Continuous exercise induces airway epithelium damage while a matched-intensity and volume intermittent exercise does not

Adrien Combes; Jeanne Dekerle; Xavier Dumont; Rosie Twomey; Alfred Bernard; Frederic Daussin; Valerie Bougault

doi:10.1186/s12931-019-0978-1

Continuous exercise induces airway epithelium damage while a matched-intensity and volume intermittent exercise does not

Adrien Combes, Jeanne Dekerle, Xavier Dumont, Rosie Twomey, Alfred Bernard, Frederic Daussin, Valerie Bougault

Research output: Contribution to journal › Article › peer-review

Abstract

Background: While continuous exercise (CE) induces greater ventilation (V _E) when compared to intermittent exercise (IE), little is known of the consequences on airway damage. Our aim was to investigate markers of epithelial cell damage - i.e. serum levels of CC16 and of the CC16/SP-D ratio - during and following a bout of CE and IE of matched work. Methods: Sixteen healthy young adults performed a 30-min continuous (CE) and a 60-min intermittent exercise (IE; 1-min work: 1-min rest) on separate occasions in a random order. Intensity was set at 70% of their maximum work rate (WR _max). Heart rate (HR) and V V _E were measured throughout both tests. Blood samples were taken at rest, after the 10th min of the warm-up, at the end of both exercises, half way through IE (matched time but 50% work done for IE) as well as 30- and 60-min post-exercise. Lactate and CC16 and SP-D were determined. Results: Mean V V _E was higher for CE compared to IE (85 ± 17 l.min ^{- 1} vs 50 ± 8 l.min ^{- 1}, respectively; P < 0.001). Serum-based markers of epithelial cell damage remained unchanged during IE. Interaction of test × time was observed for SP-D (P = 0.02), CC16 (μg.l ^{- 1}) (P = 0.006) and CC16/SP-D ratio (P = 0.03). Maximum delta CC16/SP-D was significantly correlated with mean V V _E sustained (r = 0.83, P < 0.001) during CE but not during IE. Conclusion: The 30-min CE performed at 70% WR _max induced mild airway damage, while a time- or work-matched IE did not. The extent of the damage during CE was associated with the higher ventilation rate.

Original language	English
Article number	12
Journal	Respiratory Research
Volume	20
Issue number	1
DOIs	https://doi.org/10.1186/s12931-019-0978-1
Publication status	Published - 17 Jan 2019

Bibliographical note

© The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and
reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to
the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver
(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Keywords

Pneumoproteins
CC16
SP-D
Minute ventilation
Type of exercise

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Jeanne Dekerle
- J.Dekerle@brighton.ac.uk
- School of Sport and Service Management - Principal Lecturer
- Sport and Exercise Science and Sports Medicine Research and Enterprise Group
Person: Academic

Cite this

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title = "Continuous exercise induces airway epithelium damage while a matched-intensity and volume intermittent exercise does not",

abstract = "Background: While continuous exercise (CE) induces greater ventilation (V E) when compared to intermittent exercise (IE), little is known of the consequences on airway damage. Our aim was to investigate markers of epithelial cell damage - i.e. serum levels of CC16 and of the CC16/SP-D ratio - during and following a bout of CE and IE of matched work. Methods: Sixteen healthy young adults performed a 30-min continuous (CE) and a 60-min intermittent exercise (IE; 1-min work: 1-min rest) on separate occasions in a random order. Intensity was set at 70% of their maximum work rate (WR max). Heart rate (HR) and V V E were measured throughout both tests. Blood samples were taken at rest, after the 10th min of the warm-up, at the end of both exercises, half way through IE (matched time but 50% work done for IE) as well as 30- and 60-min post-exercise. Lactate and CC16 and SP-D were determined. Results: Mean V V E was higher for CE compared to IE (85 ± 17 l.min - 1 vs 50 ± 8 l.min - 1, respectively; P < 0.001). Serum-based markers of epithelial cell damage remained unchanged during IE. Interaction of test × time was observed for SP-D (P = 0.02), CC16 (μg.l - 1) (P = 0.006) and CC16/SP-D ratio (P = 0.03). Maximum delta CC16/SP-D was significantly correlated with mean V V E sustained (r = 0.83, P < 0.001) during CE but not during IE. Conclusion: The 30-min CE performed at 70% WR max induced mild airway damage, while a time- or work-matched IE did not. The extent of the damage during CE was associated with the higher ventilation rate. ",

keywords = "Pneumoproteins, CC16, SP-D, Minute ventilation, Type of exercise",

author = "Adrien Combes and Jeanne Dekerle and Xavier Dumont and Rosie Twomey and Alfred Bernard and Frederic Daussin and Valerie Bougault",

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T1 - Continuous exercise induces airway epithelium damage while a matched-intensity and volume intermittent exercise does not

AU - Combes, Adrien

AU - Dekerle, Jeanne

AU - Dumont, Xavier

AU - Twomey, Rosie

AU - Bernard, Alfred

AU - Daussin, Frederic

AU - Bougault, Valerie

N1 - © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PY - 2019/1/17

Y1 - 2019/1/17

N2 - Background: While continuous exercise (CE) induces greater ventilation (V E) when compared to intermittent exercise (IE), little is known of the consequences on airway damage. Our aim was to investigate markers of epithelial cell damage - i.e. serum levels of CC16 and of the CC16/SP-D ratio - during and following a bout of CE and IE of matched work. Methods: Sixteen healthy young adults performed a 30-min continuous (CE) and a 60-min intermittent exercise (IE; 1-min work: 1-min rest) on separate occasions in a random order. Intensity was set at 70% of their maximum work rate (WR max). Heart rate (HR) and V V E were measured throughout both tests. Blood samples were taken at rest, after the 10th min of the warm-up, at the end of both exercises, half way through IE (matched time but 50% work done for IE) as well as 30- and 60-min post-exercise. Lactate and CC16 and SP-D were determined. Results: Mean V V E was higher for CE compared to IE (85 ± 17 l.min - 1 vs 50 ± 8 l.min - 1, respectively; P < 0.001). Serum-based markers of epithelial cell damage remained unchanged during IE. Interaction of test × time was observed for SP-D (P = 0.02), CC16 (μg.l - 1) (P = 0.006) and CC16/SP-D ratio (P = 0.03). Maximum delta CC16/SP-D was significantly correlated with mean V V E sustained (r = 0.83, P < 0.001) during CE but not during IE. Conclusion: The 30-min CE performed at 70% WR max induced mild airway damage, while a time- or work-matched IE did not. The extent of the damage during CE was associated with the higher ventilation rate.

AB - Background: While continuous exercise (CE) induces greater ventilation (V E) when compared to intermittent exercise (IE), little is known of the consequences on airway damage. Our aim was to investigate markers of epithelial cell damage - i.e. serum levels of CC16 and of the CC16/SP-D ratio - during and following a bout of CE and IE of matched work. Methods: Sixteen healthy young adults performed a 30-min continuous (CE) and a 60-min intermittent exercise (IE; 1-min work: 1-min rest) on separate occasions in a random order. Intensity was set at 70% of their maximum work rate (WR max). Heart rate (HR) and V V E were measured throughout both tests. Blood samples were taken at rest, after the 10th min of the warm-up, at the end of both exercises, half way through IE (matched time but 50% work done for IE) as well as 30- and 60-min post-exercise. Lactate and CC16 and SP-D were determined. Results: Mean V V E was higher for CE compared to IE (85 ± 17 l.min - 1 vs 50 ± 8 l.min - 1, respectively; P < 0.001). Serum-based markers of epithelial cell damage remained unchanged during IE. Interaction of test × time was observed for SP-D (P = 0.02), CC16 (μg.l - 1) (P = 0.006) and CC16/SP-D ratio (P = 0.03). Maximum delta CC16/SP-D was significantly correlated with mean V V E sustained (r = 0.83, P < 0.001) during CE but not during IE. Conclusion: The 30-min CE performed at 70% WR max induced mild airway damage, while a time- or work-matched IE did not. The extent of the damage during CE was associated with the higher ventilation rate.

KW - Pneumoproteins

KW - CC16

KW - SP-D

KW - Minute ventilation

KW - Type of exercise

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