Altered cofactor binding affects stability and activity of human UDP-galactose 4'-epimerase: Implications for type III galactosemia

Keyphrases

• Type III Galactosemia 100%
• UDP-galactopyranose mutase 100%
• Cofactor Binding 100%
• Nicotinamide Adenine Dinucleotide (NAD+) 66%
• Galactose 66%
• Structural Change 33%
• Thermal Stability 33%
• Enzymatic Activity 33%
• Helix 33%
• N-acetylgalactosamine 33%
• Enhanced Stability 33%
• Salt Bridge 33%
• UDP-galactose 33%
• UDP-GlcNAc 33%
• Mild Forms 33%
• Disease Causation 33%
• Emulsifying Salts 33%
• Differential Scanning Fluorimetry 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Disease 100%
• Uridine Diphosphate 100%
• Uridine Diphosphate Glucose 4 Epimerase 100%
• Galactosemia 100%
• Galactose 100%
• Sodium Chloride 50%
• N Acetylglucosamine 50%
• Thermostability 50%
• N Acetylgalactosamine 50%
• Uridine Diphosphate Galactose 50%

Biochemistry, Genetics and Molecular Biology

• Uridine Diphosphate Galactose 100%
• Wild Type 66%
• Galactose 66%
• Uridine Diphosphate 66%
• Allele 33%
• N-Acetylglucosamine 33%
• Enzyme Activity 33%
• Thermostability 33%
• N-Acetylgalactosamine 33%