Autogenic drainage and assisted autogenic drainage in children with cystic fibrosis: A systematic review

Lieselotte Corten, Jennifer Jelsma, Brenda Morrow

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNConference contribution with ISSN or ISBN

Abstract

Chest physiotherapy is considered an essential part of symptomatic, multidisciplinary management in cystic fibrosis (CF), as it facilitates clearance of viscous pulmonary secretions.

Objectives

To determine the effect of autogenic drainage (AD) and assisted autogenic drainage (AAD) compared to no; sham; or other types of chest physiotherapy in children with CF.

Methods

Six databases, clinicaltrials.gov and pactr.org were searched. We included randomized controlled trials, quasi-randomized controlled trials and randomized cross-over trials on AD and AAD in children younger than 18 years, diagnosed with CF. One author conducted the database search. Titles, abstracts and data were evaluated by two independent reviewers with agreement by discussion and consensus.

Results

A total of 126 titles were screened, of which seven were eligible. However, only two studies made a clear distinction between pediatric (ntotal = 47; n1 = 36 & n2 = 9) and adult data, and were therefore analyzed. We were unable to perform a meta-analysis, as only one study clearly indicated separate results for the different periods of the cross-over. Based on the pediatric data of this one study, participants who received AD had a significant improvement in Huang scores; a tendency to have fewer hospital admissions during one year when compared to postural drainage; and a clear preference for AD by participants. One other study reported pediatric data, however no significance levels were provided.

Conclusion

Due to the lack of pediatric-specific randomized controlled trials, small sample sizes and unclear risk of bias of most studies, we were unable to determine the efficacy and/or safety of AD and AAD in children with CF.

Original languageEnglish
Title of host publicationAbstracts of the 38th European Cystic Fibrosis Conference
PublisherElsevier
PagesS100
Volume14
DOIs
Publication statusPublished - 5 Jun 2015

Publication series

NameJournal of Cystic Fibrosis
PublisherElsevier
ISSN (Print)1569-1993

Fingerprint

Cystic Fibrosis
Drainage
Pediatrics
Randomized Controlled Trials
Postural Drainage
Thorax
Databases
Sample Size
Cross-Over Studies
Meta-Analysis
Safety
Lung

Keywords

  • cystic fibrosis
  • Chest physiotherapy
  • Paediatric

Cite this

Corten, L., Jelsma, J., & Morrow, B. (2015). Autogenic drainage and assisted autogenic drainage in children with cystic fibrosis: A systematic review. In Abstracts of the 38th European Cystic Fibrosis Conference (Vol. 14, pp. S100). (Journal of Cystic Fibrosis). Elsevier. https://doi.org/10.1016/S1569-1993(15)30341-6
Corten, Lieselotte ; Jelsma, Jennifer ; Morrow, Brenda. / Autogenic drainage and assisted autogenic drainage in children with cystic fibrosis : A systematic review. Abstracts of the 38th European Cystic Fibrosis Conference. Vol. 14 Elsevier, 2015. pp. S100 (Journal of Cystic Fibrosis).
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abstract = "Chest physiotherapy is considered an essential part of symptomatic, multidisciplinary management in cystic fibrosis (CF), as it facilitates clearance of viscous pulmonary secretions.ObjectivesTo determine the effect of autogenic drainage (AD) and assisted autogenic drainage (AAD) compared to no; sham; or other types of chest physiotherapy in children with CF.MethodsSix databases, clinicaltrials.gov and pactr.org were searched. We included randomized controlled trials, quasi-randomized controlled trials and randomized cross-over trials on AD and AAD in children younger than 18 years, diagnosed with CF. One author conducted the database search. Titles, abstracts and data were evaluated by two independent reviewers with agreement by discussion and consensus.ResultsA total of 126 titles were screened, of which seven were eligible. However, only two studies made a clear distinction between pediatric (ntotal = 47; n1 = 36 & n2 = 9) and adult data, and were therefore analyzed. We were unable to perform a meta-analysis, as only one study clearly indicated separate results for the different periods of the cross-over. Based on the pediatric data of this one study, participants who received AD had a significant improvement in Huang scores; a tendency to have fewer hospital admissions during one year when compared to postural drainage; and a clear preference for AD by participants. One other study reported pediatric data, however no significance levels were provided.ConclusionDue to the lack of pediatric-specific randomized controlled trials, small sample sizes and unclear risk of bias of most studies, we were unable to determine the efficacy and/or safety of AD and AAD in children with CF.",
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Corten, L, Jelsma, J & Morrow, B 2015, Autogenic drainage and assisted autogenic drainage in children with cystic fibrosis: A systematic review. in Abstracts of the 38th European Cystic Fibrosis Conference. vol. 14, Journal of Cystic Fibrosis, Elsevier, pp. S100. https://doi.org/10.1016/S1569-1993(15)30341-6

Autogenic drainage and assisted autogenic drainage in children with cystic fibrosis : A systematic review. / Corten, Lieselotte; Jelsma, Jennifer; Morrow, Brenda.

Abstracts of the 38th European Cystic Fibrosis Conference. Vol. 14 Elsevier, 2015. p. S100 (Journal of Cystic Fibrosis).

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNConference contribution with ISSN or ISBN

TY - GEN

T1 - Autogenic drainage and assisted autogenic drainage in children with cystic fibrosis

T2 - A systematic review

AU - Corten, Lieselotte

AU - Jelsma, Jennifer

AU - Morrow, Brenda

PY - 2015/6/5

Y1 - 2015/6/5

N2 - Chest physiotherapy is considered an essential part of symptomatic, multidisciplinary management in cystic fibrosis (CF), as it facilitates clearance of viscous pulmonary secretions.ObjectivesTo determine the effect of autogenic drainage (AD) and assisted autogenic drainage (AAD) compared to no; sham; or other types of chest physiotherapy in children with CF.MethodsSix databases, clinicaltrials.gov and pactr.org were searched. We included randomized controlled trials, quasi-randomized controlled trials and randomized cross-over trials on AD and AAD in children younger than 18 years, diagnosed with CF. One author conducted the database search. Titles, abstracts and data were evaluated by two independent reviewers with agreement by discussion and consensus.ResultsA total of 126 titles were screened, of which seven were eligible. However, only two studies made a clear distinction between pediatric (ntotal = 47; n1 = 36 & n2 = 9) and adult data, and were therefore analyzed. We were unable to perform a meta-analysis, as only one study clearly indicated separate results for the different periods of the cross-over. Based on the pediatric data of this one study, participants who received AD had a significant improvement in Huang scores; a tendency to have fewer hospital admissions during one year when compared to postural drainage; and a clear preference for AD by participants. One other study reported pediatric data, however no significance levels were provided.ConclusionDue to the lack of pediatric-specific randomized controlled trials, small sample sizes and unclear risk of bias of most studies, we were unable to determine the efficacy and/or safety of AD and AAD in children with CF.

AB - Chest physiotherapy is considered an essential part of symptomatic, multidisciplinary management in cystic fibrosis (CF), as it facilitates clearance of viscous pulmonary secretions.ObjectivesTo determine the effect of autogenic drainage (AD) and assisted autogenic drainage (AAD) compared to no; sham; or other types of chest physiotherapy in children with CF.MethodsSix databases, clinicaltrials.gov and pactr.org were searched. We included randomized controlled trials, quasi-randomized controlled trials and randomized cross-over trials on AD and AAD in children younger than 18 years, diagnosed with CF. One author conducted the database search. Titles, abstracts and data were evaluated by two independent reviewers with agreement by discussion and consensus.ResultsA total of 126 titles were screened, of which seven were eligible. However, only two studies made a clear distinction between pediatric (ntotal = 47; n1 = 36 & n2 = 9) and adult data, and were therefore analyzed. We were unable to perform a meta-analysis, as only one study clearly indicated separate results for the different periods of the cross-over. Based on the pediatric data of this one study, participants who received AD had a significant improvement in Huang scores; a tendency to have fewer hospital admissions during one year when compared to postural drainage; and a clear preference for AD by participants. One other study reported pediatric data, however no significance levels were provided.ConclusionDue to the lack of pediatric-specific randomized controlled trials, small sample sizes and unclear risk of bias of most studies, we were unable to determine the efficacy and/or safety of AD and AAD in children with CF.

KW - cystic fibrosis

KW - Chest physiotherapy

KW - Paediatric

U2 - 10.1016/S1569-1993(15)30341-6

DO - 10.1016/S1569-1993(15)30341-6

M3 - Conference contribution with ISSN or ISBN

VL - 14

T3 - Journal of Cystic Fibrosis

SP - S100

BT - Abstracts of the 38th European Cystic Fibrosis Conference

PB - Elsevier

ER -

Corten L, Jelsma J, Morrow B. Autogenic drainage and assisted autogenic drainage in children with cystic fibrosis: A systematic review. In Abstracts of the 38th European Cystic Fibrosis Conference. Vol. 14. Elsevier. 2015. p. S100. (Journal of Cystic Fibrosis). https://doi.org/10.1016/S1569-1993(15)30341-6