Chemical analysis of aging: testing predictions from green theory

Elizabeth Ostler, A. Iqbal, Richard Faragher, D. Naughton, M. Piper, L. Partridge

Research output: Contribution to conferenceAbstract

Abstract

Methods: Environmental and genetic interventions were applied to examine their effects on age-related changes in the chemical composition of Drosophila melanogaster. Novel analytical methods were developed and validated to investigate the accumulation, with age, of stable molecular damage in flies. Results: Cohorts of Drosophila with extended lifespans showed a reduced rate of accumulation of signals consistent with damage during ageing compared to wild-type cohorts cultured under normal conditions. Spectrometric analysis also revealed distinct age-associated qualitative changes. Main conclusion: This work represents the first use of a range of analytical techniques to characterise and quantify compounds associated with, and possibly causing, different rates of ageing in Drosophila melanogaster.
Original languageEnglish
Pages64
Publication statusPublished - 2011
Event40th American Aging Association Annual Meeting 2011 - Raleigh, North Carolina, 3-6 June, 2011
Duration: 1 Jan 2011 → …

Conference

Conference40th American Aging Association Annual Meeting 2011
Period1/01/11 → …

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Drosophila melanogaster
Genetic Engineering
Diptera
Drosophila

Cite this

Ostler, E., Iqbal, A., Faragher, R., Naughton, D., Piper, M., & Partridge, L. (2011). Chemical analysis of aging: testing predictions from green theory. 64. Abstract from 40th American Aging Association Annual Meeting 2011, .
Ostler, Elizabeth ; Iqbal, A. ; Faragher, Richard ; Naughton, D. ; Piper, M. ; Partridge, L. / Chemical analysis of aging: testing predictions from green theory. Abstract from 40th American Aging Association Annual Meeting 2011, .
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Ostler, E, Iqbal, A, Faragher, R, Naughton, D, Piper, M & Partridge, L 2011, 'Chemical analysis of aging: testing predictions from green theory' 40th American Aging Association Annual Meeting 2011, 1/01/11, pp. 64.

Chemical analysis of aging: testing predictions from green theory. / Ostler, Elizabeth; Iqbal, A.; Faragher, Richard; Naughton, D.; Piper, M.; Partridge, L.

2011. 64 Abstract from 40th American Aging Association Annual Meeting 2011, .

Research output: Contribution to conferenceAbstract

TY - CONF

T1 - Chemical analysis of aging: testing predictions from green theory

AU - Ostler, Elizabeth

AU - Iqbal, A.

AU - Faragher, Richard

AU - Naughton, D.

AU - Piper, M.

AU - Partridge, L.

PY - 2011

Y1 - 2011

N2 - Methods: Environmental and genetic interventions were applied to examine their effects on age-related changes in the chemical composition of Drosophila melanogaster. Novel analytical methods were developed and validated to investigate the accumulation, with age, of stable molecular damage in flies. Results: Cohorts of Drosophila with extended lifespans showed a reduced rate of accumulation of signals consistent with damage during ageing compared to wild-type cohorts cultured under normal conditions. Spectrometric analysis also revealed distinct age-associated qualitative changes. Main conclusion: This work represents the first use of a range of analytical techniques to characterise and quantify compounds associated with, and possibly causing, different rates of ageing in Drosophila melanogaster.

AB - Methods: Environmental and genetic interventions were applied to examine their effects on age-related changes in the chemical composition of Drosophila melanogaster. Novel analytical methods were developed and validated to investigate the accumulation, with age, of stable molecular damage in flies. Results: Cohorts of Drosophila with extended lifespans showed a reduced rate of accumulation of signals consistent with damage during ageing compared to wild-type cohorts cultured under normal conditions. Spectrometric analysis also revealed distinct age-associated qualitative changes. Main conclusion: This work represents the first use of a range of analytical techniques to characterise and quantify compounds associated with, and possibly causing, different rates of ageing in Drosophila melanogaster.

M3 - Abstract

SP - 64

ER -

Ostler E, Iqbal A, Faragher R, Naughton D, Piper M, Partridge L. Chemical analysis of aging: testing predictions from green theory. 2011. Abstract from 40th American Aging Association Annual Meeting 2011, .