Electrochemical methods for monitoring neurotransmitter dynamics in vitro: From theory to experiments

Costas A. Anastassiou, Bhavik A. Patel, Kim H. Parker, Danny O'Hare

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNConference contribution with ISSN or ISBN

Abstract

Electrochemical monitoring of neurotransmitter signaling molecules, i.e. neurotransmitters, has been often used for various biological investigations involving physiological or pathological states. In this work we introduce alternatives to conventional electrochemical bio-monitoring and study three important neurotransmitters, dopamine, serotonin and noradrenalin, in vitro using an electrochemical technique, AC voltammetry, in combination with the Hilbert transform. We show how this method overcomes the two major difficulties of electrochemical bio-sensing: capacitance influence and the inherently nonlinear behavior of electron-transfer. We illustrate how such novel methods enhance the quantity and the quality of the biological information extracted from electrochemical measurements. This study has not only implications in general biological monitoring methodologies but also in software and hardware design and micro-fabrication.

Original languageEnglish
Title of host publicationProceedings - BSN 2006
Subtitle of host publicationInternational Workshop on Wearable and Implantable Body Sensor Networks
Pages96-99
Number of pages4
Volume2006
DOIs
Publication statusPublished - 14 Nov 2006
EventBSN 2006: International Workshop on Wearable and Implantable Body Sensor Networks - Cambridge, MA, United States
Duration: 3 Apr 20065 Apr 2006

Workshop

WorkshopBSN 2006: International Workshop on Wearable and Implantable Body Sensor Networks
CountryUnited States
CityCambridge, MA
Period3/04/065/04/06

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    Anastassiou, C. A., Patel, B. A., Parker, K. H., & O'Hare, D. (2006). Electrochemical methods for monitoring neurotransmitter dynamics in vitro: From theory to experiments. In Proceedings - BSN 2006: International Workshop on Wearable and Implantable Body Sensor Networks (Vol. 2006, pp. 96-99). [1612905] https://doi.org/10.1109/BSN.2006.23