Effects of exercise-induced arterial hypoxaemia and work rate on diaphragmatic fatigue in highly trained endurance athletes

Ioannis Vogiatzis, Olga Georgiadou, Ifigenia Giannopoulou, Maria Koskolou, Spyros Zakynthinos, Konstantinos Kostikas, Epaminondas Kosmas, Harrieth Wagner, Eleni Peraki, Antonia Koutsoukou, Nickolaos Koulouris, Peter D. Wagner, Charis Roussos

Research output: Contribution to journalArticle

Abstract

Diaphragmatic fatigue occurs in highly trained athletes during exhaustive exercise. Since approximately half of them also exhibit exercise-induced arterial hypoxaemia (EIAH) during high-intensity exercise, the present study sought to test the hypothesis that arterial hypoxaemia contributes to exercise-induced diaphragmatic fatigue in this population. Ten cyclists (: 70.0 ± 1.6 ml kg−1min−1; mean ±s.e.m.) completed, in a balanced ordering sequence, one normoxic (end-exercise arterial O2saturation(S): 92 ± 1%) and one hyperoxic (F: 0.5% O2;S: 97 ± 1%) 5 min exercise test at intensities equal to 80 ± 3 and 90 ± 3% of maximal work rate (WRmax), respectively, producing the same tidal volume (VT) and breathing frequency (f) throughout exercise. Cervical magnetic stimulation was used to determine reduction in twitch transdiaphragmatic pressure (Pdi,tw) during recovery. Hyperoxic exercise at 90% WRmaxinduced significantly (P= 0.022) greater post-exercise reduction inPdi,tw(15 ± 2%) than did normoxic exercise at 80% WRmax(9 ± 2%), despite the similar mean ventilation (123 ± 8 and 119 ± 8 l min−1, respectively), breathing pattern (VT: 2.53 ± 0.05 and 2.61 ± 0.05 l,f: 49 ± 2 and 46 ± 2 breaths min−1, respectively), mean changes inPdiduring exercise (37.1 ± 2.4 and 38.2 ± 2.8 cmH2O, respectively) and end-exercise arterial lactate (12.1 ± 1.4 and 10.8 ± 1.1 mmol l−1, respectively). The difference found in diaphragmatic fatigue between the hyperoxic (at higher leg work rate) and the normoxic (at lower leg work rate) tests suggests that neither EIAH nor lactic acidosisper seare likely predominant causative factors in diaphragmatic fatigue in this population, at least at the level ofStested. Rather, this result leads us to hypothesize that blood flow competition with the legs is an important contributor to diaphragmatic fatigue in heavy exercise, assuming that higher leg work required greater leg blood flow.
Original languageEnglish
Pages (from-to)539-549
Number of pages11
JournalJournal of Physiology
Volume572
Issue number2
DOIs
Publication statusPublished - 1 Apr 2006

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    Vogiatzis, I., Georgiadou, O., Giannopoulou, I., Koskolou, M., Zakynthinos, S., Kostikas, K., Kosmas, E., Wagner, H., Peraki, E., Koutsoukou, A., Koulouris, N., Wagner, P. D., & Roussos, C. (2006). Effects of exercise-induced arterial hypoxaemia and work rate on diaphragmatic fatigue in highly trained endurance athletes. Journal of Physiology, 572(2), 539-549. https://doi.org/10.1113/jphysiol.2005.102442