Determination of bromate in drinking water by ultraperformance liquid chromatography–tandem mass spectrometry

Ibrahim Hotan Alsohaimi, Zeid Abdullah Alothman, Mohammad Rizwan Khan, Mohammad Abulhassan Abdalla, Rosa Busquets Santacana, Ahmad Khodran Alomary

Research output: Contribution to journalArticlepeer-review


Bromate (BrO3 –) is a by–product formed as a result of disinfection of bromide–containing source waters with ozone or hypochlorite. The determination of this disinfection by–product in drinking water is important since it has been recognized as a possible human carcinogen by the International Agency for Research on Cancer. In present work, a sensitive and fast analysis of bromate in drinking water has been developed based on reversed phased ultra–performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS). The quality parameters of the developed method were established, obtaining very low instrumental limit of detection (0.01 ng·ml–1), run–to–run and day–to–day precisions with RSD <3% when analyzing a bromate standard at 0.05 Hg·ml−1 with analysis time of only 0.4 min. The developed analytical method was applied for the analysis of metropolitan and bottled water from the Kingdom of Saudi Arabia; a total of 22 samples have been analyzed. Bromate was detected in the metropolitan water samples (from desalinization source) at concentrations ranging between 3.43 and 75.04 ng·ml–1 and in the bottled water samples at concentrations ranging between 2.07 and 21.90 ng·ml–1. Moreover, in comparison to established analytical methods such as liquid chromatography–tandem mass spectrometry, the proposed method was found to be very sensitive, selective and rapid for the routine analysis of bromate at low level in drinking water.
Original languageEnglish
Pages (from-to)2538-2543
Number of pages6
JournalJournal of Separation Science
Issue number19
Publication statusPublished - 6 Jun 2012


  • Bottled drinking water
  • Bromate
  • Metropolitan drinking water
  • Saudi Arabia
  • Ultraperformance liquid chromatography–tandem mass spectrometry


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