Antiproton induced DNA damage: Proton like in flight, carbon-ion like near rest

J. N. Kavanagh; F. J. Currell; D. J. Timson; K. I. Savage; D. J. Richard; S. J. McMahon; O. Hartley; G. A.P. Cirrone; F. Romano; K. M. Prise; N. Bassler; M. H. Holzscheiter; G. Schettino

doi:10.1038/srep01770

Antiproton induced DNA damage: Proton like in flight, carbon-ion like near rest

J. N. Kavanagh, F. J. Currell, D. J. Timson, K. I. Savage, D. J. Richard, S. J. McMahon, O. Hartley, G. A.P. Cirrone, F. Romano, K. M. Prise, N. Bassler, M. H. Holzscheiter, G. Schettino

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Abstract

Biological validation of new radiotherapy modalities is essential to understand their therapeutic potential. Antiprotons have been proposed for cancer therapy due to enhanced dose deposition provided by antiproton-nucleon annihilation. We assessed cellular DNA damage and relative biological effectiveness (RBE) of a clinically relevant antiproton beam. Despite a modest LET (∼19 keV/μm), antiproton spread out Bragg peak (SOBP) irradiation caused significant residual γ-H2AX foci compared to X-ray, proton and antiproton plateau irradiation. RBE of ∼1.48 in the SOBP and ∼1 in the plateau were measured and used for a qualitative effective dose curve comparison with proton and carbon-ions. Foci in the antiproton SOBP were larger and more structured compared to X-rays, protons and carbon-ions. This is likely due to overlapping particle tracks near the annihilation vertex, creating spatially correlated DNA lesions. No biological effects were observed at 28-42 mm away from the primary beam suggesting minimal risk from long-range secondary particles.

Original language	English
Article number	1770
Journal	Scientific Reports
Volume	3
DOIs	https://doi.org/10.1038/srep01770
Publication status	Published - 11 Jun 2013

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@article{dbd3cac8ef5d41359980256c30e42573,

title = "Antiproton induced DNA damage: Proton like in flight, carbon-ion like near rest",

abstract = "Biological validation of new radiotherapy modalities is essential to understand their therapeutic potential. Antiprotons have been proposed for cancer therapy due to enhanced dose deposition provided by antiproton-nucleon annihilation. We assessed cellular DNA damage and relative biological effectiveness (RBE) of a clinically relevant antiproton beam. Despite a modest LET (∼19 keV/μm), antiproton spread out Bragg peak (SOBP) irradiation caused significant residual γ-H2AX foci compared to X-ray, proton and antiproton plateau irradiation. RBE of ∼1.48 in the SOBP and ∼1 in the plateau were measured and used for a qualitative effective dose curve comparison with proton and carbon-ions. Foci in the antiproton SOBP were larger and more structured compared to X-rays, protons and carbon-ions. This is likely due to overlapping particle tracks near the annihilation vertex, creating spatially correlated DNA lesions. No biological effects were observed at 28-42 mm away from the primary beam suggesting minimal risk from long-range secondary particles.",

author = "Kavanagh, {J. N.} and Currell, {F. J.} and Timson, {D. J.} and Savage, {K. I.} and Richard, {D. J.} and McMahon, {S. J.} and O. Hartley and Cirrone, {G. A.P.} and F. Romano and Prise, {K. M.} and N. Bassler and Holzscheiter, {M. H.} and G. Schettino",

year = "2013",

month = jun,

day = "11",

doi = "10.1038/srep01770",

language = "English",

volume = "3",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "Nature Publishing Group UK",

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T2 - Proton like in flight, carbon-ion like near rest

AU - Kavanagh, J. N.

AU - Currell, F. J.

AU - Timson, D. J.

AU - Savage, K. I.

AU - Richard, D. J.

AU - McMahon, S. J.

AU - Hartley, O.

AU - Cirrone, G. A.P.

AU - Romano, F.

AU - Prise, K. M.

AU - Bassler, N.

AU - Holzscheiter, M. H.

AU - Schettino, G.

PY - 2013/6/11

Y1 - 2013/6/11

N2 - Biological validation of new radiotherapy modalities is essential to understand their therapeutic potential. Antiprotons have been proposed for cancer therapy due to enhanced dose deposition provided by antiproton-nucleon annihilation. We assessed cellular DNA damage and relative biological effectiveness (RBE) of a clinically relevant antiproton beam. Despite a modest LET (∼19 keV/μm), antiproton spread out Bragg peak (SOBP) irradiation caused significant residual γ-H2AX foci compared to X-ray, proton and antiproton plateau irradiation. RBE of ∼1.48 in the SOBP and ∼1 in the plateau were measured and used for a qualitative effective dose curve comparison with proton and carbon-ions. Foci in the antiproton SOBP were larger and more structured compared to X-rays, protons and carbon-ions. This is likely due to overlapping particle tracks near the annihilation vertex, creating spatially correlated DNA lesions. No biological effects were observed at 28-42 mm away from the primary beam suggesting minimal risk from long-range secondary particles.

AB - Biological validation of new radiotherapy modalities is essential to understand their therapeutic potential. Antiprotons have been proposed for cancer therapy due to enhanced dose deposition provided by antiproton-nucleon annihilation. We assessed cellular DNA damage and relative biological effectiveness (RBE) of a clinically relevant antiproton beam. Despite a modest LET (∼19 keV/μm), antiproton spread out Bragg peak (SOBP) irradiation caused significant residual γ-H2AX foci compared to X-ray, proton and antiproton plateau irradiation. RBE of ∼1.48 in the SOBP and ∼1 in the plateau were measured and used for a qualitative effective dose curve comparison with proton and carbon-ions. Foci in the antiproton SOBP were larger and more structured compared to X-rays, protons and carbon-ions. This is likely due to overlapping particle tracks near the annihilation vertex, creating spatially correlated DNA lesions. No biological effects were observed at 28-42 mm away from the primary beam suggesting minimal risk from long-range secondary particles.

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DO - 10.1038/srep01770

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SN - 2045-2322

VL - 3

JO - Scientific Reports

JF - Scientific Reports

M1 - 1770

ER -

Antiproton induced DNA damage: Proton like in flight, carbon-ion like near rest

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