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2019

Oxytosin as a novel antidegenerative?

Faragher, R. G. A., 1 Jan 2019, (Accepted/In press) In : British Journal of Dermatology. 181, 6, p. 1122-1123 2 p.

Research output: Contribution to journalArticle

Population type influences the rate of ageing

Overall, A. & Faragher, R., 8 Feb 2019, In : Heredity. 123, 2, p. 273-282 10 p.

Research output: Contribution to journalArticle

Open Access
File
Population
Survival Rate
Genetic Drift
Population Density
Gene Frequency
2018

FOXO1 and ETV6 genes may represent novel regulators of splicing factor expression in cellular senescence

Latorre, E., Ostler, E. L., Faragher, R. G. A. & Harries, L. W., 8 Aug 2018, In : The FASEB Journal.

Research output: Contribution to journalArticle

Cell Aging
MAP Kinase Signaling System
Genes
Fibroblasts
Gene Knockdown Techniques

Obesity and type-2 diabetes as inducers of premature cellular senescence and ageing

Burton, D. G. A. & Faragher, R. G. A., 27 Jul 2018, In : Biogerontology. 19, 6, p. 447–459

Research output: Contribution to journalArticle

Open Access
File
Cell Aging
Type 2 Diabetes Mellitus
Obesity
Kidney Diseases
Cardiovascular Diseases

Telomere elongation through hTERT immortalization leads to chromosome repositioning in control cells and genomic instability in Hutchinson-Gilford progeria syndrome fibroblasts, expressing a novel SUN1 isoform

Bikkul, M. U., Faragher, R. G. A., Worthington, G., Meinke, P., Kerr, A. R. W., Sammy, A., Riyahi, K., Horton, D., Schirmer, E. C., Hubank, M., Kill, I. R., Anderson, R. M., Slijepcevic, P., Makarov, E. & Bridger, J. M., 26 Nov 2018, In : Genes Chromosomes and Cancer. 58, 6, p. 341-356

Research output: Contribution to journalArticle

Open Access
File
Progeria
Genomic Instability
Telomere
Protein Isoforms
Fibroblasts
2017

Senescence in the aging process

Faragher, R., McArdle, A., Willows, A. & Ostler, E., 25 Jul 2017, In : F1000 Research. 6

Research output: Contribution to journalArticle

Open Access
File
Phenotype
Transcriptome

Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence

Latorre, E., Birar, V., Sheerin, A., Jeynes, C. C., Hooper, A., Dawe, H., Melzer, D., Cox, L., Faragher, R., Ostler, E. & Harries, L. W., 17 Oct 2017, In : BMC Cell Biology. 18

Research output: Contribution to journalArticle

Open Access
File
Cell Aging
Cell Cycle
Messenger RNA
Telomere
Fibroblasts
2016

Absence of premature senescence in Werner's syndrome keratinocytes

Ibrahim, B., Sheerin, A., Jennert-Burston, K., Bird, J. L. E., Massala, M. V., Illsley, M., James, S. E. & Faragher, R., 2 Aug 2016, In : Experimental Gerontology. 83, p. 139-147 9 p.

Research output: Contribution to journalArticle

Open Access
File
Werner Syndrome
Keratinocytes
Fibroblasts
Cell Aging
Premature Aging
2015

A facile, stereoselective, one-pot synthesis of resveratrol derivatives

Birar, V., Sheerin, A., Milkovicova, J., Faragher, R. & Ostler, E., 20 May 2015, In : Chemistry Central Journal. 9

Research output: Contribution to journalArticle

Open Access
File
Derivatives
Stilbenes
Electrons
Purification
Anti-Inflammatory Agents

Cellular senescence: from growth arrest to immunogenic conversion

Burton, D. G. A. & Faragher, R. G. A., 1 Apr 2015, In : Age. 37, 2, p. 1-19 19 p.

Research output: Contribution to journalArticle

Cell Aging
Fibroblasts
DNA Damage
Growth
Ligands

Preparing for an Aging World: Engaging Biogerontologists, Geriatricians, and the Society

Nikolich-Žugich, J., Goldman, D. P., Cohen, P. R., Cortese, D., Fontana, L., Kennedy, B. K., Mohler, M. J., Olshansky, S. J., Perls, T., Perry, D., Richardson, A., Ritchie, C., Wertheimer, A. M., Faragher, R. & Fain, M. J., 29 Sep 2015, In : Journals of Gerontology, Series A. 71, 4, p. 435-444 10 p.

Research output: Contribution to journalArticle

Medicare
Health Expenditures
Quality of Life
Demography
Education

Should we treat aging as a disease? The consequences and dangers of miscategorisation

Faragher, R., 14 Jul 2015, In : Frontiers in Genetics. 6, p. 171-178 8 p.

Research output: Contribution to journalArticle

Open Access
File
Disease
evidence
consciousness
money
scenario

Suppression of the senescence-associated secretory phenotype (SASP) in human fibroblasts using small molecule inhibitors of p38 MAP kinase and MK2

Alimbetov, D., Davis, T., Brook, A. J. C., Cox, L., Faragher, R., Nurgozhin, T., Zhumadilov, Z. & Kipling, D., 23 Sep 2015, In : Biogerontology. 17, 2, p. 305-315 11 p.

Research output: Contribution to journalArticle

Open Access
File
p38 Mitogen-Activated Protein Kinases
Fibroblasts
Phenotype
Secretory Component
Phase III Clinical Trials
2014

Better immunity in later life: A position paper

Faragher, R., Frasca, D., Remarque, E. & Pawelec, G., 1 Jan 2014, In : Age. 36, 3, p. 1041-1048 8 p.

Research output: Contribution to journalArticle

Immunity
Immune System
Quality of Life
Delivery of Health Care
Education
2013

Biomarkers, interventions and healthy ageing

Kenessary, A., Zhumadilov, Z., Nurgozhin, T., Kipling, D., Yeoman, M., Cox, L., Ostler, E. & Faragher, R., 25 May 2013, In : New Biotechnology. 30, 4, p. 373-377 5 p.

Research output: Contribution to journalArticle

Biomarkers
Aging of materials
Morbidity
Quality of Life
Pathology
2012

Characterization of cellular senescence mechanisms in human corneal endothelial cells

Sheerin, A., Smith, S. K., Jennert-Burston, K., Brook, A. J., Allen, M., Ibrahim, B., Jones, D. L., Wallis, C., Engelmann, K., Rhys-Williams, W., Faragher, R. & Kipling, D., Apr 2012, In : Aging Cell. 11, 2, p. 234-240 7 p.

Research output: Contribution to journalArticle

Editorial: a systematic end to "muddling through"?

Faragher, R. (ed.) & Ostler, E. (ed.), 28 Feb 2012, UK: Springer-Verlag. 2 p.

Research output: Book/ReportBook - edited

Insights into CNS ageing from animal models of senescence

Yeoman, M., Scutt, G. & Faragher, R., 30 Jun 2012, In : Nature Reviews Neuroscience. 13, 6, p. 435-445 11 p.

Research output: Contribution to journalArticle

Recapitulation of Werner syndrome sensitivity to camptothecin by limited knockdown of the WRN helicase/exonuclease

Bird, J. L. E., Jennert-Burston, K., Bacheler, M. A., Mason, P. A., Lowe, J. E., Heo, S. J., Campisi, J., Faragher, R. & Cox, L. S., 28 Feb 2012, In : Biogerontology. 13, 1

Research output: Contribution to journalArticle

Werner Syndrome
Camptothecin
Exonucleases
Topoisomerase Inhibitors
Fibroblasts
2011

Chemical analysis of aging: testing predictions from green theory

Ostler, E., Iqbal, A., Faragher, R., Naughton, D., Piper, M. & Partridge, L., 2011, p. 64.

Research output: Contribution to conferenceAbstract

File
Drosophila melanogaster
Genetic Engineering
Diptera
Drosophila

Resveratrol, but not dihydroresveratrol, induces premature senescence in primary human fibroblasts

Faragher, R., Burton, D., Majecha, P., Fong, N. S., Davis, T., Sheerin, A. & Ostler, E., 12 Feb 2011, In : Age. 33, 4, p. 555-564 10 p.

Research output: Contribution to journalArticle