Find Research Outputs

Search concepts
Selected filters

Publication Year

  • 2020
  • 2019
  • 2018
  • 2017
  • 2016
  • 2015
  • 2014
  • 2013
  • 2012
  • 2011

Author

  • David Timson
2020

Galactosemia: opportunities for novel therapies

McCorvie, T. J. & Timson, D. J., 19 Feb 2020, Protein Homeostasis Diseases. Pey, A. L. (ed.). Academic Press, p. 221-245 25 p.

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNChapter

Novel and selective inactivators of Triosephosphate isomerase with anti-trematode activity

Ferraro, F., Corvo, I., Bergalli, L., Ilarraz, A., Cabrera, M., Gil, J., Susuki, B. M., Caffrey, C. R., Timson, D. J., Robert, X., Guillon, C., Freire, T. & Álvarez, G., 13 Feb 2020, In : Scientific Reports. 10, 1, 2587.

Research output: Contribution to journalArticle

Open Access
File

Targeting HIF-1α Function in Cancer through the Chaperone Action of NQO1

Salido, E., Timson, D. J., Betancor-Fernández, I., Palomino-Morales, R. & Pey, A. L., 18 Mar 2020

Research output: Other contribution

Open Access
File

Therapies for galactosemia: a patent landscape

Timson, D. J., 21 Apr 2020, In : Pharmaceutical Patent Analyst.

Research output: Contribution to journalArticle

2019

A Dynamic Core in Human NQO1 Controls the Functional and Stability Effects of Ligand Binding and Their Communication across the Enzyme Dimer

Vankova, P., Salido, E., Timson, D., Man, P. & Pey, A. L., 12 Nov 2019, In : Biomolecules. 9, 11, 728.

Research output: Contribution to journalArticle

Open Access
File

Cancer-associated variants of human NQO1: Impacts on inhibitor binding and cooperativity

Megarity, C. F. & Timson, D. J., 6 Sep 2019, In : Bioscience Reports. 39, 9, BSR20191874.

Research output: Contribution to journalArticle

Open Access
File

Catalytic mechanism of mevalonate kinase revisited, a QM/MM study

McClory, J., Lin, J. T., Timson, D., Zhang, J. & Huang, M., 5 Feb 2019, In : Organic and Biomolecular Chemistry. 17, 9, p. 2423-2431 9 p.

Research output: Contribution to journalArticle

Open Access
File

Characterization of Calcium-Binding Proteins from Parasitic Worms

Thomas, C. M. & Timson, D. J., 2 Feb 2019, Calcium-Binding Proteins of the EF-Hand Superfamily. Heizmann, C. (ed.). New York: Humana Press, Vol. 1929. p. 615-641 27 p. (Methods in molecular biology (Clifton, N.J.)).

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNChapter

Dynamic origins of substrate promiscuity in bacterial galactokinases

McAuley, M., Huang, M. & Timson, D., 17 Oct 2019, In : Carbohydrate Research. 486, 107839.

Research output: Contribution to journalArticle

Evidence for chaotropicity/kosmotropicity offset in a yeast growth model

Eardley, J., Dedi, C., Dymond, M., Hallsworth, J. E. & Timson, D., 26 Sep 2019, In : Biotechnology Letters. 41, 11, p. 1309-1318 10 p.

Research output: Contribution to journalArticle

Four Challenges for Better Biocatalysts

Timson, D. J., 9 May 2019, In : Fermentation. 5, 2, 9 p., 39.

Research output: Contribution to journalArticle

Open Access
File

Fructose 1,6-bisphosphatase: getting the message across

Timson, D., 6 Mar 2019, In : Bioscience Reports. 39, 3, p. 1-5 5 p., BSR20190124.

Research output: Contribution to journalArticle

Open Access
File

Myosin Va and spermine synthase: partners in exosome transport

Timson, D., 30 Apr 2019, In : Bioscience Reports. 39, 4, p. 1-5 5 p., BSR20190326.

Research output: Contribution to journalArticle

Open Access
File

NAD(P)H quinone oxidoreductase (NQO1): An enzyme which needs just enough mobility, in just the right places

Pey, A. L., Megarity, C. F. & Timson, D. J., 3 Jan 2019, In : Bioscience Reports. 39, 1, BSR20180459.

Research output: Contribution to journalArticle

Open Access
File

Negative cooperativity in NAD(P)H quinone oxidoreductase 1 (NQO1)

Megarity, C. F., Abdel-Aal Bettley, H., Caraher, M. C., Scott, K. A., Whitehead, R. A., Jowitt, T. A., Gutierrez, A., Bryce, R. A., Nolan, K. A., Stratford, I. J. & Timson, D. J., 5 Jun 2019, In : ChemBioChem. 20, 22, p. 2841-2849 9 p.

Research output: Contribution to journalArticle

NQO1: A target for the treatment of cancer and neurological diseases, and a model to understand loss of function disease mechanisms

Beaver, S. K., Mesa-Torres, N., Pey, A. L. & Timson, D. J., 12 May 2019, In : BBA - Proteins and Proteomics. 1867, 7-8, p. 663-676 14 p.

Research output: Contribution to journalReview article

Open Access
File

Phosphorylation Mechanism of N-acetyl-L-Glutamate Kinase, a QM/MM Study

McClory, J., Hu, G-X., Zou, J-W., Timson, D. J. & Huang, M., 8 Mar 2019, In : Journal of Physical Chemistry B. 123, 13, p. 2844-2852 9 p.

Research output: Contribution to journalArticle

Open Access
File

Repurposing drugs for the treatment of galactosemia

Timson, D., 22 Oct 2019, In : Expert Opinion on Orphan Drugs. 7, 10, p. 443-451 9 p.

Research output: Contribution to journalReview article

2018

A galactokinase-like protein from the liver fluke Fasciola hepatica

Zinsser, V. L., Cox, C., McAuley, M., Hoey, E. M., Trudgett, A. & Timson, D. J., 21 Jul 2018, In : Experimental Parasitology. 192, p. 65-72 8 p.

Research output: Contribution to journalArticle

Open Access
File
Open Access
File

Improving the activity and stability of human galactokinase for therapeutic and biotechnological applications

McAuley, M., Mesa-Torres, N., McFall, A., Morris, S., Huang, M., Pey, A. L. & Timson, D., 26 Apr 2018, In : ChemBioChem. 19, 10, p. 1088-1095 8 p.

Research output: Contribution to journalArticle

Open Access
File

Modulation of the mobility of a key region in human galactokinase: Impacts on catalysis and stability

McAuley, M., Huang, M. & Timson, D. J., 19 Sep 2018, In : Bioorganic Chemistry. 81, p. 649-657 9 p.

Research output: Contribution to journalArticle

Open Access
File

Natural (and Unnatural) Small Molecules as Pharmacological Chaperones and Inhibitors in Cancer

Betancor-Fernández, I., Timson, D. J., Salido, E. & Pey, A. L., 1 Jan 2018, Targeting Trafficking in Drug Development. Ulloa-Aguirre, A. & Tao, Y. X. (eds.). Springer, p. 155-190 36 p. (Handbook of Experimental Pharmacology; vol. 245).

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNChapter

Prenatal alcohol exposure, biomarkers and fetal alcohol spectrum disorders

Gard, P. R., Zanganeh, M. & Timson, D. J., 4 Dec 2018, Fetal Alcohol Syndrome: Recognition, Differential Diagnosis and Long-Term Effects. Nova Science Publishers Inc, p. 19-57 39 p.

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNChapter

Prenatal Alcohol Exposure, Biomarkers and Foetal Alcohol Spectrum Disorders

Gard, P., Zanganeh, M. & Timson, D., Nov 2018, Fetal Alcohol Syndrome: Recognition, Differential Diagnosis and Long-Term Effects. Knight, D. (ed.). Nova Science Publishers Inc, p. 19-57 38 p.

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNChapter

The mechanism of action of praziquantel: Six hypotheses

Thomas, C. M. & Timson, D. J., 1 Jan 2018, In : Current Topics in Medicinal Chemistry. 18, 18, p. 1575-1584 10 p.

Research output: Contribution to journalReview article

Open Access
File

The mechanism of action of praziquantel: can new drugs exploit similar mechanisms?

Thomas, C. & Timson, D., 26 Sep 2018, In : Current Medicinal Chemistry. 25, 1

Research output: Contribution to journalArticle

Open Access
File

The tegumental allergen-like proteins of Schistosoma mansoni: a biochemical study of SmTAL4-TAL13

Carson, J., Thomas, C. M., McGinty, A., Takata, G. & Timson, D., 14 Feb 2018, In : Molecular and Biochemical Parasitology. 221, p. 14-22 9 p.

Research output: Contribution to journalArticle

Open Access
File

Type IV galactosemia

Timson, D. J., 21 Nov 2018, In : Genetics in Medicine. 21, p. 1283-1285

Research output: Contribution to journalArticle

Open Access
File

Water-mediated network in the resistance mechanism of fosfomycin

McClory, J., Lin, J. T., Timson, D. J., Zhang, J. & Huang, M., 2 Aug 2018, In : Physical Chemistry Chemical Physics. 20, 33, p. 21660-21667 8 p.

Research output: Contribution to journalArticle

Open Access
File
2017

Characterisation of eppin function: expression and activity in the lung

Scott, A., Glasgow, A., Small, D., Carlile, S., McCrudden, M. T. C., McLean, D. T. F., Brown, R., Doherty, D., Lundy, F. T., Hamid, U. I., O'Kane, C. M., McAuley, D. F., Brodlie, M., Tunney, M., Elborn, J. S., Irwin, C. R., Timson, D., Taggart, C. C. & Weldon, S., 13 Jul 2017, In : European Respiratory Journal. 50, 1

Research output: Contribution to journalArticle

Open Access
File

Different specificities of two aldehyde dehydrogenases from Saccharomyces cerevisiae var boulardii

Datta, S., Annapore, U. S. & Timson, D., 26 Jan 2017, In : Bioscience Reports. 37, 2

Research output: Contribution to journalArticle

Open Access
File

Enhanced vulnerability of human proteins towards disease-associated inactivation through divergent evolution

Medina-Carmona, E., Fuchs, J. E., Gavira, J. A., Mesa-Torres, N., Neira, J. L., Salido, E., Palomino-Morales, R. J., Burgos, M., Timson, D. & Pey, A. L., 6 Jul 2017, In : Human Molecular Genetics. 26, 18, p. 3531-3544 14 p.

Research output: Contribution to journalArticle

Open Access
File
Open Access
File

LGR5 receptor promotes cell-cell adhesion in stem cells and colon cancer cells via the IQGAP1 -Rac1 pathway

Carmon, K. S., Xing, G., Yi, J., Wu, L., Thomas, A., Moore, C., Masuho, I., Timson, D., Martemyanov, K. A. & Liu, Q. J., 24 Jul 2017, In : Journal of Biological Chemistry. 292, p. 14989-15001 13 p.

Research output: Contribution to journalArticle

Open Access
File

Molecular Genetics of Galactosaemia

Timson, D., 15 May 2017, eLS. Chichester: John Wiley & Sons Ltd

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNChapter

New model for the interaction of IQGAP1 with CDC42 and RAC1

Nouri, K., Timson, D. & Ahmadian, M. R., 19 Jun 2017, In : Small GTPases.

Research output: Contribution to journalArticle

Open Access
File

Reaction Mechanism of Isopentenyl Phosphate Kinase: A QM/MM Study

McClory, J., Timson, D., Singh, W., Zhang, J. & Huang, M., 20 Nov 2017, In : Journal of Physical Chemistry B. 121, 49, p. 11062-11071 10 p.

Research output: Contribution to journalArticle

Open Access
File

Site-to-site interdomain communication may mediate different loss-of-function mechanisms in a cancer-associated NQO1 polymorphism

Medina-Carmona, E., Neira, J. L., Salido, E., Fuchs, J. E., Palomino-Morales, R. J., Timson, D. & Pey, A. L., 14 Mar 2017, In : Scientific Reports. 7

Research output: Contribution to journalArticle

Open Access
File
Open Access
File

We are all mutants

Timson, D., 2017, In : School Science Review. 99, 366, p. 45-50

Research output: Contribution to journalArticle

2016

A mysterious family of calcium-binding proteins from parasitic worms

Thomas, C. M. & Timson, D. J., 15 Aug 2016, In : Biochemical Society Transactions. 44, 4, p. 1005-1010 6 p.

Research output: Contribution to journalArticle

Open Access
File

Antioxidant properties and global metabolite screening ofthe probiotic yeast Saccharomyces cerevisiae var. boulardii

Datta, S., Timson, D. & Annapure, U. S., 21 Nov 2016, In : Journal of the Science of Food and Agriculture. 97, 9, p. 3039-3049 11 p.

Research output: Contribution to journalArticle

Open Access
File

Calmodulin disruption impacts growth and motility in juvenile liver fluke

Timson, D., 27 Jan 2016, In : Parasites & Vectors. 9, p. 1-13 13 p.

Research output: Contribution to journalArticle

Open Access
File

Characterization of Cd36_03230p, a putative vanillin dehydrogenase from Candida dubliniensis

Datta, S., Annapure, U. S. & Timson, D., 14 Oct 2016, In : RSC Advances. 6, 102, p. 99774-99780 7 p.

Research output: Contribution to journalArticle

Open Access
File

Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands

Medina-Carmona, E., Palomino-Morales, R. J., Fuchs, J. E., Padin-Gonzalez, E., Mesa-Torres, N., Salido, E., Timson, D. & Pey, A. L., 3 Feb 2016, In : Scientific Reports. 6

Research output: Contribution to journalArticle

Open Access
File

Disturbed cofactor binding by a novel mutation in UDP-galactose 4 '-epimerase results in a type III galactosemia phenotype at birth

Paul, S., McCorvie, T. J., Zschocke, J. & Timson, D., 3 Feb 2016, In : RSC Advances. 6, 21, p. 17297-17301 5 p.

Research output: Contribution to journalArticle

Open Access
File

Experimental and computational evidence on conformational fluctuations as a source of catalytic defects in genetic diseases

Fuchs, J. E., Munoz, I. G., Timson, D. & Pey, A. L., 13 Jun 2016, In : RSC Advances. 6, 63, p. 58604-58612 9 p.

Research output: Contribution to journalArticle

Open Access
File