Basilar membrane measurements from wild type, prestin 499, and prestin KO mice

Thomas Weddell; Marcia Mellado-Lagarde; Victoria Lukashkina; Andrei Lukashkin; Jian Zuo; Ian Russell

doi:10.1063/1.3658126

Basilar membrane measurements from wild type, prestin 499, and prestin KO mice

Thomas Weddell, Marcia Mellado-Lagarde, Victoria Lukashkina, Andrei Lukashkin, Jian Zuo, Ian Russell

Research output: Chapter in Book/Conference proceeding with ISSN or ISBN › Conference contribution with ISSN or ISBN › peer-review

Abstract

It has been predicted that a nonfunctional prestin in the mammalian cochlea would produce a basilar membrane response at lower characteristic frequency, as we see in the prestin knock-out mouse, but with a reduced sensitivity that would reflect an enhanced coupling between basilar membrane and reticular lamina and inner hair cell stereocilia. We demonstrate here that this is the case in measurements from the 499 mouse where prestin in the lateral membrane of the outer hair cells is present but effectively silenced.

Original language	English
Title of host publication	What Fire is in Mine Ears
Subtitle of host publication	Progress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop
Pages	432-433
Number of pages	2
DOIs	https://doi.org/10.1063/1.3658126
Publication status	Published - 12 Dec 2011
Event	11th International Mechanics of Hearing Workshop - What Fire is in Mine Ears: Progress in Auditory Biomechanics - Williamstown, MA, United States Duration: 16 Jul 2011 → 22 Jul 2011

Publication series

Name	AIP Conference Proceedings
Volume	1403
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Workshop

Workshop	11th International Mechanics of Hearing Workshop - What Fire is in Mine Ears: Progress in Auditory Biomechanics
Country/Territory	United States
City	Williamstown, MA
Period	16/07/11 → 22/07/11

Keywords

amplifier
basilar membrane
prestin 499 mouse

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10.1063/1.3658126

Cite this

Weddell, T., Mellado-Lagarde, M., Lukashkina, V., Lukashkin, A., Zuo, J., & Russell, I. (2011). Basilar membrane measurements from wild type, prestin 499, and prestin KO mice. In What Fire is in Mine Ears: Progress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop (pp. 432-433). (AIP Conference Proceedings; Vol. 1403). https://doi.org/10.1063/1.3658126

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title = "Basilar membrane measurements from wild type, prestin 499, and prestin KO mice",

abstract = "It has been predicted that a nonfunctional prestin in the mammalian cochlea would produce a basilar membrane response at lower characteristic frequency, as we see in the prestin knock-out mouse, but with a reduced sensitivity that would reflect an enhanced coupling between basilar membrane and reticular lamina and inner hair cell stereocilia. We demonstrate here that this is the case in measurements from the 499 mouse where prestin in the lateral membrane of the outer hair cells is present but effectively silenced.",

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author = "Thomas Weddell and Marcia Mellado-Lagarde and Victoria Lukashkina and Andrei Lukashkin and Jian Zuo and Ian Russell",

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Weddell, T, Mellado-Lagarde, M, Lukashkina, V, Lukashkin, A, Zuo, J & Russell, I 2011, Basilar membrane measurements from wild type, prestin 499, and prestin KO mice. in What Fire is in Mine Ears: Progress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop. AIP Conference Proceedings, vol. 1403, pp. 432-433, 11th International Mechanics of Hearing Workshop - What Fire is in Mine Ears: Progress in Auditory Biomechanics, Williamstown, MA, United States, 16/07/11. https://doi.org/10.1063/1.3658126

Basilar membrane measurements from wild type, prestin 499, and prestin KO mice. / Weddell, Thomas; Mellado-Lagarde, Marcia; Lukashkina, Victoria et al.
What Fire is in Mine Ears: Progress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop. 2011. p. 432-433 (AIP Conference Proceedings; Vol. 1403).

Research output: Chapter in Book/Conference proceeding with ISSN or ISBN › Conference contribution with ISSN or ISBN › peer-review

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AU - Weddell, Thomas

AU - Mellado-Lagarde, Marcia

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AU - Zuo, Jian

AU - Russell, Ian

PY - 2011/12/12

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N2 - It has been predicted that a nonfunctional prestin in the mammalian cochlea would produce a basilar membrane response at lower characteristic frequency, as we see in the prestin knock-out mouse, but with a reduced sensitivity that would reflect an enhanced coupling between basilar membrane and reticular lamina and inner hair cell stereocilia. We demonstrate here that this is the case in measurements from the 499 mouse where prestin in the lateral membrane of the outer hair cells is present but effectively silenced.

AB - It has been predicted that a nonfunctional prestin in the mammalian cochlea would produce a basilar membrane response at lower characteristic frequency, as we see in the prestin knock-out mouse, but with a reduced sensitivity that would reflect an enhanced coupling between basilar membrane and reticular lamina and inner hair cell stereocilia. We demonstrate here that this is the case in measurements from the 499 mouse where prestin in the lateral membrane of the outer hair cells is present but effectively silenced.

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M3 - Conference contribution with ISSN or ISBN

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ER -

Basilar membrane measurements from wild type, prestin 499, and prestin KO mice

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Workshop

Keywords

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