A novel skin substitute biomaterial to treat full-thickness wounds in a burns emergency care

Rostislav Shevchenko, P.D. Sibbons, J.R. Sharpe, S.Elizabeth James

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNChapter

Abstract

A novel porcine collagen-based paste dermal substitute to treat full-thickness wounds has been investigated. A thin split-thickness skin graft or autologous cultured keratinocytes have been combined with dermal replacement biomaterial and applied to full-thickness wounds in a porcine wound chamber preclinical experimental model. The data obtained suggest that: (1) dermal substitute biomaterials may improve wound re-epithelialisation when combined with cultured autologous keratinocytes and (2) porcine collagen paste is able to support split-thickness skin graft survival as well as autologous cultured keratinocyte proliferation. These results demonstrate that the novel porcine collagen paste has a potential as a dermal substitute to treat acute full-thickness wounds and an application for the burns emergency care treatment.
Original languageEnglish
Title of host publicationBiodefence: advanced materials and methods for health protection
EditorsS. Mikhalovsky, A. Khajibaev
Place of PublicationNetherlands
PublisherSpringer
Pages247-255
Number of pages9
ISBN (Electronic)9789400702172
ISBN (Print)9789400702165
DOIs
Publication statusPublished - 31 Dec 2011

Publication series

NameNATO Science for Peace and Security Series A: Chemistry and Biology

Keywords

  • Permacol
  • Integra
  • Skin substitute
  • Dermal substitute
  • Cultured keratinocytes
  • Collagen
  • Animal model

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    Shevchenko, R., Sibbons, P. D., Sharpe, J. R., & James, S. E. (2011). A novel skin substitute biomaterial to treat full-thickness wounds in a burns emergency care. In S. Mikhalovsky, & A. Khajibaev (Eds.), Biodefence: advanced materials and methods for health protection (pp. 247-255). (NATO Science for Peace and Security Series A: Chemistry and Biology). Springer. https://doi.org/10.1007/978-94-007-0217-2_25