1,4-Dimethoxypillararene (1,4-DMPA) was incorporated into graphite-epoxy composite electrodes and shown to give an enhanced response to clinically important Na+ and K+ over other simple cations. Electrode selectivity, sensitivity, stability and reproducibility were determined. The mechanism behind selectivity was investigated using computational simulations which indicated that Li+, Rb+ and Cs+ exist as solvated cations outside, or at the opening to, the macrocycle whereas Na+ and K+ are bound within the macrocyclic cavity. Simulations suggest that 1,4-DMPA has a higher binding affinity for K+ over Na+. This was confirmed experimentally by stripping cations from the electrodes; Na+ was released in 6 s and K+ in 36 s. Accurate K+ detection by the composite electrodes was only possible above 8 mM but Na+ could be detected across the entire physiologically relevant concentration range.
|Number of pages||6|
|Publication status||Published - 14 Apr 2013|
- Alkali metal
Dube, L. E., Patel, B., Fagan-Murphy, A., Kothur, R. R., & Cragg, P. (2013). Detection of clinically important cations by a pillararene-modified electrochemical sensor. Chemical Sensors, 3(18), 1-6. http://www.cognizure.com/abstract.aspx?p=107637257