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• 2020

  Decreased 14‐3‐3 expression correlates with age‐related regional reductions in CNS dopamine and motor function in the pond snail, Lymnaea

  Morgan, L. D., Aiyaz, M., Patel, B., Arundell, M., Jennert‐Burtson, K., Hernádi, L., Overall, A., Bowler, L., O'Hare, D. & Yeoman, M., 1 Nov 2020, In: European Journal of Neuroscience. p. 1-18

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Lymnaea
  • Ponds
  • Snails
  • Dopamine
  • Protein Isoforms

• Effects of age and social isolation on murine hippocampal biochemistry and behavior

  Panossian, A., Cave, M. W., Patel, B., Brooks, E. L., Flint, M. & Yeoman, M., 28 Aug 2020, In: Mechanisms of Ageing and Development. 191, 111337.

  Research output: Contribution to journal › Article › peer-review

  • Social Isolation
  • Biochemistry
  • Corticosterone
  • Recognition (Psychology)
  • Serotonin
• 2019

  Determination of tryptophan metabolism from biological tissues and fluids using high performance liquid chromatography with simultaneous dual electrochemical detection

  Brooks, E., Mutengwa, V., Abdalla, A., Yeoman, M. & Patel, B., 16 Sep 2019, In: Analyst. 144, 20, p. 6011-6018 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • High performance liquid chromatography
  • Metabolism
  • Kynurenine
  • Tryptophan
  • liquid chromatography

• Region specific differences in the effect of propofol on the murine colon result in dysmotility

  Diss, L., Villeneuve, S., Pearce, K., Yeoman, M. & Patel, B., 29 Mar 2019, In: Autonomic Neuroscience-Basic & Clinical. 219, p. 19-24 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Propofol
  • Colon
  • Intravenous Anesthetics
  • Maintenance
  • Biological Assay

• Three-Dimensional-Printed Electrochemical Sensor for Simultaneous Dual Monitoring of Serotonin Overflow and Circular Muscle Contraction

  Bin Hamzah, H., Keattch, O., Yeoman, M., Covill, D. & Patel, B., 27 Aug 2019, In: Analytical Chemistry. 91, 18, p. 12014-12020 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Electrochemical sensors
  • Muscle
  • Serotonin
  • Monitoring
  • Sensors
• 2018

  BBSRC Pathfinder - Technology Market Assessment and Patent Landscape Analysis for use of TNF-α Antagonists in the Management of Constipation in the Elderly

  Yeoman, M. & Patel, B., 2018, 54 p.

  Research output: Book/Report › Commissioned report

  File

  • Biomedical Technology Assessment
  • Constipation
  • Elderly
  • Etanercept
  • Drug Prescriptions

• Changes in murine anorectum signaling across the life course

  Fidalgo, S., Patel, B., Ranson, R., Saffrey, J. & Yeoman, M., 30 Jul 2018, In: Neurogastroenterology and Motility. 30, 10, p. 13426-13438 13 p., e13426.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Fecal Impaction
  • Acetylcholine
  • Constipation
  • Cholinergic Agents
  • Nitric Oxide

• Does the 5-HT1A rs6295 polymorphism influence the safetyand efficacy of citalopram therapy in the oldest old?

  Scutt, G., Overall, A., Scott, R., Patel, B., Hachoumi, L., Yeoman, M. & Wright, J., 23 Apr 2018, In: Therapeutic Advances in Drug Safety. 9, 7, p. 355-366

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Citalopram
  • Aged, 80 and over
  • Genotype
  • Major Depressive Disorder
  • Bayes Theorem

• Interstitial cell network volume is reduced in the terminal bowel of ageing mice

  Gamage, P. P. K. M., Patel, B. A., Yeoman, M. S., Ranson, R. N. & Jill Saffrey, M., 25 Jul 2018, In: Journal of Cellular and Molecular Medicine.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Interstitial Cells of Cajal
  • Cell Size
  • Gastrointestinal Tract
  • Anal Canal
  • Rectum
• 2017

  The TNF-α antagonist etanercept reverses age-related decreases in colonic SERT expression and faecal output in mice

  Patel, B., Fidalgo, S., Wang, C., Parmar, L., Mandona, K., Panossian, A., Flint, M., Ranson, R. N., Saffrey, M. J. & Yeoman, M., 15 Feb 2017, In: Scientific Reports. 7, p. 1-12 12 p., 42754.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • antagonists
  • constipation
  • mice
  • water content
  • colon
• 2016

  Acute paraquat exposure impairs colonic motility by selectively attenuating nitrergic signaling in the mouse

  Diss, L., Dyball, S., Ghela, T., Golding, J., Morris, R., Robinson, S., Tucker, R., Walter, T., Young, P., Allen, M., Fidalgo, S., Gard, P., Mabley, J., Patel, B., Chatterjee, P. & Yeoman, M., 30 Jan 2016, In: Autonomic Neuroscience-Basic & Clinical. 195, p. 8-15 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Paraquat
  • Migrating Myoelectric Complexes
  • Gastrointestinal Tract
  • Colon
  • Nitroarginine

• Does Age Matter? The Impact of Rodent Age on Study Outcomes

  Jackson, S., Andrews, N., Ball, D., Bellatntuono, L., Gray, J., Hachoumi, L., Holmes, A., Latcham, J., Petrie, A., Potter, P., Rice, A., Ritchie, A., Stewart, M., Strepka, C., Yeoman, M. & Chapman, K., 15 Jun 2016, In: Laboratory Animals. 51, 2, p. 160-169 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • rodents
  • translation (genetics)
  • experimental design
  • biomedical research
  • researchers

• Electrochemical sensor for the detection of multiple reactive oxygen and nitrogen species from ageing central nervous system homogenates

  Fagan-Murphy, A., Hachoumi, L., Yeoman, M. & Patel, B., 14 Oct 2016, In: Mechanisms of Ageing and Development. 160, p. 28-31 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2015

  A switch in the mode of the sodium/calcium exchanger underlies an age-related increase in the slow afterhyperpolarization

  Scutt, G., Allen, M., Kemenes, G. & Yeoman, M., 1 Oct 2015, In: Neurobiology of Aging. 36, 10, p. 2838-2849 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Sodium-Calcium Exchanger
  • Giant Cells
  • Cellular Senescence
  • Lymnaea
  • Ponds
• 2014

  Impaired colonic motility and reduction in tachykinin signalling in the aged mouse

  Patel, B., Patel, N., Fidalgo, S., Wang, C., Ranson, R. N., Saffrey, M. J. & Yeoman, M., 31 May 2014, In: Experimental Gerontology. 53, p. 24-30 7 p.

  Research output: Contribution to journal › Article › peer-review

• 2013

  Age-related changes in melatonin release in the murine distal colon

  Diss, L. B., Robinson, S. D., Wu, Y., Fldalgo, S., Yeoman, M. & Patel, B., 30 Apr 2013, In: ACS Chemical Neuroscience. 4, 5, p. 879-887 9 p.

  Research output: Contribution to journal › Article › peer-review

  • melatonin
  • colon
  • mice
  • constipation
  • serotonin

• Biomarkers, interventions and healthy ageing

  Kenessary, A., Zhumadilov, Z., Nurgozhin, T., Kipling, D., Yeoman, M., Cox, L., Ostler, E. & Faragher, R., 25 May 2013, In: New Biotechnology. 30, 4, p. 373-377 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Healthy Aging
  • Biomarkers
  • Aging of materials
  • Morbidity
  • Pathology

• Changes in the innervation of the mouse internal anal sphincter during aging

  Wang, C., Houghton, M. J., Gamage, P. P. K. M., Collins, H. E., Patel, B., Yeoman, M., Ranson, R. N. & Saffrey, M. J., 1 May 2013, In: Neurogastroenterology and Motility. 25, 7

  Research output: Contribution to journal › Article › peer-review

  • Anal Canal
  • Nerve Fibers
  • Mucous Membrane
  • Nitric Oxide Synthase Type I
  • Substance P

• Myenteric neuron numbers are maintained in aging mouse distal colon

  Gamage, P. P. K. M., Ranson, R. N., Patel, B., Yeoman, M. & Saffrey, M. J., 20 Mar 2013, In: Neurogastroenterology and Motility. 25, 7

  Research output: Contribution to journal › Article › peer-review

  • Colon
  • Nitric Oxide Synthase Type I
  • Neurons
  • Nerve Fibers
  • Nitrergic Neurons
• 2012

  Age-related change in cholinergic and nitrergic signaling in the mouse rectum

  Patel, B., Fidalgo, S., Ranson, R. N., Saffrey, M. J. & Yeoman, M., 30 Sep 2012, p. 120-120. 1 p.

  Research output: Contribution to conference › Abstract

• Age-related changes in colonic motility, faecal output and the properties of faecal pellets in the mouse

  Patel, B., Patel, N., Fidalgo, S., Ranson, R. N., Saffery, J. & Yeoman, M., 30 Sep 2012, In: Neurogastroenterology and Motility. 24

  Research output: Contribution to journal › Article › peer-review

• Analysis of changes in the cells of the mouse internal anal sphincter during aging

  Saffrey, M. J., Wang, C., Gamage, P. P. K. M., Davies, H., Colyer, F., Houghton, M. J., Patel, B., Yeoman, M. & Ranson, R. N., 30 Sep 2012, p. 125-125. 1 p.

  Research output: Contribution to conference › Abstract

• Chromatographic analysis of age-related changes in mucosal serotonin transmission in the murine distal ileum

  Parmar, L., Fidalgo, S., Yeoman, M. & Patel, B., 31 Dec 2012, In: Chemistry Central Journal. 6, 1

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ileum
  • Chromatography
  • Serotonin
  • Hydroxyindoleacetic Acid
  • 5-Hydroxytryptophan

• Chromatographic assay to study the activity of multiple enzymes involved in the synthesis and metabolism of dopamine and serotonin

  Patel, B., Yeoman, M., Morgan, L. D. & Baker, H., 31 Dec 2012, In: Analyst. 137, 6, p. 1409-1415 7 p.

  Research output: Contribution to journal › Article › peer-review

• Decrease in serotonin-induced tachykinin signaling can account for age: Related reductions in the amplitude and the frequency of Colonic Migrating Motor Complexes (CMMCS) in the murine distal colon

  Patel, B., Yeoman, M., Fidalgo, S., Dhulia, P., Girdlestone, I., Ranson, R. N. & Saffrey, M. J., 30 Sep 2012, In: Neurogastroenterology and Motility. 24, p. 128-128 1 p.

  Research output: Contribution to journal › Article › peer-review

• Effect of age on mucosal serotonin signalling and circular muscle contractions in the murine rectum

  Patel, B., Parmar, L., Fidalgo, S., Wang, C., Ranson, R. N., Saffrey, M. J. & Yeoman, M., 30 Sep 2012, p. 84-84. 1 p.

  Research output: Contribution to conference › Abstract

• Insights into CNS ageing from animal models of senescence

  Yeoman, M., Scutt, G. & Faragher, R., 30 Jun 2012, In: Nature Reviews Neuroscience. 13, 6, p. 435-445 11 p.

  Research output: Contribution to journal › Article › peer-review