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2016

IQGAP1 interaction with RHO family proteins revisited: Kinetic andequilibrium evidence for multiple distinct binding sites

Nouri, K., Fansa, E. K., Amin, E., Dvorsky, R., Gremer, L., Willbold, D., Schmitt, L., Timson, D. & Ahmadian, M. R., 4 Nov 2016, In : Journal of Biological Chemistry. 291, 0, p. 26364-26376 13 p.

Research output: Contribution to journalArticle

Open Access
File
GTP Phosphohydrolases
Binding Sites
Proteins
Cell Polarity
Guanosine Triphosphate

Metabolic Enzymes of Helminth Parasites: Potential as Drug Targets

Timson, D., 31 Dec 2016, In : Current Protein & Peptide Science. 17, 3, p. 280-295 16 p.

Research output: Contribution to journalArticle

Open Access
File

Modulating mobility: a paradigm for protein engineering?

McAuley, M. & Timson, D., 23 Jul 2016, In : Applied Biochemistry and Biotechnology. p. 1-8 8 p.

Research output: Contribution to journalArticle

Open Access
File
Proteins
Ligands
Catalysis
Molecular dynamics
Engineers

Natural small molecules as stabilizers and activators of cancer-associated NQO1 polymorphisms

Pey, A. L., Megarity, C. F., Medina-Carmona, E. & Timson, D., 1 Jan 2016, In : Current Drug Targets. 17, 13, p. 1506-1514 9 p.

Research output: Contribution to journalArticle

Open Access
File
Neoplasms
Pharmacology
Quinones
Protein Stability
NAD

On the Interaction Between Human IQGAP1 and Actin

Magill, D. J., Hamilton, E., Shirran, S. L., Botting, C. H. & Timson, D., 1 Apr 2016, In : Protein and Peptide Letters. 23, 4, p. 386-395 10 p.

Research output: Contribution to journalArticle

Open Access
File
Actins
Proteins
Static Electricity
Cold Climate
Saccharomyces cerevisiae Proteins

Phosphorylation Mechanism of Phosphomevalonate Kinase: Implications for Rational Engineering of Isoprenoid Biosynthetic Pathway Enzymes

Huang, M., Wei, K., Li, X., McClory, J., Hu, G., Zou, J-W. & Timson, D., 27 Sep 2016, In : Journal of Physical Chemistry B. 120, 41, p. 10714-10722 9 p.

Research output: Contribution to journalArticle

Open Access
File
Phosphorylation
Terpenes
Mevalonic Acid
Phosphotransferases
Enzymes
2015

Chaotropicity: a key factor in product tolerance of biofuel-producing microorganisms

Cray, J. A., Stevenson, A., Ball, P., Bankar, S. B., Eleutherio, E. C. A., Ezeji, T. C., Singhal, R. S., Thevelein, J. M., Timson, D. & Hallsworth, J. E., 30 Jun 2015, In : Current Opinion in Biotechnology. 33, p. 228-259 32 p.

Research output: Contribution to journalArticle

Comparative biochemical analysis of three members of the Schistosoma mansoni TAL family: Differences in ion and drug binding properties

Thomas, C. M., Fitzsimmons, C. M., Timson, D. & Dunne, D. W., 31 Jan 2015, In : Biochimie. 108, p. 40-47 8 p.

Research output: Contribution to journalArticle

Open Access
File

Dicoumarol: a drug which hits at least two very different targets in vitamin K metabolism

Timson, D., 22 Jul 2015, In : Current Drug Targets. 16, p. 1-11 11 p.

Research output: Contribution to journalArticle

Open Access
File
Dicumarol
Vitamin K
Warfarin
Vitamin K Epoxide Reductases
Pharmaceutical Preparations

FhCaBP2: a Fasciola hepatica calcium-binding protein with EF-hand and dynein light chain domains

Thomas, C. M. & Timson, D., 30 Sep 2015, In : Parasitology. 142, 11, p. 1375-1386 12 p.

Research output: Contribution to journalArticle

Open Access
File

Is there a common water-activity limit for the three domains of life?

Stevenson, A., Cray, J. A., Williams, J. P., Santos, R., Sahay, R., Neuenkirchen, N., McClure, C. D., Grant, I. R., Houghton, J. D. R. & Timson, D., 30 Jun 2015, In : ISME Journal. 9, 6, p. 1333-1351 19 p.

Research output: Contribution to journalArticle

Open Access
File

Multiplication of microbes below 0.690 water activity: implications for terrestrial and extraterrestrial life

Stevenson, A., Burkhardt, J., Cockell, C. S., Cray, J. A., Dijksterhuis, J., Fox-Powell, M., Kee, T. P., Kminek, G., McGenity, T. J. & Timson, D., 28 Feb 2015, In : Environmental Microbiology. 17, 2, p. 257-277 21 p.

Research output: Contribution to journalArticle

Quantitative enzymology

Timson, D. J., 1 Jul 2015, In : Current Enzyme Inhibition. 11, 1, p. 12-31 20 p.

Research output: Contribution to journalArticle

Enzymes
Enzyme kinetics
Biotechnology
Drug Delivery Systems
Therapeutics

The molecular basis of galactosemia — Past, present and future

Timson, D. J., 2 Jul 2015, In : Gene. 589, 2, p. 133-141 9 p.

Research output: Contribution to journalArticle

Galactosemias
Galactose
UDPglucose 4-Epimerase
Oxidative Stress
Inborn Errors Metabolism

UDP-galactose 4 '-epimerase from the liver fluke, Fasciola hepatica: biochemical characterization of the enzyme and identification of inhibitors

Zinsser, V. L., Lindert, S., Banford, S., Hoey, E. M., Trudgett, A. & Timson, D., 31 Mar 2015, In : Parasitology. 142, 3, p. 463-472 10 p.

Research output: Contribution to journalArticle

2014

Biochemical characterisation of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) from the liver fluke, Fasciola hepatica

Zinsser, V. L., Hoey, E. M., Trudgett, A. & Timson, D., 30 Apr 2014, In : BBA - Proteins and Proteomics. 1844, 4, p. 744-749 6 p.

Research output: Contribution to journalArticle

Calcium binding proteins in the liver fluke, Fasciola Hepatica

Russell, S. L. & Timson, D. J., 1 Jan 2014, New Developments in Calcium Signaling Research. Nova Science Publishers Inc, p. 89-103 15 p.

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNChapter

Fasciola hepatica
Calcium-Binding Proteins
Liver
Calcium
Dyneins

Cause or effect: which genetic changes are associated with cancer?

Timson, D., 2014, In : Gene, Cell and Tissue. 1, 3, e23818.

Research output: Contribution to journalArticle

Open Access
File

FAD binding overcomes defects in activity and stability displayed by cancer-associated variants of human NQO1

Pey, A. L., Megarity, C. F. & Timson, D., 30 Nov 2014, In : BBA - Molecular Basis of Disease. 1842, 11, p. 2163-2173 11 p.

Research output: Contribution to journalArticle

Purple sweet potato colour - a potential therapy for galactosemia?

Timson, D., 30 Jun 2014, In : International Journal Of Food Sciences And Nutrition. 65, 4, p. 391-393 3 p.

Research output: Contribution to journalArticle

The Saccharomyces cerevisiae quinone oxidoreductase Lot6p: stability, inhibition and cooperativity

Megarity, C. F., Looi, H. K. & Timson, D., 31 Aug 2014, In : Fems Yeast Research. 14, 5, p. 797-807 11 p.

Research output: Contribution to journalArticle

The two common polymorphic forms of human NRH-quinone oxidoreductase 2 (NQO2) have different biochemical properties

Timson, D., Megarity, C. F., Gill, J. R. E., Caraher, C. M., Stratford, I. J. & Nolan, K. A., 2 May 2014, In : Febs Letters. 588, 9, p. 1666-1672 7 p.

Research output: Contribution to journalArticle

Open Access
File

UDP-galactose-4-epimerase (GALE)

McCorvie, T. J. & Timson, D. J., 5 Feb 2014, Handbook of Glycosyltransferases and Related Genes, Second Edition. Springer Japan, Vol. 2. p. 1449-1464 16 p.

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNChapter

UDPglucose 4-Epimerase
Uridine Diphosphate
Monosaccharides
Enzymes
Galactose
2012

Biochemical analysis of the interactions of IQGAP1 C-terminal domain with CDC42

Elliott, S. F., Allen, G. & Timson, D., 26 Mar 2012, In : World Journal of Biological Chemistry. 3, 3, p. 53-60

Research output: Contribution to journalArticle

Open Access
File
Proteins
Neoplasms
Mutation
Ethyldimethylaminopropyl Carbodiimide
Phosphorylation

Fructose chemistry

Timson, D., 2012, Dietary Sugars: Chemistry, Analysis, Function and Effects. Royal Society of Chemistry, p. 115-137

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNChapter

Fructose
fructokinase
Molecules
Ketoses
Glucose

Galactokinases: Potential Biotechnological Applications as Biocatalysts

Kristiansson, H. & Timson, D., 2012, In : Current Biotechnology. 1, 2, p. 148-154 7 p.

Research output: Contribution to journalArticle

Enzymes
Galactokinase
Galactose
Phosphotransferases
homoserine kinase
2010

A ligand predication tool based on modeling and reasoning with imprecise probabilistic knowledge

Liu, W., Yue, A. & Timson, D., 30 Apr 2010, In : Computer Methods and Programs in Biomedicine. 98, 1, p. 45-54 10 p.

Research output: Contribution to journalArticle

Yeasts
Proteins
Saccharomyces cerevisiae
Saccharomycetales
Fungal Proteins