COL5A1 gene variants previously associated with reduced soft tissue injury risk are associated with elite athlete status in rugby

Shane M. Heffernan, Liam P. Kilduff, R.M. Erskine, Stephen H. Day, G.K. Stebbings, C.J. Cook, S.M. Raleigh, M.A. Bennett, Guan Wang, Malcolm Collins, Yannis Pitsiladis, A.G. Williams

Research output: Contribution to journalArticle

Abstract

Two common single nucleotide polymorphisms within the COL5A1 gene (SNPs; rs12722 C/T and rs3196378 C/A) have previously been associated with tendon and ligament pathologies. Given the high incidence of tendon and ligament injuries in elite rugby athletes, we hypothesised that both SNPs would be associated with career success.
Original languageEnglish
JournalBMC Genomics
Volume18
Issue numberS8
DOIs
Publication statusPublished - 14 Nov 2017

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Soft Tissue Injuries
Football
Athletes
Single Nucleotide Polymorphism
Ligaments
Genes
Tendon Injuries
Tendons
Pathology
Incidence

Bibliographical note

© The Author(s). 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Cite this

Heffernan, S. M., Kilduff, L. P., Erskine, R. M., Day, S. H., Stebbings, G. K., Cook, C. J., ... Williams, A. G. (2017). COL5A1 gene variants previously associated with reduced soft tissue injury risk are associated with elite athlete status in rugby. BMC Genomics, 18(S8). https://doi.org/10.1186/s12864-017-4187-3
Heffernan, Shane M. ; Kilduff, Liam P. ; Erskine, R.M. ; Day, Stephen H. ; Stebbings, G.K. ; Cook, C.J. ; Raleigh, S.M. ; Bennett, M.A. ; Wang, Guan ; Collins, Malcolm ; Pitsiladis, Yannis ; Williams, A.G. / COL5A1 gene variants previously associated with reduced soft tissue injury risk are associated with elite athlete status in rugby. In: BMC Genomics. 2017 ; Vol. 18, No. S8.
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abstract = "Two common single nucleotide polymorphisms within the COL5A1 gene (SNPs; rs12722 C/T and rs3196378 C/A) have previously been associated with tendon and ligament pathologies. Given the high incidence of tendon and ligament injuries in elite rugby athletes, we hypothesised that both SNPs would be associated with career success.",
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Heffernan, SM, Kilduff, LP, Erskine, RM, Day, SH, Stebbings, GK, Cook, CJ, Raleigh, SM, Bennett, MA, Wang, G, Collins, M, Pitsiladis, Y & Williams, AG 2017, 'COL5A1 gene variants previously associated with reduced soft tissue injury risk are associated with elite athlete status in rugby', BMC Genomics, vol. 18, no. S8. https://doi.org/10.1186/s12864-017-4187-3

COL5A1 gene variants previously associated with reduced soft tissue injury risk are associated with elite athlete status in rugby. / Heffernan, Shane M.; Kilduff, Liam P.; Erskine, R.M.; Day, Stephen H.; Stebbings, G.K.; Cook, C.J.; Raleigh, S.M.; Bennett, M.A.; Wang, Guan; Collins, Malcolm; Pitsiladis, Yannis; Williams, A.G.

In: BMC Genomics, Vol. 18, No. S8, 14.11.2017.

Research output: Contribution to journalArticle

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AU - Heffernan, Shane M.

AU - Kilduff, Liam P.

AU - Erskine, R.M.

AU - Day, Stephen H.

AU - Stebbings, G.K.

AU - Cook, C.J.

AU - Raleigh, S.M.

AU - Bennett, M.A.

AU - Wang, Guan

AU - Collins, Malcolm

AU - Pitsiladis, Yannis

AU - Williams, A.G.

N1 - © The Author(s). 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PY - 2017/11/14

Y1 - 2017/11/14

N2 - Two common single nucleotide polymorphisms within the COL5A1 gene (SNPs; rs12722 C/T and rs3196378 C/A) have previously been associated with tendon and ligament pathologies. Given the high incidence of tendon and ligament injuries in elite rugby athletes, we hypothesised that both SNPs would be associated with career success.

AB - Two common single nucleotide polymorphisms within the COL5A1 gene (SNPs; rs12722 C/T and rs3196378 C/A) have previously been associated with tendon and ligament pathologies. Given the high incidence of tendon and ligament injuries in elite rugby athletes, we hypothesised that both SNPs would be associated with career success.

U2 - 10.1186/s12864-017-4187-3

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M3 - Article

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JO - BMC Genomics

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