel methods enhance the quantity and the quality of the biological information extracted from electrochemical measurements. This study has not only implications in general biological monitoring methodologies but also in software and hardware design and micro-fabrication.

    Original languageEnglish
    Title of host publicationProceedings - BSN 2006
    Subtitle of host publicationInternational Workshop on Wearable and Implantable Body Sensor Networks
    Pages96-99
    Number of pages4
    Volume2006
    DOIs
    Publication statusPublished - 14 Nov 2006
    EventBSN 2006: International Workshop on Wearable and Implantable Body Sensor Networks - Cambridge, MA, United States
    Duration: 3 Apr 20065 Apr 2006

    Workshop

    WorkshopBSN 2006: International Workshop on Wearable and Implantable Body Sensor Networks
    Country/TerritoryUnited States
    CityCambridge, MA
    Period3/04/065/04/06

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