An adsorbent monolith device to augment the removal of uraemic toxins during haemodialysis

Susan Sandeman; Carol Howell; Gary Phillips; Yishan Zheng; Guy Standen; Robert Pletzenauer; Andrew Pletzenauer; Kolitha Basnayake; Boyd Owen; Stephen Holt; Sergey Mikhalovsky

doi:10.1007/s10856-014-5173-9

An adsorbent monolith device to augment the removal of uraemic toxins during haemodialysis

Susan Sandeman, Carol Howell, Gary Phillips, Yishan Zheng, Guy Standen, Robert Pletzenauer, Andrew Pletzenauer, Kolitha Basnayake, Boyd Owen, Stephen Holt, Sergey Mikhalovsky

Research output: Contribution to journal › Article › peer-review

Abstract

Adsorbents designed with porosity which allows the removal of protein bound and high molecular weight uraemic toxins may improve the effectiveness of haemodialysis treatment of chronic kidney disease (CKD). A nanoporous activated carbon monolith prototype designed for direct blood contact was first assessed for its capacity to remove albumin bound marker toxins indoxyl sulphate (IS), p-cresyl sulphate (p-CS) and high molecular weight cytokine interleukin-6 in spiked healthy donor studies. Haemodialysis patient blood samples were then used to measure the presence of these markers in pre- and post-dialysis blood and their removal by adsorbent recirculation of post-dialysis blood samples. Nanopores (20-100 nm) were necessary for marker uraemic toxin removal during in vitro studies. Limited removal of IS and p-CS occurred during haemodialysis, whereas almost complete removal occurred following perfusion through the carbon monoliths suggesting a key role for such adsorbent therapies in CKD patient care.

Original language	English
Pages (from-to)	1589-1597
Number of pages	9
Journal	Journal of Materials Science: Materials in Medicine
Volume	25
Issue number	6
DOIs	https://doi.org/10.1007/s10856-014-5173-9
Publication status	Published - 30 Jun 2014

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Susan Sandeman
- S.Sandemanbrighton.acuk
- School of Applied Sciences - Professor of Biomaterials and Tissue Eng.
- Applied Chemical Sciences Research Excellence Group
- Centre for Lifelong Health
- Centre for Regenerative Medicine and Devices
Person: Academic

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title = "An adsorbent monolith device to augment the removal of uraemic toxins during haemodialysis",

abstract = "Adsorbents designed with porosity which allows the removal of protein bound and high molecular weight uraemic toxins may improve the effectiveness of haemodialysis treatment of chronic kidney disease (CKD). A nanoporous activated carbon monolith prototype designed for direct blood contact was first assessed for its capacity to remove albumin bound marker toxins indoxyl sulphate (IS), p-cresyl sulphate (p-CS) and high molecular weight cytokine interleukin-6 in spiked healthy donor studies. Haemodialysis patient blood samples were then used to measure the presence of these markers in pre- and post-dialysis blood and their removal by adsorbent recirculation of post-dialysis blood samples. Nanopores (20-100 nm) were necessary for marker uraemic toxin removal during in vitro studies. Limited removal of IS and p-CS occurred during haemodialysis, whereas almost complete removal occurred following perfusion through the carbon monoliths suggesting a key role for such adsorbent therapies in CKD patient care.",

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AU - Howell, Carol

AU - Phillips, Gary

AU - Zheng, Yishan

AU - Standen, Guy

AU - Pletzenauer, Robert

AU - Pletzenauer, Andrew

AU - Basnayake, Kolitha

AU - Owen, Boyd

AU - Holt, Stephen

AU - Mikhalovsky, Sergey

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AB - Adsorbents designed with porosity which allows the removal of protein bound and high molecular weight uraemic toxins may improve the effectiveness of haemodialysis treatment of chronic kidney disease (CKD). A nanoporous activated carbon monolith prototype designed for direct blood contact was first assessed for its capacity to remove albumin bound marker toxins indoxyl sulphate (IS), p-cresyl sulphate (p-CS) and high molecular weight cytokine interleukin-6 in spiked healthy donor studies. Haemodialysis patient blood samples were then used to measure the presence of these markers in pre- and post-dialysis blood and their removal by adsorbent recirculation of post-dialysis blood samples. Nanopores (20-100 nm) were necessary for marker uraemic toxin removal during in vitro studies. Limited removal of IS and p-CS occurred during haemodialysis, whereas almost complete removal occurred following perfusion through the carbon monoliths suggesting a key role for such adsorbent therapies in CKD patient care.

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An adsorbent monolith device to augment the removal of uraemic toxins during haemodialysis

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