Autogenic drainage and assisted autogenic drainage in children with cystic fibrosis: A systematic review

Lieselotte Corten, Jennifer Jelsma, Brenda Morrow

    Research output: Chapter in Book/Conference proceeding with ISSN or ISBNConference contribution with ISSN or ISBNpeer-review


    Chest physiotherapy is considered an essential part of symptomatic, multidisciplinary management in cystic fibrosis (CF), as it facilitates clearance of viscous pulmonary secretions.


    To determine the effect of autogenic drainage (AD) and assisted autogenic drainage (AAD) compared to no; sham; or other types of chest physiotherapy in children with CF.


    Six databases, and were searched. We included randomized controlled trials, quasi-randomized controlled trials and randomized cross-over trials on AD and AAD in children younger than 18 years, diagnosed with CF. One author conducted the database search. Titles, abstracts and data were evaluated by two independent reviewers with agreement by discussion and consensus.


    A total of 126 titles were screened, of which seven were eligible. However, only two studies made a clear distinction between pediatric (ntotal = 47; n1 = 36 & n2 = 9) and adult data, and were therefore analyzed. We were unable to perform a meta-analysis, as only one study clearly indicated separate results for the different periods of the cross-over. Based on the pediatric data of this one study, participants who received AD had a significant improvement in Huang scores; a tendency to have fewer hospital admissions during one year when compared to postural drainage; and a clear preference for AD by participants. One other study reported pediatric data, however no significance levels were provided.


    Due to the lack of pediatric-specific randomized controlled trials, small sample sizes and unclear risk of bias of most studies, we were unable to determine the efficacy and/or safety of AD and AAD in children with CF.

    Original languageEnglish
    Title of host publicationAbstracts of the 38th European Cystic Fibrosis Conference
    Publication statusPublished - 5 Jun 2015

    Publication series

    NameJournal of Cystic Fibrosis
    ISSN (Print)1569-1993


    • cystic fibrosis
    • Chest physiotherapy
    • Paediatric


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