Biomaterials/Cryogels

Sergey Mikhalovsky, Irina Savina

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNChapter

Abstract

In this article, synthesis, mechanical and structural properties of polymeric cryogels, and their composites – materials produced by polymerization in a frozen solvent used as a porogen – are described. The analysis of their porosity and pore structure studied using electron microscopy, confocal laser scanning microscopy, and microcomputed tomography, established their highly interconnected macroporous structure with pore size in the range of 10–200 μm suitable for cell accommodation and growth. The unique interconnecting macroporous structure of cryogels combined with their mechanical strength and ability to be repeatedly hydrated and dehydrated without losing their structural integrity make these materials an attractive object of studies for potential applications in bioseparations and tissue engineering. Examples of such applications for molecular and cell separation and cell growth are discussed. Assessment of cryogel biocompatibility bothin vitroandin vivoconfirms that these materials are very promising candidates for application in the emerging area of regenerative medicine.
Original languageEnglish
Title of host publicationReference module in biomedical sciences
EditorsMichael Caplan
Place of PublicationAmsterdam
PublisherElsevier
ISBN (Print)9780128012383
Publication statusPublished - 1 Dec 2014

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Cryogels
Biocompatible Materials
Bioelectric potentials
Cell growth
Structural integrity
Pore structure
Biocompatibility
Tissue engineering
Electron microscopy
Pore size
Strength of materials
Tomography
Structural properties
Microscopic examination
Porosity
Polymerization
Scanning
Mechanical properties
Lasers
Composite materials

Cite this

Mikhalovsky, S., & Savina, I. (2014). Biomaterials/Cryogels. In M. Caplan (Ed.), Reference module in biomedical sciences Amsterdam: Elsevier.
Mikhalovsky, Sergey ; Savina, Irina. / Biomaterials/Cryogels. Reference module in biomedical sciences. editor / Michael Caplan. Amsterdam : Elsevier, 2014.
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Mikhalovsky, S & Savina, I 2014, Biomaterials/Cryogels. in M Caplan (ed.), Reference module in biomedical sciences. Elsevier, Amsterdam.

Biomaterials/Cryogels. / Mikhalovsky, Sergey; Savina, Irina.

Reference module in biomedical sciences. ed. / Michael Caplan. Amsterdam : Elsevier, 2014.

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNChapter

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T1 - Biomaterials/Cryogels

AU - Mikhalovsky, Sergey

AU - Savina, Irina

PY - 2014/12/1

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AB - In this article, synthesis, mechanical and structural properties of polymeric cryogels, and their composites – materials produced by polymerization in a frozen solvent used as a porogen – are described. The analysis of their porosity and pore structure studied using electron microscopy, confocal laser scanning microscopy, and microcomputed tomography, established their highly interconnected macroporous structure with pore size in the range of 10–200 μm suitable for cell accommodation and growth. The unique interconnecting macroporous structure of cryogels combined with their mechanical strength and ability to be repeatedly hydrated and dehydrated without losing their structural integrity make these materials an attractive object of studies for potential applications in bioseparations and tissue engineering. Examples of such applications for molecular and cell separation and cell growth are discussed. Assessment of cryogel biocompatibility bothin vitroandin vivoconfirms that these materials are very promising candidates for application in the emerging area of regenerative medicine.

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Mikhalovsky S, Savina I. Biomaterials/Cryogels. In Caplan M, editor, Reference module in biomedical sciences. Amsterdam: Elsevier. 2014