Basilar membrane measurements from wild type, prestin 499, and prestin KO mice

Thomas Weddell, Marcia Mellado-Lagarde, Victoria Lukashkina, Andrei Lukashkin, Jian Zuo, Ian Russell

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNConference contribution with ISSN or ISBN

Abstract

It has been predicted that a nonfunctional prestin in the mammalian cochlea would produce a basilar membrane response at lower characteristic frequency, as we see in the prestin knock-out mouse, but with a reduced sensitivity that would reflect an enhanced coupling between basilar membrane and reticular lamina and inner hair cell stereocilia. We demonstrate here that this is the case in measurements from the 499 mouse where prestin in the lateral membrane of the outer hair cells is present but effectively silenced.

Original languageEnglish
Title of host publicationWhat Fire is in Mine Ears
Subtitle of host publicationProgress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop
Pages432-433
Number of pages2
DOIs
Publication statusPublished - 12 Dec 2011
Event11th International Mechanics of Hearing Workshop - What Fire is in Mine Ears: Progress in Auditory Biomechanics - Williamstown, MA, United States
Duration: 16 Jul 201122 Jul 2011

Publication series

NameAIP Conference Proceedings
Volume1403
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Workshop

Workshop11th International Mechanics of Hearing Workshop - What Fire is in Mine Ears: Progress in Auditory Biomechanics
CountryUnited States
CityWilliamstown, MA
Period16/07/1122/07/11

Keywords

  • amplifier
  • basilar membrane
  • prestin 499 mouse

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