Abstract
Methods: Environmental and genetic interventions were applied to examine their effects on age-related changes in the chemical composition of Drosophila melanogaster. Novel analytical methods were developed and validated to investigate the accumulation, with age, of stable molecular damage in flies.
Results: Cohorts of Drosophila with extended lifespans showed a reduced rate of accumulation of signals consistent with damage during ageing compared to wild-type cohorts cultured under normal conditions. Spectrometric analysis also revealed distinct age-associated qualitative changes.
Main conclusion: This work represents the first use of a range of analytical techniques to characterise and quantify compounds associated with, and possibly causing, different rates of ageing in Drosophila melanogaster.
Original language | English |
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Pages | 64 |
Publication status | Published - 2011 |
Event | 40th American Aging Association Annual Meeting 2011 - Raleigh, North Carolina, 3-6 June, 2011 Duration: 1 Jan 2011 → … |
Conference
Conference | 40th American Aging Association Annual Meeting 2011 |
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Period | 1/01/11 → … |