Bioactive bacterial cellulose sulfate electrospun nanofibers for tissue engineering applications

Vivekanandan Palaninathan, Sreejith Raveendran, Ankit K. Rochani, Neha Chauhan, Yasushi Sakamoto, Tomofumi Ukai, Toru Maekawa, D. Sakthi Kumar

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Cellulosic materials have been of tremendous importance to mankind since its discovery due to its superior properties and its abundance in nature. Recently, an increase in demand for alternate green materials has rekindled the interest for cellulosic materials. Here, bacterial cellulose has been functionalized with sulfate groups through acetosulfation to gain solubility in aqueous media, which provides access to several applications. The cell viability, antioxidant, and hemocompatibility assays have verified the biocompatible and antioxidant characteristics of bacterial cellulose sulfate (BCS) in both in vitro and ex vivo conditions. Further, novel BCS/polyvinyl alcohol nanofibers were fabricated by simple electrospinning route to engineer ultrafine nanoscale fibers. The biological evaluation of BCS/polyvinyl alcohol nanofiber scaffolds was done using L929 mouse fibroblast cells, which confirmed that these nanofibers are excellent matrices for cell adhesion and proliferation.

Original languageEnglish
Pages (from-to)1634-1645
Number of pages12
JournalJournal of Tissue Engineering and Regenerative Medicine
Volume12
Issue number7
DOIs
Publication statusPublished - 1 Jul 2018

Fingerprint

Nanofibers
Tissue Engineering
Tissue engineering
Polyvinyl Alcohol
Cellulose
Polyvinyl alcohols
Antioxidants
Cells
Cell adhesion
Cell proliferation
Electrospinning
Fibroblasts
Scaffolds
Solubility
Sulfates
Assays
Cell Survival
Cell Proliferation
Engineers
Fibers

Keywords

  • antioxidants
  • bacterial cellulose
  • bacterial cellulose sulfate
  • electrospinning
  • nanofibers
  • oxidative stress

Cite this

Palaninathan, V., Raveendran, S., Rochani, A. K., Chauhan, N., Sakamoto, Y., Ukai, T., ... Kumar, D. S. (2018). Bioactive bacterial cellulose sulfate electrospun nanofibers for tissue engineering applications. Journal of Tissue Engineering and Regenerative Medicine, 12(7), 1634-1645. https://doi.org/10.1002/term.2689
Palaninathan, Vivekanandan ; Raveendran, Sreejith ; Rochani, Ankit K. ; Chauhan, Neha ; Sakamoto, Yasushi ; Ukai, Tomofumi ; Maekawa, Toru ; Kumar, D. Sakthi. / Bioactive bacterial cellulose sulfate electrospun nanofibers for tissue engineering applications. In: Journal of Tissue Engineering and Regenerative Medicine. 2018 ; Vol. 12, No. 7. pp. 1634-1645.
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Palaninathan, V, Raveendran, S, Rochani, AK, Chauhan, N, Sakamoto, Y, Ukai, T, Maekawa, T & Kumar, DS 2018, 'Bioactive bacterial cellulose sulfate electrospun nanofibers for tissue engineering applications', Journal of Tissue Engineering and Regenerative Medicine, vol. 12, no. 7, pp. 1634-1645. https://doi.org/10.1002/term.2689

Bioactive bacterial cellulose sulfate electrospun nanofibers for tissue engineering applications. / Palaninathan, Vivekanandan; Raveendran, Sreejith; Rochani, Ankit K.; Chauhan, Neha; Sakamoto, Yasushi; Ukai, Tomofumi; Maekawa, Toru; Kumar, D. Sakthi.

In: Journal of Tissue Engineering and Regenerative Medicine, Vol. 12, No. 7, 01.07.2018, p. 1634-1645.

Research output: Contribution to journalArticleResearchpeer-review

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