Continuous exercise induces airway epithelium damage while a matched-intensity and volume intermittent exercise does not

Adrien Combes, Jeanne Dekerle, Xavier Dumont, Rosie Twomey, Alfred Bernard, Frederic Daussin, Valerie Bougault

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background: While continuous exercise (CE) induces greater ventilation (V E) when compared to intermittent exercise (IE), little is known of the consequences on airway damage. Our aim was to investigate markers of epithelial cell damage - i.e. serum levels of CC16 and of the CC16/SP-D ratio - during and following a bout of CE and IE of matched work. Methods: Sixteen healthy young adults performed a 30-min continuous (CE) and a 60-min intermittent exercise (IE; 1-min work: 1-min rest) on separate occasions in a random order. Intensity was set at 70% of their maximum work rate (WR max). Heart rate (HR) and V V E were measured throughout both tests. Blood samples were taken at rest, after the 10th min of the warm-up, at the end of both exercises, half way through IE (matched time but 50% work done for IE) as well as 30- and 60-min post-exercise. Lactate and CC16 and SP-D were determined. Results: Mean V V E was higher for CE compared to IE (85 ± 17 l.min - 1 vs 50 ± 8 l.min - 1, respectively; P < 0.001). Serum-based markers of epithelial cell damage remained unchanged during IE. Interaction of test × time was observed for SP-D (P = 0.02), CC16 (μg.l - 1) (P = 0.006) and CC16/SP-D ratio (P = 0.03). Maximum delta CC16/SP-D was significantly correlated with mean V V E sustained (r = 0.83, P < 0.001) during CE but not during IE. Conclusion: The 30-min CE performed at 70% WR max induced mild airway damage, while a time- or work-matched IE did not. The extent of the damage during CE was associated with the higher ventilation rate.

Original languageEnglish
Article number12
JournalRespiratory Research
Volume20
Issue number1
DOIs
Publication statusPublished - 17 Jan 2019

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Epithelium
Exercise
Pulmonary Surfactant-Associated Protein D
Ventilation
Epithelial Cells
Young Adult
Lactic Acid
Biomarkers
Heart Rate

Bibliographical note

© The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and
reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to
the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver
(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Keywords

  • Pneumoproteins
  • CC16
  • SP-D
  • Minute ventilation
  • Type of exercise

Cite this

Combes, Adrien ; Dekerle, Jeanne ; Dumont, Xavier ; Twomey, Rosie ; Bernard, Alfred ; Daussin, Frederic ; Bougault, Valerie. / Continuous exercise induces airway epithelium damage while a matched-intensity and volume intermittent exercise does not. 2019 ; Vol. 20, No. 1.
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abstract = "Background: While continuous exercise (CE) induces greater ventilation (V E) when compared to intermittent exercise (IE), little is known of the consequences on airway damage. Our aim was to investigate markers of epithelial cell damage - i.e. serum levels of CC16 and of the CC16/SP-D ratio - during and following a bout of CE and IE of matched work. Methods: Sixteen healthy young adults performed a 30-min continuous (CE) and a 60-min intermittent exercise (IE; 1-min work: 1-min rest) on separate occasions in a random order. Intensity was set at 70{\%} of their maximum work rate (WR max). Heart rate (HR) and V V E were measured throughout both tests. Blood samples were taken at rest, after the 10th min of the warm-up, at the end of both exercises, half way through IE (matched time but 50{\%} work done for IE) as well as 30- and 60-min post-exercise. Lactate and CC16 and SP-D were determined. Results: Mean V V E was higher for CE compared to IE (85 ± 17 l.min - 1 vs 50 ± 8 l.min - 1, respectively; P < 0.001). Serum-based markers of epithelial cell damage remained unchanged during IE. Interaction of test × time was observed for SP-D (P = 0.02), CC16 (μg.l - 1) (P = 0.006) and CC16/SP-D ratio (P = 0.03). Maximum delta CC16/SP-D was significantly correlated with mean V V E sustained (r = 0.83, P < 0.001) during CE but not during IE. Conclusion: The 30-min CE performed at 70{\%} WR max induced mild airway damage, while a time- or work-matched IE did not. The extent of the damage during CE was associated with the higher ventilation rate.",
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Continuous exercise induces airway epithelium damage while a matched-intensity and volume intermittent exercise does not. / Combes, Adrien; Dekerle, Jeanne; Dumont, Xavier; Twomey, Rosie; Bernard, Alfred; Daussin, Frederic; Bougault, Valerie.

Vol. 20, No. 1, 12, 17.01.2019.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Continuous exercise induces airway epithelium damage while a matched-intensity and volume intermittent exercise does not

AU - Combes, Adrien

AU - Dekerle, Jeanne

AU - Dumont, Xavier

AU - Twomey, Rosie

AU - Bernard, Alfred

AU - Daussin, Frederic

AU - Bougault, Valerie

N1 - © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Y1 - 2019/1/17

N2 - Background: While continuous exercise (CE) induces greater ventilation (V E) when compared to intermittent exercise (IE), little is known of the consequences on airway damage. Our aim was to investigate markers of epithelial cell damage - i.e. serum levels of CC16 and of the CC16/SP-D ratio - during and following a bout of CE and IE of matched work. Methods: Sixteen healthy young adults performed a 30-min continuous (CE) and a 60-min intermittent exercise (IE; 1-min work: 1-min rest) on separate occasions in a random order. Intensity was set at 70% of their maximum work rate (WR max). Heart rate (HR) and V V E were measured throughout both tests. Blood samples were taken at rest, after the 10th min of the warm-up, at the end of both exercises, half way through IE (matched time but 50% work done for IE) as well as 30- and 60-min post-exercise. Lactate and CC16 and SP-D were determined. Results: Mean V V E was higher for CE compared to IE (85 ± 17 l.min - 1 vs 50 ± 8 l.min - 1, respectively; P < 0.001). Serum-based markers of epithelial cell damage remained unchanged during IE. Interaction of test × time was observed for SP-D (P = 0.02), CC16 (μg.l - 1) (P = 0.006) and CC16/SP-D ratio (P = 0.03). Maximum delta CC16/SP-D was significantly correlated with mean V V E sustained (r = 0.83, P < 0.001) during CE but not during IE. Conclusion: The 30-min CE performed at 70% WR max induced mild airway damage, while a time- or work-matched IE did not. The extent of the damage during CE was associated with the higher ventilation rate.

AB - Background: While continuous exercise (CE) induces greater ventilation (V E) when compared to intermittent exercise (IE), little is known of the consequences on airway damage. Our aim was to investigate markers of epithelial cell damage - i.e. serum levels of CC16 and of the CC16/SP-D ratio - during and following a bout of CE and IE of matched work. Methods: Sixteen healthy young adults performed a 30-min continuous (CE) and a 60-min intermittent exercise (IE; 1-min work: 1-min rest) on separate occasions in a random order. Intensity was set at 70% of their maximum work rate (WR max). Heart rate (HR) and V V E were measured throughout both tests. Blood samples were taken at rest, after the 10th min of the warm-up, at the end of both exercises, half way through IE (matched time but 50% work done for IE) as well as 30- and 60-min post-exercise. Lactate and CC16 and SP-D were determined. Results: Mean V V E was higher for CE compared to IE (85 ± 17 l.min - 1 vs 50 ± 8 l.min - 1, respectively; P < 0.001). Serum-based markers of epithelial cell damage remained unchanged during IE. Interaction of test × time was observed for SP-D (P = 0.02), CC16 (μg.l - 1) (P = 0.006) and CC16/SP-D ratio (P = 0.03). Maximum delta CC16/SP-D was significantly correlated with mean V V E sustained (r = 0.83, P < 0.001) during CE but not during IE. Conclusion: The 30-min CE performed at 70% WR max induced mild airway damage, while a time- or work-matched IE did not. The extent of the damage during CE was associated with the higher ventilation rate.

KW - Pneumoproteins

KW - CC16

KW - SP-D

KW - Minute ventilation

KW - Type of exercise

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