Development of Cu-Modified PVC and PU for Catalytic Generation of Nitric Oxide

Liana Azizova, Santanu Ray, Sergey Mikhalovsky, Lyuba Mikhalovska

Research output: Contribution to journalArticle

Abstract

Nitric oxide (NO) generating surfaces are potentially promising for improving haemocompatibility of blood-contacting biomaterials. In the present report, Cu-modified poly(vinyl chloride) (PVC) and polyurethane (PU) were prepared via polydopamine (pDA)-assisted chelation. The copper content on the PVC and PU modified surfaces, assessed by inductively coupled plasma - optical emission spectrometry (ICP-OES), were about 3.86 and 6.04 nmol·cm−2, respectively. The Fourier-transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS) data suggest that copper is attached to the polymer surface through complex formation with pDA. The cumulative leaching of copper from modified PVC and PU during the five day incubation in phosphate buffered saline (PBS), measured by inductively coupled plasma mass spectrometry (ICP-MS), was about 50.7 ppb and 48 ppb, respectively which is within its physiological level. Modified polymers were tested for their ability to catalytically generate NO by decomposing of endogenous S-nitrosothiol (GSNO). The obtained data show that Cu-modified PVC and PU exhibited the capacity to generate physiological levels of NO which could be a foundation for developing new biocompatible materials with NO-based therapeutics.
Original languageEnglish
Pages (from-to)20-33
Number of pages13
JournalColloids and Interfaces
Volume3
Issue number1
DOIs
Publication statusPublished - 9 Mar 2019

Bibliographical note

©2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

Keywords

  • nitric oxide
  • S-nitrosothiol (GSNO)
  • copper
  • polydopamine
  • poly(vinyl chloride) (PVC)
  • polyurethane (PU)

Fingerprint Dive into the research topics of 'Development of Cu-Modified PVC and PU for Catalytic Generation of Nitric Oxide'. Together they form a unique fingerprint.

  • Equipment

  • Cite this