Differentially instructive extracellular protein micro-nets

Nilofar Faruqui, Angelo Bella, Jascindra Ravi, Santanu Ray, Baptiste Lamarre, Maxim G. Ryadnov

Research output: Contribution to journalArticlepeer-review

Abstract

An ability to construct biological matter from the molecule up holds promise for applications ranging from smart materials to integrated biophysical models for synthetic biology. Biomolecular self-assembly is an efficient strategy for biomaterial construction which can be programmed to support desired function. A challenge remains in replicating the strategy synthetically, that is at will, and differentially, that is for a specific function at a given length scale. Here we introduce a self-assembly topology enabling a net-like architectural mimetic of native extracellular matrices capable of differential responses to cell adhesion-enhanced mammalian cell attachment and proliferation, and enhanced resistance to bacterial colonization-at the native sub-millimeter length scales. The biological performance of such protein micro-nets directly correlates with their morphological and chemical properties, offering thus an application model for differential extracellular matrices.

Original languageEnglish
Pages (from-to)7889-7898
Number of pages10
JournalJournal of the American Chemical Society
Volume136
Issue number22
DOIs
Publication statusPublished - 13 May 2014

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