A simple method for the production of large volume 3D macroporoushydrogels for advanced biotechnological, medical and environmental applications

Irina Savina; Ganesh Ingavle; Andrew Cundy; Sergey Mikhalovsky

doi:10.1038/srep21154

A simple method for the production of large volume 3D macroporoushydrogels for advanced biotechnological, medical and environmental applications

Irina Savina, Ganesh Ingavle, Andrew Cundy, Sergey Mikhalovsky

Research output: Contribution to journal › Article › peer-review

Abstract

The development of bulk, three-dimensional (3D), macroporous polymers with high permeability,large surface areas and large volume is highly desirable for a range of applications in the biomedical,biotechnological and environmental areas. The experimental techniques currently used are limited tothe production of small size and volume cryogel material. In this work we propose a novel, versatile,simple and reproducible method for the synthesis of large volume porous polymer hydrogels bycryogelation. By controlling the freezing process of the reagent/polymer solution, large-scale 3Dmacroporous gels with wide interconnected pores (up to 200 μm in diameter) and large accessiblesurface area have been synthesized. For the first time, macroporous gels (of up to 400 ml bulk volume)with controlled porous structure were manufactured, with potential for scale up to much larger geldimensions. This method can be used for production of novel 3D multi-component macroporouscomposite materials with a uniform distribution of embedded particles. The proposed method providesbetter control of freezing conditions and thus overcomes existing drawbacks limiting production oflarge gel-based devices and matrices. The proposed method could serve as a new design concept forfunctional 3D macroporous gels and composites preparation for biomedical, biotechnological andenvironmental applications.

Original language	English
Article number	21154 (2016)
Journal	Scientific Reports
Volume	6
DOIs	https://doi.org/10.1038/srep21154
Publication status	Published - 17 Feb 2016

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This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Irina Savina
- I.N.Savinabrighton.acuk
Person: Academic

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title = "A simple method for the production of large volume 3D macroporoushydrogels for advanced biotechnological, medical and environmental applications",

abstract = "The development of bulk, three-dimensional (3D), macroporous polymers with high permeability,large surface areas and large volume is highly desirable for a range of applications in the biomedical,biotechnological and environmental areas. The experimental techniques currently used are limited tothe production of small size and volume cryogel material. In this work we propose a novel, versatile,simple and reproducible method for the synthesis of large volume porous polymer hydrogels bycryogelation. By controlling the freezing process of the reagent/polymer solution, large-scale 3Dmacroporous gels with wide interconnected pores (up to 200 μm in diameter) and large accessiblesurface area have been synthesized. For the first time, macroporous gels (of up to 400 ml bulk volume)with controlled porous structure were manufactured, with potential for scale up to much larger geldimensions. This method can be used for production of novel 3D multi-component macroporouscomposite materials with a uniform distribution of embedded particles. The proposed method providesbetter control of freezing conditions and thus overcomes existing drawbacks limiting production oflarge gel-based devices and matrices. The proposed method could serve as a new design concept forfunctional 3D macroporous gels and composites preparation for biomedical, biotechnological andenvironmental applications.",

author = "Irina Savina and Ganesh Ingavle and Andrew Cundy and Sergey Mikhalovsky",

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AU - Savina, Irina

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AU - Cundy, Andrew

AU - Mikhalovsky, Sergey

N1 - This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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N2 - The development of bulk, three-dimensional (3D), macroporous polymers with high permeability,large surface areas and large volume is highly desirable for a range of applications in the biomedical,biotechnological and environmental areas. The experimental techniques currently used are limited tothe production of small size and volume cryogel material. In this work we propose a novel, versatile,simple and reproducible method for the synthesis of large volume porous polymer hydrogels bycryogelation. By controlling the freezing process of the reagent/polymer solution, large-scale 3Dmacroporous gels with wide interconnected pores (up to 200 μm in diameter) and large accessiblesurface area have been synthesized. For the first time, macroporous gels (of up to 400 ml bulk volume)with controlled porous structure were manufactured, with potential for scale up to much larger geldimensions. This method can be used for production of novel 3D multi-component macroporouscomposite materials with a uniform distribution of embedded particles. The proposed method providesbetter control of freezing conditions and thus overcomes existing drawbacks limiting production oflarge gel-based devices and matrices. The proposed method could serve as a new design concept forfunctional 3D macroporous gels and composites preparation for biomedical, biotechnological andenvironmental applications.

AB - The development of bulk, three-dimensional (3D), macroporous polymers with high permeability,large surface areas and large volume is highly desirable for a range of applications in the biomedical,biotechnological and environmental areas. The experimental techniques currently used are limited tothe production of small size and volume cryogel material. In this work we propose a novel, versatile,simple and reproducible method for the synthesis of large volume porous polymer hydrogels bycryogelation. By controlling the freezing process of the reagent/polymer solution, large-scale 3Dmacroporous gels with wide interconnected pores (up to 200 μm in diameter) and large accessiblesurface area have been synthesized. For the first time, macroporous gels (of up to 400 ml bulk volume)with controlled porous structure were manufactured, with potential for scale up to much larger geldimensions. This method can be used for production of novel 3D multi-component macroporouscomposite materials with a uniform distribution of embedded particles. The proposed method providesbetter control of freezing conditions and thus overcomes existing drawbacks limiting production oflarge gel-based devices and matrices. The proposed method could serve as a new design concept forfunctional 3D macroporous gels and composites preparation for biomedical, biotechnological andenvironmental applications.

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A simple method for the production of large volume 3D macroporoushydrogels for advanced biotechnological, medical and environmental applications

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Irina Savina

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