Can we say that senescent cells cause ageing?

Research output: Contribution to journalArticle

Abstract

Replicative senescence, the irreversible loss of proliferative capacity, is a common feature of somatic cells derived from many different species. The molecular mechanisms controlling senescence in mammals, and especially in humans, have now been substantively elucidated. However, to date, attempts to link the senescence of cells with the ageing of the organisms they comprise has not met with any similar degree of success, largely due to a lack of systematic investigation and the absence of the necessary biochemical tools. This review will summarise current data linking replicative senescence and organismal ageing. It will also suggest some essential tests of the cell senescence hypothesis and some necessary ground work which must be carried out before such tests can be fruitfully performed. It will not discuss the detailed molecular ‘clockwork’ controlling the decision to exit the cell cycle irreversibly because this is covered by other authors in this special issue.
Original languageEnglish
Pages (from-to)1319-1326
Number of pages8
JournalExperimental Gerontology
Volume38
Issue number11-12
DOIs
Publication statusPublished - Nov 2003

Fingerprint

somatic cells
cell cycle
testing
cells
mammals
organisms
cell senescence

Keywords

  • Senescence
  • Marker
  • Werner's syndrome
  • Telomerase

Cite this

@article{e7ad92aab9e244158a33ad92e57c8416,
title = "Can we say that senescent cells cause ageing?",
abstract = "Replicative senescence, the irreversible loss of proliferative capacity, is a common feature of somatic cells derived from many different species. The molecular mechanisms controlling senescence in mammals, and especially in humans, have now been substantively elucidated. However, to date, attempts to link the senescence of cells with the ageing of the organisms they comprise has not met with any similar degree of success, largely due to a lack of systematic investigation and the absence of the necessary biochemical tools. This review will summarise current data linking replicative senescence and organismal ageing. It will also suggest some essential tests of the cell senescence hypothesis and some necessary ground work which must be carried out before such tests can be fruitfully performed. It will not discuss the detailed molecular ‘clockwork’ controlling the decision to exit the cell cycle irreversibly because this is covered by other authors in this special issue.",
keywords = "Senescence, Marker, Werner's syndrome, Telomerase",
author = "J. Bird and Elizabeth Ostler and Richard Faragher",
year = "2003",
month = "11",
doi = "10.1016/j.exger.2003.09.011",
language = "English",
volume = "38",
pages = "1319--1326",
journal = "Experimental Gerontology",
issn = "0531-5565",
number = "11-12",

}

Can we say that senescent cells cause ageing? / Bird, J.; Ostler, Elizabeth; Faragher, Richard.

In: Experimental Gerontology, Vol. 38, No. 11-12, 11.2003, p. 1319-1326.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Can we say that senescent cells cause ageing?

AU - Bird, J.

AU - Ostler, Elizabeth

AU - Faragher, Richard

PY - 2003/11

Y1 - 2003/11

N2 - Replicative senescence, the irreversible loss of proliferative capacity, is a common feature of somatic cells derived from many different species. The molecular mechanisms controlling senescence in mammals, and especially in humans, have now been substantively elucidated. However, to date, attempts to link the senescence of cells with the ageing of the organisms they comprise has not met with any similar degree of success, largely due to a lack of systematic investigation and the absence of the necessary biochemical tools. This review will summarise current data linking replicative senescence and organismal ageing. It will also suggest some essential tests of the cell senescence hypothesis and some necessary ground work which must be carried out before such tests can be fruitfully performed. It will not discuss the detailed molecular ‘clockwork’ controlling the decision to exit the cell cycle irreversibly because this is covered by other authors in this special issue.

AB - Replicative senescence, the irreversible loss of proliferative capacity, is a common feature of somatic cells derived from many different species. The molecular mechanisms controlling senescence in mammals, and especially in humans, have now been substantively elucidated. However, to date, attempts to link the senescence of cells with the ageing of the organisms they comprise has not met with any similar degree of success, largely due to a lack of systematic investigation and the absence of the necessary biochemical tools. This review will summarise current data linking replicative senescence and organismal ageing. It will also suggest some essential tests of the cell senescence hypothesis and some necessary ground work which must be carried out before such tests can be fruitfully performed. It will not discuss the detailed molecular ‘clockwork’ controlling the decision to exit the cell cycle irreversibly because this is covered by other authors in this special issue.

KW - Senescence

KW - Marker

KW - Werner's syndrome

KW - Telomerase

U2 - 10.1016/j.exger.2003.09.011

DO - 10.1016/j.exger.2003.09.011

M3 - Article

VL - 38

SP - 1319

EP - 1326

JO - Experimental Gerontology

JF - Experimental Gerontology

SN - 0531-5565

IS - 11-12

ER -