Daily Energy Expenditure through the Human Life Course

Herman Pontzer; Yosuke  Yamada; Hiroyuki Sagayama; Philip N. Ainslie; Lene F. Andersen; Liam J. Anderson; Lenore Arab; Issaad Baddou; Kweku Bedu-Addo; Ellen E. Blaak; Stephane Blanc; Alberto G. Bonomi; Carlijn V.C. Bouten; Pascal Bovet; Maciej S. Buchowski; Nancy F. Butte; Stefan G.J.A. Camps; Graeme L. Close; Jamie A. Cooper; Richard Cooper; Sai Krupa Das; Lara R. Dugas; Ulf Ekelund; Sonja Entringer; Terrence Forrester; Barry W. Fudge; Annelies H. Goris; Michael Gurven; Catherine Hambly; Asmaa El Hamdouchi; Marjije B.  Hoos; Sumei Hu; Noorjehan Joonas; Annemiek M. Joosen; Peter Katzmarzyk; Kitty P. Kempen; Misaka Kimura; William E. Kraus; Robert F. Kushner; Estelle V. Lambert; William R. Leonard; Nader Lessan; Corby K. Martin; Anine C. Medin; Erwin P. Meijer; James C. Morehen; James P.  Morton; Teresa A.  Nicklas; Robert Ojiambo; Kirsi H. Pietiläinen; Yannis Pitsiladis; Jacob  Plange-Rhule; Guy  Plasqui; Ross L.  Prentice; Roberto A.  Rabinovich; Susan B.  Racette; David A.  Raichlen; Eric  Ravussin; Rebecca M.  Reynolds; Susan B.  Roberts; Albertine J.  Schuit; Anders M.  Sjödin; Eric  Stice; Samuel S.  Urlacher; Giulio  Valenti; Ludo M.  Van Etten; Edgar A.  Van Mil; Jonathan C. K. Wells; George Wilson; Brian M.  Wood; Jack  Yanovski; Tsukasa  Yoshida; Xueying  Zhang; Alexia J.  Murphy-Alford; Cornelia  Loechl; Amy H.  Luke; Jennifer Rood; Dale A.  Schoeller; Klaas R.  Westerterp; William W. Wong; John R. Speakman

doi:10.1126/science.abe5017

Daily Energy Expenditure through the Human Life Course

Herman Pontzer, Yosuke Yamada, Hiroyuki Sagayama, Philip N. Ainslie, Lene F. Andersen, Liam J. Anderson, Lenore Arab, Issaad Baddou, Kweku Bedu-Addo, Ellen E. Blaak, Stephane Blanc, Alberto G. Bonomi, Carlijn V.C. Bouten, Pascal Bovet, Maciej S. Buchowski, Nancy F. Butte, Stefan G.J.A. Camps, Graeme L. Close, Jamie A. Cooper, Richard CooperSai Krupa Das, Lara R. Dugas, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W. Fudge, Annelies H. Goris, Michael Gurven, Catherine Hambly, Asmaa El Hamdouchi, Marjije B. Hoos, Sumei Hu, Noorjehan Joonas, Annemiek M. Joosen, Peter Katzmarzyk, Kitty P. Kempen, Misaka Kimura, William E. Kraus, Robert F. Kushner, Estelle V. Lambert, William R. Leonard, Nader Lessan, Corby K. Martin, Anine C. Medin, Erwin P. Meijer, James C. Morehen, James P. Morton, Teresa A. Nicklas, Robert Ojiambo, Kirsi H. Pietiläinen, Yannis Pitsiladis, Jacob Plange-Rhule, Guy Plasqui, Ross L. Prentice, Roberto A. Rabinovich, Susan B. Racette, David A. Raichlen, Eric Ravussin, Rebecca M. Reynolds, Susan B. Roberts, Albertine J. Schuit, Anders M. Sjödin, Eric Stice, Samuel S. Urlacher, Giulio Valenti, Ludo M. Van Etten, Edgar A. Van Mil, Jonathan C. K. Wells, George Wilson, Brian M. Wood, Jack Yanovski, Tsukasa Yoshida, Xueying Zhang, Alexia J. Murphy-Alford, Cornelia Loechl, Amy H. Luke, Jennifer Rood, Dale A. Schoeller, Klaas R. Westerterp, William W. Wong, John R. Speakman

Centre for Lifelong Health

Research output: Contribution to journal › Article › peer-review

Abstract

Total daily energy expenditure (“total expenditure”) reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass-adjusted expenditure accelerates rapidly in neonates to ~50% above adult values at ~1 year; declines slowly to adult levels by ~20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults. These changes shed light on human development and aging and should help shape nutrition and health strategies across the life span.

Original language	English
Article number	eabe5017
Pages (from-to)	808-812
Number of pages	5
Journal	Science
Volume	373
Issue number	6556
DOIs	https://doi.org/10.1126/science.abe5017
Publication status	Published - 13 Aug 2021

Bibliographical note

This is the author’s version of the work. It is posted here by permission of the AAAS for personal
use, not for redistribution. The definitive version was published in Science 373
13/08/2021, DOI: 10.1126/science.abe5017.

Funding Information: The IAEA Doubly Labeled Water (DLW) Database is generously supported by the IAEA, Taiyo Nippon Sanso, and SERCON. The authors also gratefully acknowledge funding from the US National Science Foundation (BCS-1824466) awarded to H.P. The funders played no role in the content of this manuscript.

Keywords

Multidisciplinary

Access to Document

10.1126/science.abe5017

abe5017_ArticleContent_v2Accepted author manuscript, 369 KB

Cite this

Pontzer, H., Yamada, Y., Sagayama, H., Ainslie, P. N., Andersen, L. F., Anderson, L. J., Arab, L., Baddou, I., Bedu-Addo, K., Blaak, E. E., Blanc, S., Bonomi, A. G., Bouten, C. V. C., Bovet, P., Buchowski, M. S., Butte, N. F., Camps, S. G. J. A., Close, G. L., Cooper, J. A., ... Speakman, J. R. (2021). Daily Energy Expenditure through the Human Life Course. Science, 373(6556), 808-812. Article eabe5017. https://doi.org/10.1126/science.abe5017

@article{a0d05464d3b746109a23c59b8ca42abd,

title = "Daily Energy Expenditure through the Human Life Course",

abstract = "Total daily energy expenditure (“total expenditure”) reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass-adjusted expenditure accelerates rapidly in neonates to ~50% above adult values at ~1 year; declines slowly to adult levels by ~20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults. These changes shed light on human development and aging and should help shape nutrition and health strategies across the life span.",

keywords = "Multidisciplinary",

author = "Herman Pontzer and Yosuke Yamada and Hiroyuki Sagayama and Ainslie, {Philip N.} and Andersen, {Lene F.} and Anderson, {Liam J.} and Lenore Arab and Issaad Baddou and Kweku Bedu-Addo and Blaak, {Ellen E.} and Stephane Blanc and Bonomi, {Alberto G.} and Bouten, {Carlijn V.C.} and Pascal Bovet and Buchowski, {Maciej S.} and Butte, {Nancy F.} and Camps, {Stefan G.J.A.} and Close, {Graeme L.} and Cooper, {Jamie A.} and Richard Cooper and Das, {Sai Krupa} and Dugas, {Lara R.} and Ulf Ekelund and Sonja Entringer and Terrence Forrester and Fudge, {Barry W.} and Goris, {Annelies H.} and Michael Gurven and Catherine Hambly and {El Hamdouchi}, Asmaa and Hoos, {Marjije B.} and Sumei Hu and Noorjehan Joonas and Joosen, {Annemiek M.} and Peter Katzmarzyk and Kempen, {Kitty P.} and Misaka Kimura and Kraus, {William E.} and Kushner, {Robert F.} and Lambert, {Estelle V.} and Leonard, {William R.} and Nader Lessan and Martin, {Corby K.} and Medin, {Anine C.} and Meijer, {Erwin P.} and Morehen, {James C.} and Morton, {James P.} and Nicklas, {Teresa A.} and Robert Ojiambo and Pietil{\"a}inen, {Kirsi H.} and Yannis Pitsiladis and Jacob Plange-Rhule and Guy Plasqui and Prentice, {Ross L.} and Rabinovich, {Roberto A.} and Racette, {Susan B.} and Raichlen, {David A.} and Eric Ravussin and Reynolds, {Rebecca M.} and Roberts, {Susan B.} and Schuit, {Albertine J.} and Sj{\"o}din, {Anders M.} and Eric Stice and Urlacher, {Samuel S.} and Giulio Valenti and {Van Etten}, {Ludo M.} and {Van Mil}, {Edgar A.} and Wells, {Jonathan C. K.} and George Wilson and Wood, {Brian M.} and Jack Yanovski and Tsukasa Yoshida and Xueying Zhang and Murphy-Alford, {Alexia J.} and Cornelia Loechl and Luke, {Amy H.} and Jennifer Rood and Schoeller, {Dale A.} and Westerterp, {Klaas R.} and Wong, {William W.} and Speakman, {John R.}",

note = "This is the author{\textquoteright}s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science 373 13/08/2021, DOI: 10.1126/science.abe5017. Funding Information: The IAEA Doubly Labeled Water (DLW) Database is generously supported by the IAEA, Taiyo Nippon Sanso, and SERCON. The authors also gratefully acknowledge funding from the US National Science Foundation (BCS-1824466) awarded to H.P. The funders played no role in the content of this manuscript. ",

year = "2021",

month = aug,

day = "13",

doi = "10.1126/science.abe5017",

language = "English",

volume = "373",

pages = "808--812",

journal = "Science",

issn = "1095-9203",

number = "6556",

}

Pontzer, H, Yamada, Y, Sagayama, H, Ainslie, PN, Andersen, LF, Anderson, LJ, Arab, L, Baddou, I, Bedu-Addo, K, Blaak, EE, Blanc, S, Bonomi, AG, Bouten, CVC, Bovet, P, Buchowski, MS, Butte, NF, Camps, SGJA, Close, GL, Cooper, JA, Cooper, R, Das, SK, Dugas, LR, Ekelund, U, Entringer, S, Forrester, T, Fudge, BW, Goris, AH, Gurven, M, Hambly, C, El Hamdouchi, A, Hoos, MB, Hu, S, Joonas, N, Joosen, AM, Katzmarzyk, P, Kempen, KP, Kimura, M, Kraus, WE, Kushner, RF, Lambert, EV, Leonard, WR, Lessan, N, Martin, CK, Medin, AC, Meijer, EP, Morehen, JC, Morton, JP, Nicklas, TA, Ojiambo, R, Pietiläinen, KH, Pitsiladis, Y, Plange-Rhule, J, Plasqui, G, Prentice, RL, Rabinovich, RA, Racette, SB, Raichlen, DA, Ravussin, E, Reynolds, RM, Roberts, SB, Schuit, AJ, Sjödin, AM, Stice, E, Urlacher, SS, Valenti, G, Van Etten, LM, Van Mil, EA, Wells, JCK, Wilson, G, Wood, BM, Yanovski, J, Yoshida, T, Zhang, X, Murphy-Alford, AJ, Loechl, C, Luke, AH, Rood, J, Schoeller, DA, Westerterp, KR, Wong, WW & Speakman, JR 2021, 'Daily Energy Expenditure through the Human Life Course', Science, vol. 373, no. 6556, eabe5017, pp. 808-812. https://doi.org/10.1126/science.abe5017

TY - JOUR

T1 - Daily Energy Expenditure through the Human Life Course

AU - Pontzer, Herman

AU - Yamada, Yosuke

AU - Sagayama, Hiroyuki

AU - Ainslie, Philip N.

AU - Andersen, Lene F.

AU - Anderson, Liam J.

AU - Arab, Lenore

AU - Baddou, Issaad

AU - Bedu-Addo, Kweku

AU - Blaak, Ellen E.

AU - Blanc, Stephane

AU - Bonomi, Alberto G.

AU - Bouten, Carlijn V.C.

AU - Bovet, Pascal

AU - Buchowski, Maciej S.

AU - Butte, Nancy F.

AU - Camps, Stefan G.J.A.

AU - Close, Graeme L.

AU - Cooper, Jamie A.

AU - Cooper, Richard

AU - Das, Sai Krupa

AU - Dugas, Lara R.

AU - Ekelund, Ulf

AU - Entringer, Sonja

AU - Forrester, Terrence

AU - Fudge, Barry W.

AU - Goris, Annelies H.

AU - Gurven, Michael

AU - Hambly, Catherine

AU - El Hamdouchi, Asmaa

AU - Hoos, Marjije B.

AU - Hu, Sumei

AU - Joonas, Noorjehan

AU - Joosen, Annemiek M.

AU - Katzmarzyk, Peter

AU - Kempen, Kitty P.

AU - Kimura, Misaka

AU - Kraus, William E.

AU - Kushner, Robert F.

AU - Lambert, Estelle V.

AU - Leonard, William R.

AU - Lessan, Nader

AU - Martin, Corby K.

AU - Medin, Anine C.

AU - Meijer, Erwin P.

AU - Morehen, James C.

AU - Morton, James P.

AU - Nicklas, Teresa A.

AU - Ojiambo, Robert

AU - Pietiläinen, Kirsi H.

AU - Pitsiladis, Yannis

AU - Plange-Rhule, Jacob

AU - Plasqui, Guy

AU - Prentice, Ross L.

AU - Rabinovich, Roberto A.

AU - Racette, Susan B.

AU - Raichlen, David A.

AU - Ravussin, Eric

AU - Reynolds, Rebecca M.

AU - Roberts, Susan B.

AU - Schuit, Albertine J.

AU - Sjödin, Anders M.

AU - Stice, Eric

AU - Urlacher, Samuel S.

AU - Valenti, Giulio

AU - Van Etten, Ludo M.

AU - Van Mil, Edgar A.

AU - Wells, Jonathan C. K.

AU - Wilson, George

AU - Wood, Brian M.

AU - Yanovski, Jack

AU - Yoshida, Tsukasa

AU - Zhang, Xueying

AU - Murphy-Alford, Alexia J.

AU - Loechl, Cornelia

AU - Luke, Amy H.

AU - Rood, Jennifer

AU - Schoeller, Dale A.

AU - Westerterp, Klaas R.

AU - Wong, William W.

AU - Speakman, John R.

N1 - This is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science 373 13/08/2021, DOI: 10.1126/science.abe5017. Funding Information: The IAEA Doubly Labeled Water (DLW) Database is generously supported by the IAEA, Taiyo Nippon Sanso, and SERCON. The authors also gratefully acknowledge funding from the US National Science Foundation (BCS-1824466) awarded to H.P. The funders played no role in the content of this manuscript.

PY - 2021/8/13

Y1 - 2021/8/13

N2 - Total daily energy expenditure (“total expenditure”) reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass-adjusted expenditure accelerates rapidly in neonates to ~50% above adult values at ~1 year; declines slowly to adult levels by ~20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults. These changes shed light on human development and aging and should help shape nutrition and health strategies across the life span.

AB - Total daily energy expenditure (“total expenditure”) reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass-adjusted expenditure accelerates rapidly in neonates to ~50% above adult values at ~1 year; declines slowly to adult levels by ~20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults. These changes shed light on human development and aging and should help shape nutrition and health strategies across the life span.

KW - Multidisciplinary

UR - http://www.scopus.com/inward/record.url?scp=85112515247&partnerID=8YFLogxK

U2 - 10.1126/science.abe5017

DO - 10.1126/science.abe5017

M3 - Article

SN - 1095-9203

VL - 373

SP - 808

EP - 812

JO - Science

JF - Science

IS - 6556

M1 - eabe5017

ER -

Daily Energy Expenditure through the Human Life Course

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this