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2010

A ligand predication tool based on modeling and reasoning with imprecise probabilistic knowledge

Liu, W., Yue, A. & Timson, D., 30 Apr 2010, In : Computer Methods and Programs in Biomedicine. 98, 1, p. 45-54 10 p.

Research output: Contribution to journalArticle

Yeasts
Proteins
Saccharomyces cerevisiae
Saccharomycetales
Fungal Proteins
2012

Biochemical analysis of the interactions of IQGAP1 C-terminal domain with CDC42

Elliott, S. F., Allen, G. & Timson, D., 26 Mar 2012, In : World Journal of Biological Chemistry. 3, 3, p. 53-60

Research output: Contribution to journalArticle

Open Access
File
Proteins
Neoplasms
Mutation
Ethyldimethylaminopropyl Carbodiimide
Phosphorylation

Fructose chemistry

Timson, D., 2012, Dietary Sugars: Chemistry, Analysis, Function and Effects. Royal Society of Chemistry, p. 115-137

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNChapter

Fructose
fructokinase
Molecules
Ketoses
Glucose

Galactokinases: Potential Biotechnological Applications as Biocatalysts

Kristiansson, H. & Timson, D., 2012, In : Current Biotechnology. 1, 2, p. 148-154 7 p.

Research output: Contribution to journalArticle

Enzymes
Galactokinase
Galactose
Phosphotransferases
homoserine kinase
2014

Biochemical characterisation of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) from the liver fluke, Fasciola hepatica

Zinsser, V. L., Hoey, E. M., Trudgett, A. & Timson, D., 30 Apr 2014, In : BBA - Proteins and Proteomics. 1844, 4, p. 744-749 6 p.

Research output: Contribution to journalArticle

Calcium binding proteins in the liver fluke, Fasciola Hepatica

Russell, S. L. & Timson, D. J., 1 Jan 2014, New Developments in Calcium Signaling Research. Nova Science Publishers Inc, p. 89-103 15 p.

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNChapter

Fasciola hepatica
Calcium-Binding Proteins
Liver
Calcium
Dyneins

Cause or effect: which genetic changes are associated with cancer?

Timson, D., 2014, In : Gene, Cell and Tissue. 1, 3, e23818.

Research output: Contribution to journalArticle

Open Access
File

FAD binding overcomes defects in activity and stability displayed by cancer-associated variants of human NQO1

Pey, A. L., Megarity, C. F. & Timson, D., 30 Nov 2014, In : BBA - Molecular Basis of Disease. 1842, 11, p. 2163-2173 11 p.

Research output: Contribution to journalArticle

Purple sweet potato colour - a potential therapy for galactosemia?

Timson, D., 30 Jun 2014, In : International Journal Of Food Sciences And Nutrition. 65, 4, p. 391-393 3 p.

Research output: Contribution to journalArticle

The Saccharomyces cerevisiae quinone oxidoreductase Lot6p: stability, inhibition and cooperativity

Megarity, C. F., Looi, H. K. & Timson, D., 31 Aug 2014, In : Fems Yeast Research. 14, 5, p. 797-807 11 p.

Research output: Contribution to journalArticle

The two common polymorphic forms of human NRH-quinone oxidoreductase 2 (NQO2) have different biochemical properties

Timson, D., Megarity, C. F., Gill, J. R. E., Caraher, C. M., Stratford, I. J. & Nolan, K. A., 2 May 2014, In : Febs Letters. 588, 9, p. 1666-1672 7 p.

Research output: Contribution to journalArticle

Open Access
File

UDP-galactose-4-epimerase (GALE)

McCorvie, T. J. & Timson, D. J., 5 Feb 2014, Handbook of Glycosyltransferases and Related Genes, Second Edition. Springer Japan, Vol. 2. p. 1449-1464 16 p.

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNChapter

UDPglucose 4-Epimerase
Uridine Diphosphate
Monosaccharides
Enzymes
Galactose
2015

Chaotropicity: a key factor in product tolerance of biofuel-producing microorganisms

Cray, J. A., Stevenson, A., Ball, P., Bankar, S. B., Eleutherio, E. C. A., Ezeji, T. C., Singhal, R. S., Thevelein, J. M., Timson, D. & Hallsworth, J. E., 30 Jun 2015, In : Current Opinion in Biotechnology. 33, p. 228-259 32 p.

Research output: Contribution to journalArticle

Comparative biochemical analysis of three members of the Schistosoma mansoni TAL family: Differences in ion and drug binding properties

Thomas, C. M., Fitzsimmons, C. M., Timson, D. & Dunne, D. W., 31 Jan 2015, In : Biochimie. 108, p. 40-47 8 p.

Research output: Contribution to journalArticle

Open Access
File

Dicoumarol: a drug which hits at least two very different targets in vitamin K metabolism

Timson, D., 22 Jul 2015, In : Current Drug Targets. 16, p. 1-11 11 p.

Research output: Contribution to journalArticle

Open Access
File
Dicumarol
Vitamin K
Warfarin
Vitamin K Epoxide Reductases
Pharmaceutical Preparations

FhCaBP2: a Fasciola hepatica calcium-binding protein with EF-hand and dynein light chain domains

Thomas, C. M. & Timson, D., 30 Sep 2015, In : Parasitology. 142, 11, p. 1375-1386 12 p.

Research output: Contribution to journalArticle

Open Access
File

Is there a common water-activity limit for the three domains of life?

Stevenson, A., Cray, J. A., Williams, J. P., Santos, R., Sahay, R., Neuenkirchen, N., McClure, C. D., Grant, I. R., Houghton, J. D. R. & Timson, D., 30 Jun 2015, In : ISME Journal. 9, 6, p. 1333-1351 19 p.

Research output: Contribution to journalArticle

Open Access
File

Multiplication of microbes below 0.690 water activity: implications for terrestrial and extraterrestrial life

Stevenson, A., Burkhardt, J., Cockell, C. S., Cray, J. A., Dijksterhuis, J., Fox-Powell, M., Kee, T. P., Kminek, G., McGenity, T. J. & Timson, D., 28 Feb 2015, In : Environmental Microbiology. 17, 2, p. 257-277 21 p.

Research output: Contribution to journalArticle

Quantitative enzymology

Timson, D. J., 1 Jul 2015, In : Current Enzyme Inhibition. 11, 1, p. 12-31 20 p.

Research output: Contribution to journalArticle

Enzymes
Enzyme kinetics
Biotechnology
Drug Delivery Systems
Therapeutics

The molecular basis of galactosemia — Past, present and future

Timson, D. J., 2 Jul 2015, In : Gene. 589, 2, p. 133-141 9 p.

Research output: Contribution to journalArticle

Galactosemias
Galactose
UDPglucose 4-Epimerase
Oxidative Stress
Inborn Errors Metabolism

UDP-galactose 4 '-epimerase from the liver fluke, Fasciola hepatica: biochemical characterization of the enzyme and identification of inhibitors

Zinsser, V. L., Lindert, S., Banford, S., Hoey, E. M., Trudgett, A. & Timson, D., 31 Mar 2015, In : Parasitology. 142, 3, p. 463-472 10 p.

Research output: Contribution to journalArticle

2016

A mysterious family of calcium-binding proteins from parasitic worms

Thomas, C. M. & Timson, D. J., 15 Aug 2016, In : Biochemical Society Transactions. 44, 4, p. 1005-1010 6 p.

Research output: Contribution to journalArticle

Open Access
File
Calcium-Binding Proteins
Helminths
Ions
Calcium
EF Hand Motifs

Antioxidant properties and global metabolite screening ofthe probiotic yeast Saccharomyces cerevisiae var. boulardii

Datta, S., Timson, D. & Annapure, U. S., 21 Nov 2016, In : Journal of the Science of Food and Agriculture. 97, 9, p. 3039-3049 11 p.

Research output: Contribution to journalArticle

Open Access
File
probiotics
Saccharomyces cerevisiae
metabolites
yeasts
screening

Calmodulin disruption impacts growth and motility in juvenile liver fluke

Timson, D., 27 Jan 2016, In : Parasites & Vectors. 9, p. 1-13 13 p.

Research output: Contribution to journalArticle

Open Access
File
Fasciola hepatica
Calmodulin
Growth
Calcium
Fasciola

Characterization of Cd36_03230p, a putative vanillin dehydrogenase from Candida dubliniensis

Datta, S., Annapure, U. S. & Timson, D., 14 Oct 2016, In : RSC Advances. 6, 102, p. 99774-99780 7 p.

Research output: Contribution to journalArticle

Open Access
File
Candida
Aldehyde Dehydrogenase
Substrates
Yeast
CD36 Antigens

Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands

Medina-Carmona, E., Palomino-Morales, R. J., Fuchs, J. E., Padin-Gonzalez, E., Mesa-Torres, N., Salido, E., Timson, D. & Pey, A. L., 3 Feb 2016, In : Scientific Reports. 6

Research output: Contribution to journalArticle

Open Access
File
Flavin-Adenine Dinucleotide
Pharmacology
Ligands
Neoplasms
Dicumarol

Disturbed cofactor binding by a novel mutation in UDP-galactose 4 '-epimerase results in a type III galactosemia phenotype at birth

Paul, S., McCorvie, T. J., Zschocke, J. & Timson, D., 3 Feb 2016, In : RSC Advances. 6, 21, p. 17297-17301 5 p.

Research output: Contribution to journalArticle

Open Access
File
UDPglucose 4-Epimerase
Galactosemias
Galactose
Parturition
Phenotype

Experimental and computational evidence on conformational fluctuations as a source of catalytic defects in genetic diseases

Fuchs, J. E., Munoz, I. G., Timson, D. & Pey, A. L., 13 Jun 2016, In : RSC Advances. 6, 63, p. 58604-58612 9 p.

Research output: Contribution to journalArticle

Open Access
File
NAD
Defects
Molecular dynamics
UDPglucose 4-Epimerase
Thermodynamics

Fasciola hepaticacalcium binding protein FhCaBP2: Structure of the dynein light chain-like domain

Nguyen, T. H., Thomas, C. M., Timson, D. & Van Raaij, M. J., 16 Apr 2016, In : Parasitology Research. 115, 7, p. 2879-2886 8 p.

Research output: Contribution to journalArticle

Open Access
File
Fasciola
Dyneins
Fasciola hepatica
Carrier Proteins
EF Hand Motifs

FhCaBP1 (FH22): a Fasciola hepatica calcium-binding protein with EF-hand and dynein light chain domains

Thomas, C. M., Cheung, S. & Timson, D., 28 Sep 2016, In : Experimental Parasitology. 170, p. 109-115 7 p.

Research output: Contribution to journalArticle

Open Access
File
Dyneins
Calcium-Binding Proteins
Ions
Calcium
Proteins

Galactokinase promiscuity: A question of flexibility?

McAuley, M., Kristiansson, H., Huang, M., Pey, A. L. & Timson, D. J., 9 Feb 2016, In : Biochemical Society Transactions. 44, p. 116-122 7 p.

Research output: Contribution to journalArticle

Open Access
File
Galactokinase
Galactosemias
Sugars
Catalytic Domain
Enzymes

Glycerol enhances fungal germination at the water-activity limit for life

Stevenson, A., Hamill, P. G., Medina, A., Kminek, G., Rummel, J. D., Dijksterhuis, J., Timson, D., Magan, N., Leong, S. L. & Hallsworth, J. E., 13 Nov 2016, In : Environmental Microbiology. 19, p. 947-967 21 p.

Research output: Contribution to journalArticle

Open Access
File
water activity
glycerol
germination
xerophytes
spores

Insight into the mechanism of galactokinase: role of a critical glutamate residue and helix/coil transitions

McAuley, M., Huang, M. & Timson, D., 24 Oct 2016, In : BBA - Proteins and Proteomics. 1865, 3, p. 321-328 8 p.

Research output: Contribution to journalArticle

Open Access
File
Galactokinase
Glutamic Acid
Enzymes
Methionine
Galactosemias

IQGAP1 interaction with RHO family proteins revisited: Kinetic andequilibrium evidence for multiple distinct binding sites

Nouri, K., Fansa, E. K., Amin, E., Dvorsky, R., Gremer, L., Willbold, D., Schmitt, L., Timson, D. & Ahmadian, M. R., 4 Nov 2016, In : Journal of Biological Chemistry. 291, 0, p. 26364-26376 13 p.

Research output: Contribution to journalArticle

Open Access
File
GTP Phosphohydrolases
Binding Sites
Proteins
Cell Polarity
Guanosine Triphosphate

Metabolic Enzymes of Helminth Parasites: Potential as Drug Targets

Timson, D., 31 Dec 2016, In : Current Protein & Peptide Science. 17, 3, p. 280-295 16 p.

Research output: Contribution to journalArticle

Open Access
File

Modulating mobility: a paradigm for protein engineering?

McAuley, M. & Timson, D., 23 Jul 2016, In : Applied Biochemistry and Biotechnology. p. 1-8 8 p.

Research output: Contribution to journalArticle

Open Access
File
Proteins
Ligands
Catalysis
Molecular dynamics
Engineers

Natural small molecules as stabilizers and activators of cancer-associated NQO1 polymorphisms

Pey, A. L., Megarity, C. F., Medina-Carmona, E. & Timson, D., 1 Jan 2016, In : Current Drug Targets. 17, 13, p. 1506-1514 9 p.

Research output: Contribution to journalArticle

Open Access
File
Neoplasms
Pharmacology
Quinones
Protein Stability
NAD

On the Interaction Between Human IQGAP1 and Actin

Magill, D. J., Hamilton, E., Shirran, S. L., Botting, C. H. & Timson, D., 1 Apr 2016, In : Protein and Peptide Letters. 23, 4, p. 386-395 10 p.

Research output: Contribution to journalArticle

Open Access
File
Actins
Proteins
Static Electricity
Cold Climate
Saccharomyces cerevisiae Proteins

Phosphorylation Mechanism of Phosphomevalonate Kinase: Implications for Rational Engineering of Isoprenoid Biosynthetic Pathway Enzymes

Huang, M., Wei, K., Li, X., McClory, J., Hu, G., Zou, J-W. & Timson, D., 27 Sep 2016, In : Journal of Physical Chemistry B. 120, 41, p. 10714-10722 9 p.

Research output: Contribution to journalArticle

Open Access
File
Phosphorylation
Terpenes
Mevalonic Acid
Phosphotransferases
Enzymes
2017

Characterisation of eppin function: expression and activity in the lung

Scott, A., Glasgow, A., Small, D., Carlile, S., McCrudden, M. T. C., McLean, D. T. F., Brown, R., Doherty, D., Lundy, F. T., Hamid, U. I., O'Kane, C. M., McAuley, D. F., Brodlie, M., Tunney, M., Elborn, J. S., Irwin, C. R., Timson, D., Taggart, C. C. & Weldon, S., 13 Jul 2017, In : European Respiratory Journal. 50, 1

Research output: Contribution to journalArticle

Open Access
File
Lipopolysaccharides
Myeloid Cells
Lung
Chemokine CXCL2
Serine Proteinase Inhibitors

Different specificities of two aldehyde dehydrogenases from Saccharomyces cerevisiae var boulardii

Datta, S., Annapore, U. S. & Timson, D., 26 Jan 2017, In : Bioscience Reports. 37, 2

Research output: Contribution to journalArticle

Open Access
File
aldehyde dehydrogenase
aldehydes
Saccharomyces cerevisiae
active sites
isozymes

Enhanced vulnerability of human proteins towards disease-associated inactivation through divergent evolution

Medina-Carmona, E., Fuchs, J. E., Gavira, J. A., Mesa-Torres, N., Neira, J. L., Salido, E., Palomino-Morales, R. J., Burgos, M., Timson, D. & Pey, A. L., 6 Jul 2017, In : Human Molecular Genetics. 26, 18, p. 3531-3544 14 p.

Research output: Contribution to journalArticle

Open Access
File
Proteins
Amino Acids
Mutation
Protein Stability
Genetic Suppression
Open Access
File
Triose-Phosphate Isomerase
Computer Simulation
Mutation
Genes
Amino Acids

LGR5 receptor promotes cell-cell adhesion in stem cells and colon cancer cells via the IQGAP1 -Rac1 pathway

Carmon, K. S., Xing, G., Yi, J., Wu, L., Thomas, A., Moore, C., Masuho, I., Timson, D., Martemyanov, K. A. & Liu, Q. J., 24 Jul 2017, In : Journal of Biological Chemistry. 292, p. 14989-15001 13 p.

Research output: Contribution to journalArticle

Open Access
File
Cell Adhesion
Colonic Neoplasms
Stem Cells
Actins
Catenins

Molecular Genetics of Galactosaemia

Timson, D., 15 May 2017, eLS. Chichester: John Wiley & Sons Ltd

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNChapter

Galactosemias
Molecular Biology
Genes
UDPglucose 4-Epimerase
Galactokinase

New model for the interaction of IQGAP1 with CDC42 and RAC1

Nouri, K., Timson, D. & Ahmadian, M. R., 19 Jun 2017, In : Small GTPases.

Research output: Contribution to journalArticle

Open Access
File
Proteins
GTP Phosphohydrolases
Adhesion
Polarization

Reaction Mechanism of Isopentenyl Phosphate Kinase: A QM/MM Study

McClory, J., Timson, D., Singh, W., Zhang, J. & Huang, M., 20 Nov 2017, In : Journal of Physical Chemistry B. 121, 49, p. 11062-11071 10 p.

Research output: Contribution to journalArticle

Open Access
File
Phosphorylation
Phosphotransferases
Phosphates
Substrates
Metal ions