Does the FTO gene interact with the socioeconomic status on the obesity development among young European children? Results from the IDEFICS study

Ronja Foraita, F. Günther, W. Gwozdz, Lucia Reisch, Paola Russo, Fabio Lauria, Alfonso Siani, Toomas Veidebaum, M. Tornaritis, Licia Iacoviello, K. Vyncke, Yannis Pitsiladis, Staffan Marild, D. Molnár, Luis A. Moreno, K. Bammann, Iris Pigeot

Research output: Contribution to journalArticle

Abstract

Background:Various twin studies revealed that the influence of genetic factors on psychological diseases or behaviour is more expressed in socioeconomically advantaged environments. Other studies predominantly show an inverse association between socioeconomic status (SES) and childhood obesity in Western developed countries. The aim of this study is to investigate whether the fat mass and obesity-associated (FTO) gene interacts with the SES on childhood obesity in a subsample (N=4406) of the IDEFICS (Identification and prevention of Dietary- and lifestyle-induced health EFfects In Children and infantS) cohort.Methods:A structural equation model (SEM) is applied with the latent constructs obesity, dietary intakes, physical activity and fitness habits, and parental SES to estimate the main effects of the latter three variables and a FTO polymorphism on childhood obesity. Further, a multiple group SEM is used to explore whether an interaction effect exists between the single nucleotide polymorphism rs9939609 within the FTO gene and SES.Results:Significant main effects are shown for physical activity and fitness (standardised [betacrc ]s= -0.113), SES ([betacrc ]s= -0.057) and the FTO homozygous AA risk genotype ([betacrc ]s= -0.177). The explained variance of obesity is ~9%. According to the multiple group approach of SEM, we see an interaction between SES and FTO with respect to their effect on childhood obesity (Δχ2=7.3, df=2, P=0.03).Conclusion:Children carrying the protective FTO genotype TT seem to be more protected by a favourable social environment regarding the development of obesity than children carrying the AT or AA genotype.
Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalInternational Journal of Obesity
Volume39
DOIs
Publication statusPublished - 1 Jan 2015

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Social Class
Obesity
Fats
Pediatric Obesity
Genes
Structural Models
Physical Fitness
Genotype
Exercise
Twin Studies
Social Environment
Child Development
Developed Countries
Habits
Single Nucleotide Polymorphism
Life Style
Psychology
Health

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Foraita, Ronja ; Günther, F. ; Gwozdz, W. ; Reisch, Lucia ; Russo, Paola ; Lauria, Fabio ; Siani, Alfonso ; Veidebaum, Toomas ; Tornaritis, M. ; Iacoviello, Licia ; Vyncke, K. ; Pitsiladis, Yannis ; Marild, Staffan ; Molnár, D. ; Moreno, Luis A. ; Bammann, K. ; Pigeot, Iris. / Does the FTO gene interact with the socioeconomic status on the obesity development among young European children? Results from the IDEFICS study. In: International Journal of Obesity. 2015 ; Vol. 39. pp. 1-6.
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title = "Does the FTO gene interact with the socioeconomic status on the obesity development among young European children? Results from the IDEFICS study",
abstract = "Background:Various twin studies revealed that the influence of genetic factors on psychological diseases or behaviour is more expressed in socioeconomically advantaged environments. Other studies predominantly show an inverse association between socioeconomic status (SES) and childhood obesity in Western developed countries. The aim of this study is to investigate whether the fat mass and obesity-associated (FTO) gene interacts with the SES on childhood obesity in a subsample (N=4406) of the IDEFICS (Identification and prevention of Dietary- and lifestyle-induced health EFfects In Children and infantS) cohort.Methods:A structural equation model (SEM) is applied with the latent constructs obesity, dietary intakes, physical activity and fitness habits, and parental SES to estimate the main effects of the latter three variables and a FTO polymorphism on childhood obesity. Further, a multiple group SEM is used to explore whether an interaction effect exists between the single nucleotide polymorphism rs9939609 within the FTO gene and SES.Results:Significant main effects are shown for physical activity and fitness (standardised [betacrc ]s= -0.113), SES ([betacrc ]s= -0.057) and the FTO homozygous AA risk genotype ([betacrc ]s= -0.177). The explained variance of obesity is ~9{\%}. According to the multiple group approach of SEM, we see an interaction between SES and FTO with respect to their effect on childhood obesity (Δχ2=7.3, df=2, P=0.03).Conclusion:Children carrying the protective FTO genotype TT seem to be more protected by a favourable social environment regarding the development of obesity than children carrying the AT or AA genotype.",
author = "Ronja Foraita and F. G{\"u}nther and W. Gwozdz and Lucia Reisch and Paola Russo and Fabio Lauria and Alfonso Siani and Toomas Veidebaum and M. Tornaritis and Licia Iacoviello and K. Vyncke and Yannis Pitsiladis and Staffan Marild and D. Moln{\'a}r and Moreno, {Luis A.} and K. Bammann and Iris Pigeot",
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Foraita, R, Günther, F, Gwozdz, W, Reisch, L, Russo, P, Lauria, F, Siani, A, Veidebaum, T, Tornaritis, M, Iacoviello, L, Vyncke, K, Pitsiladis, Y, Marild, S, Molnár, D, Moreno, LA, Bammann, K & Pigeot, I 2015, 'Does the FTO gene interact with the socioeconomic status on the obesity development among young European children? Results from the IDEFICS study', International Journal of Obesity, vol. 39, pp. 1-6. https://doi.org/10.1038/ijo.2014.156

Does the FTO gene interact with the socioeconomic status on the obesity development among young European children? Results from the IDEFICS study. / Foraita, Ronja; Günther, F.; Gwozdz, W.; Reisch, Lucia; Russo, Paola; Lauria, Fabio; Siani, Alfonso; Veidebaum, Toomas; Tornaritis, M.; Iacoviello, Licia; Vyncke, K.; Pitsiladis, Yannis; Marild, Staffan; Molnár, D.; Moreno, Luis A.; Bammann, K.; Pigeot, Iris.

In: International Journal of Obesity, Vol. 39, 01.01.2015, p. 1-6.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Does the FTO gene interact with the socioeconomic status on the obesity development among young European children? Results from the IDEFICS study

AU - Foraita, Ronja

AU - Günther, F.

AU - Gwozdz, W.

AU - Reisch, Lucia

AU - Russo, Paola

AU - Lauria, Fabio

AU - Siani, Alfonso

AU - Veidebaum, Toomas

AU - Tornaritis, M.

AU - Iacoviello, Licia

AU - Vyncke, K.

AU - Pitsiladis, Yannis

AU - Marild, Staffan

AU - Molnár, D.

AU - Moreno, Luis A.

AU - Bammann, K.

AU - Pigeot, Iris

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Background:Various twin studies revealed that the influence of genetic factors on psychological diseases or behaviour is more expressed in socioeconomically advantaged environments. Other studies predominantly show an inverse association between socioeconomic status (SES) and childhood obesity in Western developed countries. The aim of this study is to investigate whether the fat mass and obesity-associated (FTO) gene interacts with the SES on childhood obesity in a subsample (N=4406) of the IDEFICS (Identification and prevention of Dietary- and lifestyle-induced health EFfects In Children and infantS) cohort.Methods:A structural equation model (SEM) is applied with the latent constructs obesity, dietary intakes, physical activity and fitness habits, and parental SES to estimate the main effects of the latter three variables and a FTO polymorphism on childhood obesity. Further, a multiple group SEM is used to explore whether an interaction effect exists between the single nucleotide polymorphism rs9939609 within the FTO gene and SES.Results:Significant main effects are shown for physical activity and fitness (standardised [betacrc ]s= -0.113), SES ([betacrc ]s= -0.057) and the FTO homozygous AA risk genotype ([betacrc ]s= -0.177). The explained variance of obesity is ~9%. According to the multiple group approach of SEM, we see an interaction between SES and FTO with respect to their effect on childhood obesity (Δχ2=7.3, df=2, P=0.03).Conclusion:Children carrying the protective FTO genotype TT seem to be more protected by a favourable social environment regarding the development of obesity than children carrying the AT or AA genotype.

AB - Background:Various twin studies revealed that the influence of genetic factors on psychological diseases or behaviour is more expressed in socioeconomically advantaged environments. Other studies predominantly show an inverse association between socioeconomic status (SES) and childhood obesity in Western developed countries. The aim of this study is to investigate whether the fat mass and obesity-associated (FTO) gene interacts with the SES on childhood obesity in a subsample (N=4406) of the IDEFICS (Identification and prevention of Dietary- and lifestyle-induced health EFfects In Children and infantS) cohort.Methods:A structural equation model (SEM) is applied with the latent constructs obesity, dietary intakes, physical activity and fitness habits, and parental SES to estimate the main effects of the latter three variables and a FTO polymorphism on childhood obesity. Further, a multiple group SEM is used to explore whether an interaction effect exists between the single nucleotide polymorphism rs9939609 within the FTO gene and SES.Results:Significant main effects are shown for physical activity and fitness (standardised [betacrc ]s= -0.113), SES ([betacrc ]s= -0.057) and the FTO homozygous AA risk genotype ([betacrc ]s= -0.177). The explained variance of obesity is ~9%. According to the multiple group approach of SEM, we see an interaction between SES and FTO with respect to their effect on childhood obesity (Δχ2=7.3, df=2, P=0.03).Conclusion:Children carrying the protective FTO genotype TT seem to be more protected by a favourable social environment regarding the development of obesity than children carrying the AT or AA genotype.

U2 - 10.1038/ijo.2014.156

DO - 10.1038/ijo.2014.156

M3 - Article

VL - 39

SP - 1

EP - 6

JO - International Journal of Obesity

JF - International Journal of Obesity

SN - 0307-0565

ER -