Control of imaginal cell development by the escargotgene of Drosophila

Shigeo Hayashi, Susumu Hirose, Anthony Metcalfe, Alan D. Shirras

Research output: Contribution to journalArticle

Abstract

Mutations in the escargot (esg) locus, which codes for a zinc-finger-containing protein with similarity to the product of the snail gene, cause a variety of defects in adult structures such as loss of abdominal cuticle and malformation of the wings and legs. esg RNA is expressed in wing, haltere, leg and genital imaginal discs and in abdominal histoblast nests in the embryo. Expression in imaginal tissues is also found in third instar larvae. In esg mutant larvae, normally diploid abdominal histoblasts replicate their DNA without cell division and become similar in appearance to the polytene larval epidermal cells. A similar phenotype was also found in imaginal discs of larvae mutant for both esg and the Drosophila raf gene. These results suggest that one of the normal functions of esg may be the maintenance of diploidy in imaginal cells.
Original languageEnglish
Pages (from-to)105-115
Number of pages11
JournalDevelopment
Volume118
Issue number1
DOIs
Publication statusPublished - 31 May 1993

Fingerprint

imaginal discs
Drosophila
larvae
legs
diploidy
mutants
zinc finger motif
cells
genitalia
snails
cell division
embryo (animal)
genes
instars
nests
RNA
mutation
phenotype
loci
DNA

Keywords

  • Drosophila
  • histoblast
  • imaginal disc
  • ploidy
  • escargot gene

Cite this

Hayashi, S., Hirose, S., Metcalfe, A., & Shirras, A. D. (1993). Control of imaginal cell development by the escargotgene of Drosophila. Development, 118(1), 105-115. https://doi.org/10.1016/0168-9525(93)90004-2
Hayashi, Shigeo ; Hirose, Susumu ; Metcalfe, Anthony ; Shirras, Alan D. / Control of imaginal cell development by the escargotgene of Drosophila. In: Development. 1993 ; Vol. 118, No. 1. pp. 105-115.
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Hayashi, S, Hirose, S, Metcalfe, A & Shirras, AD 1993, 'Control of imaginal cell development by the escargotgene of Drosophila', Development, vol. 118, no. 1, pp. 105-115. https://doi.org/10.1016/0168-9525(93)90004-2

Control of imaginal cell development by the escargotgene of Drosophila. / Hayashi, Shigeo; Hirose, Susumu; Metcalfe, Anthony; Shirras, Alan D.

In: Development, Vol. 118, No. 1, 31.05.1993, p. 105-115.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Control of imaginal cell development by the escargotgene of Drosophila

AU - Hayashi, Shigeo

AU - Hirose, Susumu

AU - Metcalfe, Anthony

AU - Shirras, Alan D.

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AB - Mutations in the escargot (esg) locus, which codes for a zinc-finger-containing protein with similarity to the product of the snail gene, cause a variety of defects in adult structures such as loss of abdominal cuticle and malformation of the wings and legs. esg RNA is expressed in wing, haltere, leg and genital imaginal discs and in abdominal histoblast nests in the embryo. Expression in imaginal tissues is also found in third instar larvae. In esg mutant larvae, normally diploid abdominal histoblasts replicate their DNA without cell division and become similar in appearance to the polytene larval epidermal cells. A similar phenotype was also found in imaginal discs of larvae mutant for both esg and the Drosophila raf gene. These results suggest that one of the normal functions of esg may be the maintenance of diploidy in imaginal cells.

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