Characterization of a Standard Strain of Human Scleral Fibroblasts

Research output: Contribution to conferenceAbstract

Abstract

Abnormal wound healing and ocular scarring play a role in either the pathogenesis or treatment failure of most blinding diseases, including post-operative failure of glaucoma filtration surgery. Although use of human cells derived from primary tissue is optimal for studying these processes, such cells exhibit a reduced division capacity leading to senescence in vitro, which limits opportunities for research. In human dermal fibroblasts it has been shown that this "replicative senescence" is triggered by progressive telomeric attrition and can be prevented by ectopic expression of the catalytic subunit of human telomere reverse transcriptase (telomerase or hTERT). Telomerase expression results in immortal cell lines with a phenotype similar to that of normal primary cells. The goal of this project is the derivation of an immortalized ocular fibroblast cell line, which would facilitate the study of therapeutic targets in ocular disease.
Original languageEnglish
Pages0-0
Number of pages1
Publication statusPublished - 1 May 2003
EventAnnual Meeting of the Association for Research in Vision and Opthalmology 2003 - Fort Lauderdale, FL, USA, 2003
Duration: 1 May 2003 → …

Conference

ConferenceAnnual Meeting of the Association for Research in Vision and Opthalmology 2003
Period1/05/03 → …

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    Sheerin, A. (2003). Characterization of a Standard Strain of Human Scleral Fibroblasts. 0-0. Abstract from Annual Meeting of the Association for Research in Vision and Opthalmology 2003, .