Does the cochlea compromise on sensitivity and frequency selectivity?

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNConference contribution with ISSN or ISBN

Abstract

A tenet of cochlear physiology is that sharp tuning and sensitivity are directly interrelated. Here we show a reciprocal interdependence between tuning and sensitivity in the mammalian cochlea from measurements of basilar membrane (BM) mechanical tuning and neural suppression tuning curves of wild-type (Tectb+/+) and β-tectorin mutant (Tectb-/-) mice. The tectorial membrane (TM) of the mutants lacks striated-sheet matrix, which is likely to decrease longitudinal elastic coupling. Mechanical and neural tuning curves recorded in mutants are slightly less sensitive, although more sharply tuned. The inverse relationship between sensitivity and tuning observed in the mutants could be attributed to smaller numbers of the outer hair cells responding in synchrony due to reduced longitudinal coupling in the TM. We suggest that frequency tuning and high sensitivity are not necessarily concomitant but reciprocal properties of the cochlea.

Original languageEnglish
Title of host publicationConcepts and Challenges in the Biophysics of Hearing - Proceedings of the 10th International Workshop on the Mechanics of Hearing, MoH 2008
EditorsDavid T. Kemp, Nigel P. Cooper
PublisherWorld Scientific Publishing Co. Pte Ltd
Pages141-147
Number of pages7
ISBN (Electronic)9789812833778
Publication statusPublished - 1 Jan 2008
Event10th International Workshop on the Mechanics of Hearing - Concepts and Challenges in the Biophysics of Hearing, MoH 2008 - Newcastle, United Kingdom
Duration: 27 Jul 200831 Jul 2008

Publication series

NameConcepts and Challenges in the Biophysics of Hearing - Proceedings of the 10th International Workshop on the Mechanics of Hearing, MoH 2008

Conference

Conference10th International Workshop on the Mechanics of Hearing - Concepts and Challenges in the Biophysics of Hearing, MoH 2008
CountryUnited Kingdom
CityNewcastle
Period27/07/0831/07/08

Fingerprint

Cochlea
Tectorial Membrane
Tuning
Outer Auditory Hair Cells
Basilar Membrane
Membranes
Physiology
Cells

Cite this

Lukashkin, A. N., Lukashkina, V. A., Richardson, G. P., & Russell, I. J. (2008). Does the cochlea compromise on sensitivity and frequency selectivity? In D. T. Kemp, & N. P. Cooper (Eds.), Concepts and Challenges in the Biophysics of Hearing - Proceedings of the 10th International Workshop on the Mechanics of Hearing, MoH 2008 (pp. 141-147). (Concepts and Challenges in the Biophysics of Hearing - Proceedings of the 10th International Workshop on the Mechanics of Hearing, MoH 2008). World Scientific Publishing Co. Pte Ltd.
Lukashkin, A. N. ; Lukashkina, V. A. ; Richardson, G. P. ; Russell, I. J. / Does the cochlea compromise on sensitivity and frequency selectivity?. Concepts and Challenges in the Biophysics of Hearing - Proceedings of the 10th International Workshop on the Mechanics of Hearing, MoH 2008. editor / David T. Kemp ; Nigel P. Cooper. World Scientific Publishing Co. Pte Ltd, 2008. pp. 141-147 (Concepts and Challenges in the Biophysics of Hearing - Proceedings of the 10th International Workshop on the Mechanics of Hearing, MoH 2008).
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Lukashkin, AN, Lukashkina, VA, Richardson, GP & Russell, IJ 2008, Does the cochlea compromise on sensitivity and frequency selectivity? in DT Kemp & NP Cooper (eds), Concepts and Challenges in the Biophysics of Hearing - Proceedings of the 10th International Workshop on the Mechanics of Hearing, MoH 2008. Concepts and Challenges in the Biophysics of Hearing - Proceedings of the 10th International Workshop on the Mechanics of Hearing, MoH 2008, World Scientific Publishing Co. Pte Ltd, pp. 141-147, 10th International Workshop on the Mechanics of Hearing - Concepts and Challenges in the Biophysics of Hearing, MoH 2008, Newcastle, United Kingdom, 27/07/08.

Does the cochlea compromise on sensitivity and frequency selectivity? / Lukashkin, A. N.; Lukashkina, V. A.; Richardson, G. P.; Russell, I. J.

Concepts and Challenges in the Biophysics of Hearing - Proceedings of the 10th International Workshop on the Mechanics of Hearing, MoH 2008. ed. / David T. Kemp; Nigel P. Cooper. World Scientific Publishing Co. Pte Ltd, 2008. p. 141-147 (Concepts and Challenges in the Biophysics of Hearing - Proceedings of the 10th International Workshop on the Mechanics of Hearing, MoH 2008).

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNConference contribution with ISSN or ISBN

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AB - A tenet of cochlear physiology is that sharp tuning and sensitivity are directly interrelated. Here we show a reciprocal interdependence between tuning and sensitivity in the mammalian cochlea from measurements of basilar membrane (BM) mechanical tuning and neural suppression tuning curves of wild-type (Tectb+/+) and β-tectorin mutant (Tectb-/-) mice. The tectorial membrane (TM) of the mutants lacks striated-sheet matrix, which is likely to decrease longitudinal elastic coupling. Mechanical and neural tuning curves recorded in mutants are slightly less sensitive, although more sharply tuned. The inverse relationship between sensitivity and tuning observed in the mutants could be attributed to smaller numbers of the outer hair cells responding in synchrony due to reduced longitudinal coupling in the TM. We suggest that frequency tuning and high sensitivity are not necessarily concomitant but reciprocal properties of the cochlea.

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Lukashkin AN, Lukashkina VA, Richardson GP, Russell IJ. Does the cochlea compromise on sensitivity and frequency selectivity? In Kemp DT, Cooper NP, editors, Concepts and Challenges in the Biophysics of Hearing - Proceedings of the 10th International Workshop on the Mechanics of Hearing, MoH 2008. World Scientific Publishing Co. Pte Ltd. 2008. p. 141-147. (Concepts and Challenges in the Biophysics of Hearing - Proceedings of the 10th International Workshop on the Mechanics of Hearing, MoH 2008).