Conservation of cancer genes in the marine invertebrate Mytilus edulis

Corina Ciocan, Jeanette Rotchell

    Research output: Contribution to journalArticlepeer-review


    Mussels are susceptible to a wide range of environmental
    toxicants, including carcinogens, and thus are often
    employed as bioindicator species. To elucidate the molecular
    aetiology of such neoplastic damage, we have cloned
    Mytilus edulis homologues of the vertebrate ras protooncogene,
    and p53 tumor suppressor gene. The M. edulis
    ras cDNA encodes a predicted protein of 184 amino
    acids. The DNA sequence analysis with vertebrate ras
    sequences demonstrates that the M. edulis ras cDNA is
    highly conserved in regions of functional importance, including
    mutational hot spots. The partial p53 sequence also
    demonstrates that M. edulis p53 is highly conserved in
    two regions of functional importance and that these regions
    also include four of the five mutational hot spots for this
    gene. In contrast, the M. edulis p53 sequence shows little
    similarity to the other published invertebrate p53-like
    sequences. The cancer gene sequences characterized
    herein will allow development of specific biomarkers of
    genotoxic damage.
    Original languageEnglish
    Pages (from-to)3029-3033
    Number of pages3033
    JournalEnvironmental Science and Technology
    Issue number9
    Publication statusPublished - 11 Mar 2005


    • cancer genes
    • molecular biology
    • marine invertebrates


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