Cell-mediated immunity to human CMV infection: a brief overview

Nadia Terrazzini, Florian Kern

Research output: Contribution to journalArticle

Abstract

The cellular immune response to human cytomegalovirus (HCMV) has different components originating from both the adaptive and innate immune systems. There is a significant global interest in understanding how the immune system keeps HCMV under control, in particular with a view to situations where HCMV infection causes severe damage. Such settings include HIV infection, transplantation, and maybe most importantly perinatal medicine, HCMV being a major cause of sometimes catastrophic birth defects. The development of an active HCMV vaccine has proven very difficult but some recent successes raise hope that this might be available in the future. However, adoptive transfer of HCMV-specific T cells has been successfully used to prevent CMV disease after bone marrow transplantation for many years. In fact, the CD8 T cell response has been thought to be the most important effector response, with numerous reports focusing on specific T cell subsets recognizing select peptides in select human leukocyte antigen (HLA) contexts. However, it is becoming increasingly clear now that other cells, first and foremost CD4 T cells, but also gamma/delta (γ/δ) T cells and natural killer cells, are critically involved in the cellular immune response to HCMV. This commentary aims to provide a brief overview of the field.
Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalF1000Prime Reports
Volume6
Issue number28
DOIs
Publication statusPublished - 6 May 2014

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Cellular Immunity
Cytomegalovirus
Infection
T-Lymphocytes
Immune System
Cytomegalovirus Vaccines
Hope
Somatostatin-Secreting Cells
Adoptive Transfer
Cytomegalovirus Infections
Human Development
T-Lymphocyte Subsets
HLA Antigens
Bone Marrow Transplantation
Natural Killer Cells
HIV Infections
Transplantation
Medicine
Peptides

Bibliographical note

All F1000Prime Reports articles are distributed under the terms of the Creative Commons Attribution-Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/legalcode), which permits non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Cite this

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abstract = "The cellular immune response to human cytomegalovirus (HCMV) has different components originating from both the adaptive and innate immune systems. There is a significant global interest in understanding how the immune system keeps HCMV under control, in particular with a view to situations where HCMV infection causes severe damage. Such settings include HIV infection, transplantation, and maybe most importantly perinatal medicine, HCMV being a major cause of sometimes catastrophic birth defects. The development of an active HCMV vaccine has proven very difficult but some recent successes raise hope that this might be available in the future. However, adoptive transfer of HCMV-specific T cells has been successfully used to prevent CMV disease after bone marrow transplantation for many years. In fact, the CD8 T cell response has been thought to be the most important effector response, with numerous reports focusing on specific T cell subsets recognizing select peptides in select human leukocyte antigen (HLA) contexts. However, it is becoming increasingly clear now that other cells, first and foremost CD4 T cells, but also gamma/delta (γ/δ) T cells and natural killer cells, are critically involved in the cellular immune response to HCMV. This commentary aims to provide a brief overview of the field.",
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Cell-mediated immunity to human CMV infection: a brief overview. / Terrazzini, Nadia; Kern, Florian.

In: F1000Prime Reports, Vol. 6, No. 28, 06.05.2014, p. 1-9.

Research output: Contribution to journalArticle

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