Chemical analysis of aging: testing predictions from green theory

Elizabeth Ostler; A. Iqbal; Richard Faragher; D. Naughton; M. Piper; L. Partridge

Abstract

Methods: Environmental and genetic interventions were applied to examine their effects on age-related changes in the chemical composition of Drosophila melanogaster. Novel analytical methods were developed and validated to investigate the accumulation, with age, of stable molecular damage in flies. Results: Cohorts of Drosophila with extended lifespans showed a reduced rate of accumulation of signals consistent with damage during ageing compared to wild-type cohorts cultured under normal conditions. Spectrometric analysis also revealed distinct age-associated qualitative changes. Main conclusion: This work represents the first use of a range of analytical techniques to characterise and quantify compounds associated with, and possibly causing, different rates of ageing in Drosophila melanogaster.

Original language	English
Pages	64
Publication status	Published - 2011
Event	40th American Aging Association Annual Meeting 2011 - Raleigh, North Carolina, 3-6 June, 2011 Duration: 1 Jan 2011 → …

Conference

Conference	40th American Aging Association Annual Meeting 2011
Period	1/01/11 → …

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title = "Chemical analysis of aging: testing predictions from green theory",

abstract = "Methods: Environmental and genetic interventions were applied to examine their effects on age-related changes in the chemical composition of Drosophila melanogaster. Novel analytical methods were developed and validated to investigate the accumulation, with age, of stable molecular damage in flies. Results: Cohorts of Drosophila with extended lifespans showed a reduced rate of accumulation of signals consistent with damage during ageing compared to wild-type cohorts cultured under normal conditions. Spectrometric analysis also revealed distinct age-associated qualitative changes. Main conclusion: This work represents the first use of a range of analytical techniques to characterise and quantify compounds associated with, and possibly causing, different rates of ageing in Drosophila melanogaster.",

author = "Elizabeth Ostler and A. Iqbal and Richard Faragher and D. Naughton and M. Piper and L. Partridge",

year = "2011",

language = "English",

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T1 - Chemical analysis of aging: testing predictions from green theory

AU - Ostler, Elizabeth

AU - Iqbal, A.

AU - Faragher, Richard

AU - Naughton, D.

AU - Piper, M.

AU - Partridge, L.

PY - 2011

Y1 - 2011

N2 - Methods: Environmental and genetic interventions were applied to examine their effects on age-related changes in the chemical composition of Drosophila melanogaster. Novel analytical methods were developed and validated to investigate the accumulation, with age, of stable molecular damage in flies. Results: Cohorts of Drosophila with extended lifespans showed a reduced rate of accumulation of signals consistent with damage during ageing compared to wild-type cohorts cultured under normal conditions. Spectrometric analysis also revealed distinct age-associated qualitative changes. Main conclusion: This work represents the first use of a range of analytical techniques to characterise and quantify compounds associated with, and possibly causing, different rates of ageing in Drosophila melanogaster.

AB - Methods: Environmental and genetic interventions were applied to examine their effects on age-related changes in the chemical composition of Drosophila melanogaster. Novel analytical methods were developed and validated to investigate the accumulation, with age, of stable molecular damage in flies. Results: Cohorts of Drosophila with extended lifespans showed a reduced rate of accumulation of signals consistent with damage during ageing compared to wild-type cohorts cultured under normal conditions. Spectrometric analysis also revealed distinct age-associated qualitative changes. Main conclusion: This work represents the first use of a range of analytical techniques to characterise and quantify compounds associated with, and possibly causing, different rates of ageing in Drosophila melanogaster.

M3 - Abstract

SP - 64

T2 - 40th American Aging Association Annual Meeting 2011

Y2 - 1 January 2011

ER -

Chemical analysis of aging: testing predictions from green theory

Abstract

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