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  • Louise MacKenzie
2019

Off-target interactions as novel explantion of NSAID CV risk

Dolan, G., MacKenzie, L., Zloh, M. & Lione, L., Apr 2019.

Research output: Contribution to conferenceAbstract

Open Access
File

Regulation of pulmonary artery inflamation by PPARβ/δ

Perez Diaz, N., Lione, L., MacKenzie, L. & Hutter, V., Apr 2019.

Research output: Contribution to conferenceAbstract

Open Access
File
2018

An overview of anti-diabetic plants used in Gabon: Pharmacology and toxicology

Bading Taika, B., Bouckandou, M., Souza, A., Bourobou Bourobou, H. P., Mackenzie, L. & Lione, L. A., 2 Jan 2018, In : Journal of Ethnopharmacology. 216, p. 203-228 26 p.

Research output: Contribution to journalArticle

Open Access
File

Predicted interactions of selected NSAIDS with hERG potassium channel using Virtual Toxlab

Dolan, G., MacKenzie, L., Zloh, M. & Lione, L., Mar 2018.

Research output: Contribution to conferenceAbstract

Open Access
File

The non-genomic effects of the PPARβ/δ agonist GW0742 on STZ treated rat aorta

Perez-Diaz, N., Pushkarsky, I., Oweis, N., Lione, L. A. & Mackenzie, L., 31 Dec 2018, In : Current Molecular Pharmacology. 11, 2, p. 149-154 6 p.

Research output: Contribution to journalArticle

2017

Exploration of the structural differences between safe and unsafe NSAIDs using 3D molecular similarity

Dolan, G., MacKenzie, L. & Zloh, M., Dec 2017.

Research output: Contribution to conferenceAbstract

Open Access
File

Identifying compounds that inhibit S100P – RAGE binding as a novel therapy for pancreatic cancer

Ogbeni, D., Camara, R., Chau, D., Patel, P., Kirton, S., MacKenzie, L. & Rossiter, S., 5 Jul 2017.

Research output: Contribution to conferenceAbstract

Open Access
File

Identifying inhibitor of S100P – RAGE binding as a novel therapy for pancreatic cancer

Ogbeni, D., Camara, R., Kirton, S., Patel, P., Crnogorac-Jurcevic, T., MacKenzie, L., Chau, D. & Rossiter, S., 5 Sep 2017.

Research output: Contribution to conferenceAbstract

Open Access
File

New Drugs for Pancreatic Cancer

Ogbeni, D., Chau, D., Patel, P., Rossiter, S. & MacKenzie, L., 13 Mar 2017.

Research output: Contribution to conferenceAbstract

Open Access
File

Novel compounds for the inhibition of S100P binding with RAGE as a potential therapy for pancreatic cancer

Ogbeni, D., Camara, R., Kirton, S., Crnogorac-Jurcevic, T., MacKenzie, L., Chau, D. & Rossiter, S., 5 Jul 2017.

Research output: Contribution to conferenceAbstract

Open Access
File

This new treatment could make pancreatic cancer a manageable disease

Ogbeni, D. & MacKenzie, L., 9 Feb 2017, The Conversation.

Research output: Other contribution

Open Access

Thyroid Hormone Receptor Antagonists; from Environmental Pollution to Novel Small Molecules

Mackenzie, L., 5 Jun 2017, Vitamins and Hormones. Litwack, G. (ed.). UK: Elsevier, Vol. 106. p. 147-162 16 p. (Vitamins and Hormones).

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNChapter

2016

A New NO-Releasing Nanoformulation for the Treatment of Pulmonary Arterial Hypertension

Mohamed, N. A., Ahmetaj-Shala, B., Duluc, L., Mackenzie, L., Kirkby, N. S., Reed, D. M., Lickiss, P. D., Davies, R. P., Freeman, G. & Wojciak-Stothard, B., 9 Mar 2016, In : Journal of Cardiovascular Translational Research. 9, 2, p. 162-164 3 p.

Research output: Contribution to journalArticle

Open Access
File

Can NSAIDs alter thyroid hormone function?

MacKenzie, L., 26 Apr 2016, The Atlas of Science .

Research output: Other contribution

Open Access

Can NSAIDs alter Thyroid Hormone Function?

MacKenzie, L., 28 Sep 2016.

Research output: Contribution to conferenceAbstract

Evidence that Diclofenac and Celecoxib are thyroid hormone receptor beta antagonists

Zloh, M., Perez-Diaz, N., Tang, L., Patel, P. & Mackenzie, L., 1 Feb 2016, In : Life Sciences. 146, p. 66-72 7 p.

Research output: Contribution to journalArticle

Methylglyoxal, A Metabolite Increased in Diabetes is Associated with InsulinResistance, Vascular Dysfunction and Neuropathies

Shamsaldeen, Y. A., Mackenzie, L., Lione, L. A. & Benham, C. D., 1 Jan 2016, In : Current Drug Metabolism. 17, 4, p. 359-367 9 p.

Research output: Contribution to journalArticle

Open Access
File
2015

ELISA screen of novel compounds that inhibit S100P and RAGE binding to identify new candidate drugs as a new therapy for pancreatic cancer

Ogbeni, D., Camara, R., Chau, D., Kirton, S., Rossiter, S. & MacKenzie, L., 2015.

Research output: Contribution to conferenceAbstract

Open Access
File

Evidence that Diclofenac and Celecoxib are Thyroid Hormone Receptor Beta Antagonists; use of in silico, Molecular and Pharmacological Techniques

Perez Diaz, N., Zloh, M., Patel, P. & MacKenzie, L., Dec 2015.

Research output: Contribution to conferenceAbstract

Open Access
File
Open Access
File

In silico modelling of prostacyclin and other lipid mediators to nuclear receptors reveal novel thyroid hormone receptor antagonist properties

Perez-Diaz, N., Zloh, M., Patel, P. & Mackenzie, L., 11 Dec 2015, In : Prostaglandins & Other Lipid Mediators. 122, p. 18-27 10 p.

Research output: Contribution to journalArticle

Linking Induction and Transrepression of PPARβ/δ with Cellular Function

Perez-Diaz, N. & Mackenzie, L., 26 Jan 2015, In : Annual Research and Review in Biology. 6, 4, p. 253-263 11 p.

Research output: Contribution to journalArticle

Open Access
File

Reply to Letter Regarding Article, "Evidence That Links Loss of Cyclooxygenase-2 With Increased Asymmetric Dimethylarginine: Novel Explanation of Cardiovascular Side Effects Associated With Anti-Inflammatory Drugs

Ahmetaj-Shala, B., Kirkby, N. S., Knowles, R., Al’Yamani, M., Mazi, S., Wang, Z., Tucker, A. T., Mackenzie, L., Armstrong, P. C. J. & Nusing, R. M., 24 Nov 2015, In : Circulation. 132, 17, p. 213-214 2 p.

Research output: Contribution to journalArticle

Targeting PPARbeta/delta in lung disease

MacKenzie, L., 1 Dec 2015.

Research output: Contribution to conferenceAbstract

2014

Evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine: novel explanation of cardiovascular side effects associated with anti-inflammatory drugs

Ahmetaj-Shala, B., Kirkby, N. S., Knowles, R., Al’Yamani, M., Mazi, S., Wang, Z., Tucker, A. T., Mackenzie, L., Armstrong, P. C. J. & Nusing, R. M., 9 Dec 2014, In : Circulation. 131, 7, p. 633-642 10 p.

Research output: Contribution to journalArticle

Open Access
File

Role of prostacyclin in pulmonary hypertension

Mitchell, J., Ahmetaj-Shala, B., Kirkby, N. S., Wright, W. R., Mackenzie, L., Reed, D. M. & Mohamed, N. A., 31 Dec 2014, In : Global Cardiology Science and Practice. 4, p. 382-393 12 p.

Research output: Contribution to journalArticle

Open Access
File

Selective inhibition of NADPH Oxidase reverses the over contraction of diabetic rat aorta

Rehman, A. U., Dugic, E., Benham, C. D., Lione, L. A. & Mackenzie, L., 1 Jan 2014, In : Redox Biology. 2, p. 61-64 4 p.

Research output: Contribution to journalArticle

Open Access
File
2013

Aspirin triggered 15-epi-lipoxin A4 predicts cyclo-oxygenase-2 in the lungs of LPS treated mice but not in the circulation: implications for a clinical test

Kirkby, N. S., Chan, M., Lundberg, M. H., Massey, K. A., Edmands, W. M. B., Mackenzie, L., Holmes, E., Nicolaou, A., Warner, T. D. & Mitchell, J., 1 Jun 2013, In : Faseb journal. 27, 10, p. 3938-3946 9 p.

Research output: Contribution to journalArticle

Open Access
File

Cross-talk between toll-like receptor 4 (TLR4) and proteinase-activated receptor 2 (PAR) is involved in vascular function

Bucci, M., Vellecco, V., Harrington, L., Brancaleone, V., Roviezzo, F., Mattace Raso, G., Ianaro, A., Lungarella, G., De Palma, R. & Meli, R., 1 Jan 2013, In : British Journal of Pharmacology. 168, 2, p. 411-420 10 p.

Research output: Contribution to journalArticle

Harnessing the benefits of PPARβ/δ agonists

Mackenzie, L. & Lione, L. A., 18 Dec 2013, In : Life Sciences. 93, 25-26, p. 963-967 5 p.

Research output: Contribution to journalArticle

LC-MS/MS Confirms That COX-1 Drives Vascular Prostacyclin Whilst Gene Expression Pattern Reveals Non-Vascular Sites of COX-2 Expression

Kirkby, N. S., Zaiss, A. K., Urquhart, P., Jiao, J., Austin, P. J., Al’Yamani, M., Lundberg, M. H., Mackenzie, L., Warner, T. D. & Nicolaou, A., 9 Jul 2013, In : PLoS ONE. 8, 7

Research output: Contribution to journalArticle

Open Access
File

Linking phospholipase C isoforms with differentiation function in human vascular smooth muscle cells

Mackenzie, L., Lymn, J. S. & Hughes, A. D., 14 Aug 2013, In : BBA - Molecular Cell Research. 1833, 12, p. 3006-3012 7 p.

Research output: Contribution to journalArticle

Open Access
File
2012

Cyclooxygenase-1, not cyclooxygenase-2, is responsible for physiological production of prostacyclin in the cardiovascular system

Kirkby, N. S., Lundberg, M. H., Harrington, L., Leadbeater, P. D. M., Milne, G., Potter, C. M. F., Al’Yamani, M., Adeyemi, O., Warner, T. D. & Mitchell, J., 23 Oct 2012, In : Proceedings of the National Academy of Sciences. 109, 43, p. 17597-17602 6 p.

Research output: Contribution to journalArticle

Role of RhoB in the regulation of pulmonary endothelial and smooth muscle cell responses to hypoxia

Wojciak-Stothard, B., Zhao, L., Oliver, E., Dubois, O., Wu, Y., Kardassis, D., Vasilaki, E., Huang, M., Mitchell, J. & Harrington, L., 25 May 2012, In : Circulation Research. 110, 11, p. 1423-1434 12 p.

Research output: Contribution to journalArticle

2011

Reduced endothelial dependent vasodilation in vessels from TLR4 mice is associated with increased superoxide generation

Harrington, L., Lundberg, M. H., Waight, M., Rozario, A. & Mitchell, J., 20 May 2011, In : Biochemical and biophysical research communications. 408, 4, p. 511-515 5 p.

Research output: Contribution to journalArticle

Open Access
File

Role of shear stress in endothelial cell morphology and expression of cyclooxygenase isoforms

Potter, C. M. F., Lundberg, M. H., Harrington, L., Warboys, C. M., Warner, T. D., Berson, R. E., Moshkov, A. V., Gorelik, J., Weinburg, P. D. & Mitchell, J., 1 Feb 2011, In : Arteriosclerosis Thrombosis and Vascular Biology. 31, 2, p. 384-391 8 p.

Research output: Contribution to journalArticle