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• 2020

  Discovery of novel small molecule inhibitors of S100P with in vitro anti-metastatic effects on pancreatic cancer cells

  Camara, R., Ogbeni, D., Gerstmann, L., Ostovar, M., Hurer, E., Scott, M., Mahmoud, N. G., Radon, T., Crnogorac-Jurcevic, T., Patel, P., Mackenzie, L. S., Chau, D., Kirton, S. & Rossiter, S., 15 Jul 2020, In : European Journal of Medicinal Chemistry. 203, 112621.

  Research output: Contribution to journal › Article

  Open Access

  File

  • Molecules
  • Cells
  • Pancreatic Neoplasms
  • Pharmaceutical Databases
  • Calcium-Binding Proteins

• Modelling the effects of PPARβδ of innate inflammatory responses in lung tissues

  Perez Diaz, N., Lione, L., Hutter, V. & Mackenzie, L. S., 7 Jun 2020, (Accepted/In press) In : BioRxiv: Preprint Server for Biology.

  Research output: Contribution to journal › Article

  Open Access

  File

  • PPAR delta
  • Peroxisome Proliferator-Activated Receptors
  • Lung
  • Inflammation
  • 4-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide

• Use of machine learning and artificial intelligence to predict SARS-CoV-2 infection from full blood counts in a population: Use of ML and AI to predict SARS-CoV2 without PCR

  Banerjee, A., Ray, S., Vorselaars, B., Kitson, J., Mamalakis, M., Weeks, S., Baker, M. & Mackenzie, L. S., 16 Jun 2020, In : International Immunopharmacology. 86, 106705.

  Research output: Contribution to journal › Article

  Open Access

  File

  • SARS Virus
  • Artificial Intelligence
  • Machine Learning
  • Polymerase Chain Reaction
  • Infection
• 2019

  Off-target interactions as novel explantion of NSAID CV risk

  Dolan, G., MacKenzie, L., Zloh, M. & Lione, L., Apr 2019.

  Research output: Contribution to conference › Abstract

  Open Access

  File

  • Cardiovascular Agents
  • Anti-Inflammatory Agents
  • Diclofenac
  • Naproxen
  • Cytoplasmic and Nuclear Receptors

• Regulation of pulmonary artery inflamation by PPARβ/δ

  Perez Diaz, N., Lione, L., MacKenzie, L. & Hutter, V., Apr 2019.

  Research output: Contribution to conference › Abstract

  Open Access

  File

  • PPAR delta
  • GW0742
  • 4-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide
  • Pulmonary Artery
  • Inflammation
• 2018

  An overview of anti-diabetic plants used in Gabon: Pharmacology and toxicology

  Bading Taika, B., Bouckandou, M., Souza, A., Bourobou Bourobou, H. P., Mackenzie, L. & Lione, L. A., 2 Jan 2018, In : Journal of Ethnopharmacology. 216, p. 203-228 26 p.

  Research output: Contribution to journal › Article

  Open Access

  File

  • Gabon
  • pharmacology
  • toxicology
  • hyperglycemia
  • diabetes

• Predicted interactions of selected NSAIDS with hERG potassium channel using Virtual Toxlab

  Dolan, G., MacKenzie, L., Zloh, M. & Lione, L., Mar 2018.

  Research output: Contribution to conference › Abstract

  Open Access

  File

  • Potassium Channels
  • Celecoxib
  • Anti-Inflammatory Agents
  • Cardiac Arrhythmias
  • floctafenine

• The non-genomic effects of the PPARβ/δ agonist GW0742 on STZ treated rat aorta

  Perez-Diaz, N., Pushkarsky, I., Oweis, N., Lione, L. A. & Mackenzie, L., 31 Dec 2018, In : Current Molecular Pharmacology. 11, 2, p. 149-154 6 p.

  Research output: Contribution to journal › Article

  • GW0742
  • Peroxisome Proliferator-Activated Receptors
  • Aorta
  • Dilatation
  • fasudil
• 2017

  Exploration of the structural differences between safe and unsafe NSAIDs using 3D molecular similarity

  Dolan, G., MacKenzie, L. & Zloh, M., Dec 2017.

  Research output: Contribution to conference › Abstract

  Open Access

  File

  • drug
  • chlorine
  • inspection
  • protein
  • safety

• Exploration of the structural differences between “safe” and ”unsafe” NSAIDs using 3D molecular similarity: BPS ’In silico and in vitro methods in modern drug discovery

  Dolan, G., MacKenzie, L., Lione, L. & Zloh, M., 24 Apr 2017.

  Research output: Contribution to conference › Abstract

• Identifying compounds that inhibit S100P – RAGE binding as a novel therapy for pancreatic cancer

  Ogbeni, D., Camara, R., Chau, D., Patel, P., Kirton, S., MacKenzie, L. & Rossiter, S., 5 Jul 2017.

  Research output: Contribution to conference › Abstract

  Open Access

  File

• Identifying inhibitor of S100P – RAGE binding as a novel therapy for pancreatic cancer

  Ogbeni, D., Camara, R., Kirton, S., Patel, P., Crnogorac-Jurcevic, T., MacKenzie, L., Chau, D. & Rossiter, S., 5 Sep 2017.

  Research output: Contribution to conference › Abstract

  Open Access

  File

• New Drugs for Pancreatic Cancer

  Ogbeni, D., Chau, D., Patel, P., Rossiter, S. & MacKenzie, L., 13 Mar 2017.

  Research output: Contribution to conference › Abstract

  Open Access

  File

  • pancreatic neoplasms
  • new drugs
  • drugs
  • neoplasms
  • chemists

• Novel compounds for the inhibition of S100P binding with RAGE as a potential therapy for pancreatic cancer

  Ogbeni, D., Camara, R., Kirton, S., Crnogorac-Jurcevic, T., MacKenzie, L., Chau, D. & Rossiter, S., 5 Jul 2017.

  Research output: Contribution to conference › Abstract

  Open Access

  File

• This new treatment could make pancreatic cancer a manageable disease

  Ogbeni, D. & MacKenzie, L., 9 Feb 2017, The Conversation.

  Research output: Other contribution

  Open Access

• Thyroid Hormone Receptor Antagonists; from Environmental Pollution to Novel Small Molecules

  Mackenzie, L., 5 Jun 2017, Vitamins and Hormones. Litwack, G. (ed.). UK: Elsevier, Vol. 106. p. 147-162 16 p. (Vitamins and Hormones).

  Research output: Chapter in Book/Conference proceeding with ISSN or ISBN › Chapter

  • Environmental Pollution
  • Hormone Antagonists
  • Thyroid Hormone Receptors
  • Hyperthyroidism
  • Amiodarone
• 2016

  A New NO-Releasing Nanoformulation for the Treatment of Pulmonary Arterial Hypertension

  Mohamed, N. A., Ahmetaj-Shala, B., Duluc, L., Mackenzie, L., Kirkby, N. S., Reed, D. M., Lickiss, P. D., Davies, R. P., Freeman, G. & Wojciak-Stothard, B., 9 Mar 2016, In : Journal of Cardiovascular Translational Research. 9, 2, p. 162-164 3 p.

  Research output: Contribution to journal › Article

  Open Access

  File

  • Pulmonary Hypertension
  • Nitric Oxide
  • Therapeutics
  • Nanomedicine
  • Polyethylene Glycol Dimethacrylate Hydrogel

• Can NSAIDs alter thyroid hormone function?

  MacKenzie, L., 26 Apr 2016, The Atlas of Science .

  Research output: Other contribution

  Open Access

• Can NSAIDs alter Thyroid Hormone Function?

  MacKenzie, L., 28 Sep 2016.

  Research output: Contribution to conference › Abstract

• Can NSAIDs alter thyroid hormone function? Taking a multidisciplinary approach to address the off target effects of NSAIDs

  MacKenzie, L., 16 Nov 2016.

  Research output: Contribution to conference › Abstract

  • Thyroid Hormones
  • Anti-Inflammatory Agents
  • Celecoxib
  • Diclofenac
  • Pharmaceutical Preparations

• Evidence that Diclofenac and Celecoxib are thyroid hormone receptor beta antagonists

  Zloh, M., Perez-Diaz, N., Tang, L., Patel, P. & Mackenzie, L., 1 Feb 2016, In : Life Sciences. 146, p. 66-72 7 p.

  Research output: Contribution to journal › Article

  • Thyroid Hormone Receptors beta
  • Celecoxib
  • Diclofenac
  • Naproxen
  • Non-Steroidal Anti-Inflammatory Agents

• Methylglyoxal, A Metabolite Increased in Diabetes is Associated with InsulinResistance, Vascular Dysfunction and Neuropathies

  Shamsaldeen, Y. A., Mackenzie, L., Lione, L. A. & Benham, C. D., 1 Jan 2016, In : Current Drug Metabolism. 17, 4, p. 359-367 9 p.

  Research output: Contribution to journal › Article

  Open Access

  File

  • Pyruvaldehyde
  • Blood Vessels
  • Diabetes Complications
  • Hyperglycemia
  • Bibliographic Databases
• 2015

  ELISA screen of novel compounds that inhibit S100P and RAGE binding to identify new candidate drugs as a new therapy for pancreatic cancer

  Ogbeni, D., Camara, R., Chau, D., Kirton, S., Rossiter, S. & MacKenzie, L., 2015.

  Research output: Contribution to conference › Abstract

  Open Access

  File

  • Receptor for Advanced Glycation End Products
  • Pancreatic Neoplasms
  • Enzyme-Linked Immunosorbent Assay
  • Pharmaceutical Preparations
  • compound 18

• Evidence that Diclofenac and Celecoxib are Thyroid Hormone Receptor Beta Antagonists; use of in silico, Molecular and Pharmacological Techniques

  Perez Diaz, N., Zloh, M., Patel, P. & MacKenzie, L., Dec 2015.

  Research output: Contribution to conference › Abstract

  Open Access

  File

  • Thyroid Hormone Receptors beta
  • Celecoxib
  • Diclofenac
  • Non-Steroidal Anti-Inflammatory Agents
  • Computer Simulation

• Identification of novel compounds that inhibit S100P and RAGE binding as a new therapy for Pancreatic Cancer

  MacKenzie, L., 24 Aug 2015.

  Research output: Contribution to conference › Abstract

  Open Access

  File

  • Receptor for Advanced Glycation End Products
  • Pancreatic Neoplasms
  • Calcium-Binding Proteins
  • Neoplasm Metastasis
  • Neoplasms

• In silico modelling of prostacyclin and other lipid mediators to nuclear receptors reveal novel thyroid hormone receptor antagonist properties

  Perez-Diaz, N., Zloh, M., Patel, P. & Mackenzie, L., 11 Dec 2015, In : Prostaglandins & Other Lipid Mediators. 122, p. 18-27 10 p.

  Research output: Contribution to journal › Article

  • Hormone Antagonists
  • Thyroid Hormone Receptors
  • GW0742
  • Epoprostenol
  • beraprost

• Linking Induction and Transrepression of PPARβ/δ with Cellular Function

  Perez-Diaz, N. & Mackenzie, L., 26 Jan 2015, In : Annual Research and Review in Biology. 6, 4, p. 253-263 11 p.

  Research output: Contribution to journal › Article

  Open Access

  File

  • Peroxisome Proliferator-Activated Receptors
  • Cytoplasmic and Nuclear Receptors
  • Ligands
  • Drug Design
  • Drug Development

• Reply to Letter Regarding Article, "Evidence That Links Loss of Cyclooxygenase-2 With Increased Asymmetric Dimethylarginine: Novel Explanation of Cardiovascular Side Effects Associated With Anti-Inflammatory Drugs

  Ahmetaj-Shala, B., Kirkby, N. S., Knowles, R., Al’Yamani, M., Mazi, S., Wang, Z., Tucker, A. T., Mackenzie, L., Armstrong, P. C. J. & Nusing, R. M., 24 Nov 2015, In : Circulation. 132, 17, p. 213-214 2 p.

  Research output: Contribution to journal › Article

• Targeting PPARbeta/delta in lung disease

  MacKenzie, L., 1 Dec 2015.

  Research output: Contribution to conference › Abstract

• 2014

  Evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine: novel explanation of cardiovascular side effects associated with anti-inflammatory drugs

  Ahmetaj-Shala, B., Kirkby, N. S., Knowles, R., Al’Yamani, M., Mazi, S., Wang, Z., Tucker, A. T., Mackenzie, L., Armstrong, P. C. J. & Nusing, R. M., 9 Dec 2014, In : Circulation. 131, 7, p. 633-642 10 p.

  Research output: Contribution to journal › Article

  Open Access

  File

  • N,N-dimethylarginine
  • Cyclooxygenase 2
  • Anti-Inflammatory Agents
  • omega-N-Methylarginine
  • Kidney

• Role of prostacyclin in pulmonary hypertension

  Mitchell, J., Ahmetaj-Shala, B., Kirkby, N. S., Wright, W. R., Mackenzie, L., Reed, D. M. & Mohamed, N. A., 31 Dec 2014, In : Global Cardiology Science and Practice. 4, p. 382-393 12 p.

  Research output: Contribution to journal › Article

  Open Access

  File

  • Epoprostenol
  • Pulmonary Hypertension
  • Lung
  • Epoprostenol Receptors
  • Hormones

• Selective inhibition of NADPH Oxidase reverses the over contraction of diabetic rat aorta

  Rehman, A. U., Dugic, E., Benham, C. D., Lione, L. A. & Mackenzie, L., 1 Jan 2014, In : Redox Biology. 2, p. 61-64 4 p.

  Research output: Contribution to journal › Article

  Open Access

  File

  • NADPH Oxidases
  • Aorta
  • 3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo(4,5-d)pyrimidine
  • Phenylephrine
  • acetovanillone
• 2013

  Aspirin triggered 15-epi-lipoxin A4 predicts cyclo-oxygenase-2 in the lungs of LPS treated mice but not in the circulation: implications for a clinical test

  Kirkby, N. S., Chan, M., Lundberg, M. H., Massey, K. A., Edmands, W. M. B., Mackenzie, L., Holmes, E., Nicolaou, A., Warner, T. D. & Mitchell, J., 1 Jun 2013, In : Faseb journal. 27, 10, p. 3938-3946 9 p.

  Research output: Contribution to journal › Article

  Open Access

  File

  • aspirin
  • prostaglandin synthase
  • lungs
  • mice
  • testing

• Cross-talk between toll-like receptor 4 (TLR4) and proteinase-activated receptor 2 (PAR) is involved in vascular function

  Bucci, M., Vellecco, V., Harrington, L., Brancaleone, V., Roviezzo, F., Mattace Raso, G., Ianaro, A., Lungarella, G., De Palma, R. & Meli, R., 1 Jan 2013, In : British Journal of Pharmacology. 168, 2, p. 411-420 10 p.

  Research output: Contribution to journal › Article

  • PAR-2 Receptor
  • Toll-Like Receptor 4
  • Blood Vessels
  • Peptides
  • Vasodilation

• Harnessing the benefits of PPARβ/δ agonists

  Mackenzie, L. & Lione, L. A., 18 Dec 2013, In : Life Sciences. 93, 25-26, p. 963-967 5 p.

  Research output: Contribution to journal › Article

  • Peroxisome Proliferator-Activated Receptors
  • Mediator Complex
  • Clinical Trials
  • Lipids
  • Animals

• LC-MS/MS Confirms That COX-1 Drives Vascular Prostacyclin Whilst Gene Expression Pattern Reveals Non-Vascular Sites of COX-2 Expression

  Kirkby, N. S., Zaiss, A. K., Urquhart, P., Jiao, J., Austin, P. J., Al’Yamani, M., Lundberg, M. H., Mackenzie, L., Warner, T. D. & Nicolaou, A., 9 Jul 2013, In : PLoS ONE. 8, 7

  Research output: Contribution to journal › Article

  Open Access

  File

  • Cyclooxygenase 1
  • Epoprostenol
  • Cyclooxygenase 2
  • prostaglandin F1
  • Gene Expression

• Linking phospholipase C isoforms with differentiation function in human vascular smooth muscle cells

  Mackenzie, L., Lymn, J. S. & Hughes, A. D., 14 Aug 2013, In : BBA - Molecular Cell Research. 1833, 12, p. 3006-3012 7 p.

  Research output: Contribution to journal › Article

  Open Access

  File

  • Type C Phospholipases
  • Vascular Smooth Muscle
  • Smooth Muscle Myocytes
  • Protein Isoforms
  • Actins
• 2011

  Reduced endothelial dependent vasodilation in vessels from TLR4 mice is associated with increased superoxide generation

  Harrington, L., Lundberg, M. H., Waight, M., Rozario, A. & Mitchell, J., 20 May 2011, In : Biochemical and biophysical research communications. 408, 4, p. 511-515 5 p.

  Research output: Contribution to journal › Article

  Open Access

  File

  • Superoxides
  • Vasodilation
  • Mesenteric Arteries
  • dihydroethidium
  • Toll-Like Receptor 4

• Role of shear stress in endothelial cell morphology and expression of cyclooxygenase isoforms

  Potter, C. M. F., Lundberg, M. H., Harrington, L., Warboys, C. M., Warner, T. D., Berson, R. E., Moshkov, A. V., Gorelik, J., Weinburg, P. D. & Mitchell, J., 1 Feb 2011, In : Arteriosclerosis Thrombosis and Vascular Biology. 31, 2, p. 384-391 8 p.

  Research output: Contribution to journal › Article

  • Cyclooxygenase 1
  • Prostaglandin-Endoperoxide Synthases
  • Protein Isoforms
  • Cyclooxygenase 2
  • Endothelial Cells