Abstract
Background: While continuous exercise (CE) induces greater ventilation (V E) when compared to intermittent exercise (IE), little is known of the consequences on airway damage. Our aim was to investigate markers of epithelial cell damage - i.e. serum levels of CC16 and of the CC16/SP-D ratio - during and following a bout of CE and IE of matched work. Methods: Sixteen healthy young adults performed a 30-min continuous (CE) and a 60-min intermittent exercise (IE; 1-min work: 1-min rest) on separate occasions in a random order. Intensity was set at 70% of their maximum work rate (WR max). Heart rate (HR) and V V E were measured throughout both tests. Blood samples were taken at rest, after the 10th min of the warm-up, at the end of both exercises, half way through IE (matched time but 50% work done for IE) as well as 30- and 60-min post-exercise. Lactate and CC16 and SP-D were determined. Results: Mean V V E was higher for CE compared to IE (85 ± 17 l.min - 1 vs 50 ± 8 l.min - 1, respectively; P < 0.001). Serum-based markers of epithelial cell damage remained unchanged during IE. Interaction of test × time was observed for SP-D (P = 0.02), CC16 (μg.l - 1) (P = 0.006) and CC16/SP-D ratio (P = 0.03). Maximum delta CC16/SP-D was significantly correlated with mean V V E sustained (r = 0.83, P < 0.001) during CE but not during IE. Conclusion: The 30-min CE performed at 70% WR max induced mild airway damage, while a time- or work-matched IE did not. The extent of the damage during CE was associated with the higher ventilation rate.
| Original language | English |
|---|---|
| Article number | 12 |
| Journal | Respiratory Research |
| Volume | 20 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 17 Jan 2019 |
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Bibliographical note
© The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and
reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to
the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver
(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Keywords
- Pneumoproteins
- CC16
- SP-D
- Minute ventilation
- Type of exercise
Cite this
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Continuous exercise induces airway epithelium damage while a matched-intensity and volume intermittent exercise does not. / Combes, Adrien; Dekerle, Jeanne; Dumont, Xavier; Twomey, Rosie; Bernard, Alfred; Daussin, Frederic; Bougault, Valerie.
In: Respiratory Research, Vol. 20, No. 1, 12, 17.01.2019.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Continuous exercise induces airway epithelium damage while a matched-intensity and volume intermittent exercise does not
AU - Combes, Adrien
AU - Dekerle, Jeanne
AU - Dumont, Xavier
AU - Twomey, Rosie
AU - Bernard, Alfred
AU - Daussin, Frederic
AU - Bougault, Valerie
N1 - © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
PY - 2019/1/17
Y1 - 2019/1/17
N2 - Background: While continuous exercise (CE) induces greater ventilation (V E) when compared to intermittent exercise (IE), little is known of the consequences on airway damage. Our aim was to investigate markers of epithelial cell damage - i.e. serum levels of CC16 and of the CC16/SP-D ratio - during and following a bout of CE and IE of matched work. Methods: Sixteen healthy young adults performed a 30-min continuous (CE) and a 60-min intermittent exercise (IE; 1-min work: 1-min rest) on separate occasions in a random order. Intensity was set at 70% of their maximum work rate (WR max). Heart rate (HR) and V V E were measured throughout both tests. Blood samples were taken at rest, after the 10th min of the warm-up, at the end of both exercises, half way through IE (matched time but 50% work done for IE) as well as 30- and 60-min post-exercise. Lactate and CC16 and SP-D were determined. Results: Mean V V E was higher for CE compared to IE (85 ± 17 l.min - 1 vs 50 ± 8 l.min - 1, respectively; P < 0.001). Serum-based markers of epithelial cell damage remained unchanged during IE. Interaction of test × time was observed for SP-D (P = 0.02), CC16 (μg.l - 1) (P = 0.006) and CC16/SP-D ratio (P = 0.03). Maximum delta CC16/SP-D was significantly correlated with mean V V E sustained (r = 0.83, P < 0.001) during CE but not during IE. Conclusion: The 30-min CE performed at 70% WR max induced mild airway damage, while a time- or work-matched IE did not. The extent of the damage during CE was associated with the higher ventilation rate.
AB - Background: While continuous exercise (CE) induces greater ventilation (V E) when compared to intermittent exercise (IE), little is known of the consequences on airway damage. Our aim was to investigate markers of epithelial cell damage - i.e. serum levels of CC16 and of the CC16/SP-D ratio - during and following a bout of CE and IE of matched work. Methods: Sixteen healthy young adults performed a 30-min continuous (CE) and a 60-min intermittent exercise (IE; 1-min work: 1-min rest) on separate occasions in a random order. Intensity was set at 70% of their maximum work rate (WR max). Heart rate (HR) and V V E were measured throughout both tests. Blood samples were taken at rest, after the 10th min of the warm-up, at the end of both exercises, half way through IE (matched time but 50% work done for IE) as well as 30- and 60-min post-exercise. Lactate and CC16 and SP-D were determined. Results: Mean V V E was higher for CE compared to IE (85 ± 17 l.min - 1 vs 50 ± 8 l.min - 1, respectively; P < 0.001). Serum-based markers of epithelial cell damage remained unchanged during IE. Interaction of test × time was observed for SP-D (P = 0.02), CC16 (μg.l - 1) (P = 0.006) and CC16/SP-D ratio (P = 0.03). Maximum delta CC16/SP-D was significantly correlated with mean V V E sustained (r = 0.83, P < 0.001) during CE but not during IE. Conclusion: The 30-min CE performed at 70% WR max induced mild airway damage, while a time- or work-matched IE did not. The extent of the damage during CE was associated with the higher ventilation rate.
KW - Pneumoproteins
KW - CC16
KW - SP-D
KW - Minute ventilation
KW - Type of exercise
UR - http://www.scopus.com/inward/record.url?scp=85060157084&partnerID=8YFLogxK
U2 - 10.1186/s12931-019-0978-1
DO - 10.1186/s12931-019-0978-1
M3 - Article
VL - 20
JO - Respiratory Research
T2 - Respiratory Research
JF - Respiratory Research
SN - 1465-9921
IS - 1
M1 - 12
ER -