DNA damage as a result of psychological stress: implications for breast cancer

Melanie Flint, Dana H. Bovbjerg

Research output: Contribution to journalArticle

Abstract

Accumulating evidence indicates that psychological stress can have deleterious influences on cancer development and progression, but the mechanisms responsible remain unclear. One possible mechanism is suggested by emerging evidence that DNA damage is increased by exposure to stress and stress hormones (for example, cortisol, catecholamines). Possible molecular mechanisms for such effects were the subject of a recent paper by Hara and colleagues, which suggests that chronic stress, through β-adrenergic stimulation, can induce two synergistic pathways that result in accumulation of DNA damage. Herein, we discuss the potential implications of these findings for breast cancer etiology, progression, and treatment response.
Original languageEnglish
Pages (from-to)320
JournalBreast Cancer Research
Volume14
Issue number5
DOIs
Publication statusPublished - 31 Dec 2012

Bibliographical note

© 2012 BioMed Central Ltd

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