An amphiphilic copolymer, Pluronic F127, has been deposited, by adsorption, to the skin of human volunteers and the ability of the coated skin to resist bacterial colonisation has been evaluated. In parallel, the ability of the same copolymer to act as a bacterial release agent has been evaluated. In both cases, F127 proved to be of little added value in formulations designed to suppress the bacterial colonisation of human skin.
- Bacterial-release coatings
- Pluronic F127
- In vivo evaluation
Marsh, L. H., Alexander, C., Coke, M., Dettmar, P. W., Havler, M., Nevell, T. G., Smart, J., Timmins, B., & Tsibouklis, J. (2003). Adsorbed pluronics on the skin of human volunteers: effects on bacterial adhesion. International Journal of Pharmaceutics, 251(1-2), 155-163. https://doi.org/10.1016/S0378-5173(02)00592-6