Paracetamol or acetaminophen is the most widely used pharmaceutical drug in the world and recent studies have reported its progressive increase in its concentrations in aquatic compartments. Meanwhile, scientific evidence suggests that pharmaceuticals can exert some important toxic effects to non-target aquatic species, due to their chemical and biological properties. The present study aims to assess the biological responses induced by paracetamol, at environmentally relevant levels, in the blue mussel Mytilus edulis, namely focusing on reproductive parameters. After 24 days laboratory exposure, seven potential target genes were selected to investigate toxicological effects in mussel gonads, and potential disturbances of the reproductive cycle. Results show the modulation of some important reproduction-related genes: estrogen receptor 2 (ER2), vitelline envelope zona pellucida domain 9 (V9), and vitellogenin (VTG). The variation in mRNA expression of four other genes involved in apoptosis (CASP8, HSP70, BCL2 and FAS) was also investigated. Histopathological alterations caused by paracetamol, together with its potential to act as a non-traditional endocrine disruptor are discussed.
|Publication status||Published - 4 Nov 2019|
|Event||SETAC Toronto – SETAC North America 40th Annual Meeting - Toronto, Toronto, Canada|
Duration: 3 Nov 2019 → 7 Nov 2019
|Conference||SETAC Toronto – SETAC North America 40th Annual Meeting|
|Period||3/11/19 → 7/11/19|