Azo compounds in colon-specific drug delivery

M. Roldo, E. Barbu, J.F. Brown, D.W. Laight, John Smart, J. Tsibouklis

Research output: Contribution to journalArticle

Abstract

Azo compounds have the potential to act as drug carriers that facilitate the selective release of therapeutic agents to the colon, and also to effect the oral administration of those macromolecular drugs that require colon-specific drug delivery. With some further research-driven refinements, these materials may lead to more efficient treatments for local conditions, such as colonic cancer or inflammatory bowel disease. This article provides an overview of the azo-based systems developed to date, identifies the requirements for an ideal carrier, and highlights the directions for further developments in the field of azo group-facilitated colonic delivery.
Original languageEnglish
Pages (from-to)547-560
Number of pages14
JournalExpert Opinion on Drug Delivery
Volume4
Issue number5
DOIs
Publication statusPublished - Sep 2007

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    Roldo, M., Barbu, E., Brown, J. F., Laight, D. W., Smart, J., & Tsibouklis, J. (2007). Azo compounds in colon-specific drug delivery. Expert Opinion on Drug Delivery, 4(5), 547-560. https://doi.org/10.1517/17425247.4.5.547