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• 2019

  Oxytosin as a novel antidegenerative?

  Faragher, R. G. A., 23 Oct 2019, In : British Journal of Dermatology. 181, 6, p. 1122-1123 2 p.

  Research output: Contribution to journal › Article

• Population type influences the rate of ageing

  Overall, A. & Faragher, R., 8 Feb 2019, In : Heredity. 123, 2, p. 273-282 10 p.

  Research output: Contribution to journal › Article

  Open Access

  File

  • mutation accumulation
  • survival rate
  • effective population size
  • genetic drift
  • human population
• 2018

  FOXO1 and ETV6 genes may represent novel regulators of splicing factor expression in cellular senescence

  Latorre, E., Ostler, E. L., Faragher, R. G. A. & Harries, L. W., 8 Aug 2018, In : The FASEB Journal. 33, 1, p. 1086-1097

  Research output: Contribution to journal › Article

  • RNA Splicing Factors
  • Cellular Senescence
  • MAP Kinase Signaling System
  • Genes
  • Fibroblasts

• Obesity and type-2 diabetes as inducers of premature cellular senescence and ageing

  Burton, D. G. A. & Faragher, R. G. A., 27 Jul 2018, In : Biogerontology. 19, 6, p. 447–459

  Research output: Contribution to journal › Article

  Open Access

  File

  • Cellular Senescence
  • Type 2 Diabetes Mellitus
  • Obesity
  • Kidney Diseases
  • Cardiovascular Diseases

• Telomere elongation through hTERT immortalization leads to chromosome repositioning in control cells and genomic instability in Hutchinson-Gilford progeria syndrome fibroblasts, expressing a novel SUN1 isoform

  Bikkul, M. U., Faragher, R. G. A., Worthington, G., Meinke, P., Kerr, A. R. W., Sammy, A., Riyahi, K., Horton, D., Schirmer, E. C., Hubank, M., Kill, I. R., Anderson, R. M., Slijepcevic, P., Makarov, E. & Bridger, J. M., 26 Nov 2018, In : Genes Chromosomes and Cancer. 58, 6, p. 341-356

  Research output: Contribution to journal › Article

  Open Access

  File

  • Progeria
  • human TERT protein
  • Telomere
  • Genomic Instability
  • Protein Isoforms
• 2017

  Senescence in the aging process

  Faragher, R., McArdle, A., Willows, A. & Ostler, E., 25 Jul 2017, In : F1000 Research. 6

  Research output: Contribution to journal › Article

  Open Access

  File

  • senescence (aging)
  • phenotype
  • cells
  • transcriptome
  • tissues

• Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence

  Latorre, E., Birar, V., Sheerin, A., Jeynes, C. C., Hooper, A., Dawe, H., Melzer, D., Cox, L., Faragher, R., Ostler, E. & Harries, L. W., 17 Oct 2017, In : BMC Cell Biology. 18, 31.

  Research output: Contribution to journal › Article

  Open Access

  File

  • RNA Splicing Factors
  • Cellular Senescence
  • Cell Cycle
  • Resveratrol
  • Messenger RNA
• 2016

  Absence of premature senescence in Werner's syndrome keratinocytes

  Ibrahim, B., Sheerin, A., Jennert-Burston, K., Bird, J. L. E., Massala, M. V., Illsley, M., James, S. E. & Faragher, R., 2 Aug 2016, In : Experimental Gerontology. 83, p. 139-147 9 p.

  Research output: Contribution to journal › Article

  Open Access

  File

  • Werner Syndrome
  • Keratinocytes
  • Fibroblasts
  • Cellular Senescence
  • Premature Aging
• 2015

  A facile, stereoselective, one-pot synthesis of resveratrol derivatives

  Birar, V., Sheerin, A., Milkovicova, J., Faragher, R. & Ostler, E., 20 May 2015, In : Chemistry Central Journal. 9

  Research output: Contribution to journal › Article

  Open Access

  File

  • Resveratrol
  • Derivatives
  • Electrons
  • Stilbenes
  • Drug Discovery

• Cellular senescence: from growth arrest to immunogenic conversion

  Burton, D. G. A. & Faragher, R. G. A., 1 Apr 2015, In : Age. 37, 2, p. 1-19 19 p.

  Research output: Contribution to journal › Article

  • Cellular Senescence
  • Fibroblasts
  • DNA Damage
  • Growth
  • Ligands

• Preparing for an Aging World: Engaging Biogerontologists, Geriatricians, and the Society

  Nikolich-Žugich, J., Goldman, D. P., Cohen, P. R., Cortese, D., Fontana, L., Kennedy, B. K., Mohler, M. J., Olshansky, S. J., Perls, T., Perry, D., Richardson, A., Ritchie, C., Wertheimer, A. M., Faragher, R. & Fain, M. J., 29 Sep 2015, In : Journals of Gerontology, Series A. 71, 4, p. 435-444 10 p.

  Research output: Contribution to journal › Article

  • disability
  • chronic condition
  • health professionals
  • expenditures
  • quality of life

• Should we treat aging as a disease? The consequences and dangers of miscategorisation

  Faragher, R., 14 Jul 2015, In : Frontiers in Genetics. 6, p. 171-178 8 p.

  Research output: Contribution to journal › Article

  Open Access

  File

  • consciousness
  • evidence
  • money
  • Healthcare
  • scenario

• Suppression of the senescence-associated secretory phenotype (SASP) in human fibroblasts using small molecule inhibitors of p38 MAP kinase and MK2

  Alimbetov, D., Davis, T., Brook, A. J. C., Cox, L., Faragher, R., Nurgozhin, T., Zhumadilov, Z. & Kipling, D., 23 Sep 2015, In : Biogerontology. 17, 2, p. 305-315 11 p.

  Research output: Contribution to journal › Article

  Open Access

  File

  • Cellular Senescence
  • p38 Mitogen-Activated Protein Kinases
  • Fibroblasts
  • BIRB 796
  • SB 203580
• 2014

  Better immunity in later life: A position paper

  Faragher, R., Frasca, D., Remarque, E. & Pawelec, G., 1 Jan 2014, In : Age. 36, 3, p. 1041-1048 8 p.

  Research output: Contribution to journal › Article

  • Immunosenescence
  • Immunity
  • Immune System
  • Quality of Life
  • Education
• 2013

  Biomarkers, interventions and healthy ageing

  Kenessary, A., Zhumadilov, Z., Nurgozhin, T., Kipling, D., Yeoman, M., Cox, L., Ostler, E. & Faragher, R., 25 May 2013, In : New Biotechnology. 30, 4, p. 373-377 5 p.

  Research output: Contribution to journal › Article

  • Healthy Aging
  • Biomarkers
  • Aging of materials
  • Morbidity
  • Pathology
• 2012

  Characterization of cellular senescence mechanisms in human corneal endothelial cells

  Sheerin, A., Smith, S. K., Jennert-Burston, K., Brook, A. J., Allen, M., Ibrahim, B., Jones, D. L., Wallis, C., Engelmann, K., Rhys-Williams, W., Faragher, R. & Kipling, D., Apr 2012, In : Aging Cell. 11, 2, p. 234-240 7 p.

  Research output: Contribution to journal › Article

• Editorial: a systematic end to "muddling through"?

  Faragher, R. (ed.) & Ostler, E. (ed.), 28 Feb 2012, UK: Springer-Verlag. 2 p.

  Research output: Book/Report › Book - edited

• Insights into CNS ageing from animal models of senescence

  Yeoman, M., Scutt, G. & Faragher, R., 30 Jun 2012, In : Nature Reviews Neuroscience. 13, 6, p. 435-445 11 p.

  Research output: Contribution to journal › Article

• Recapitulation of Werner syndrome sensitivity to camptothecin by limited knockdown of the WRN helicase/exonuclease

  Bird, J. L. E., Jennert-Burston, K., Bacheler, M. A., Mason, P. A., Lowe, J. E., Heo, S. J., Campisi, J., Faragher, R. & Cox, L. S., 28 Feb 2012, In : Biogerontology. 13, 1

  Research output: Contribution to journal › Article

  • Werner Syndrome
  • Exonucleases
  • Camptothecin
  • Topoisomerase Inhibitors
  • RecQ Helicases
• 2011

  Chemical analysis of aging: testing predictions from green theory

  Ostler, E., Iqbal, A., Faragher, R., Naughton, D., Piper, M. & Partridge, L., 2011, p. 64.

  Research output: Contribution to conference › Abstract

  File

  • Drosophila melanogaster
  • Genetic Engineering
  • Diptera
  • Drosophila
  • Longevity

• Resveratrol, but not dihydroresveratrol, induces premature senescence in primary human fibroblasts

  Faragher, R., Burton, D., Majecha, P., Fong, N. S., Davis, T., Sheerin, A. & Ostler, E., 12 Feb 2011, In : Age. 33, 4, p. 555-564 10 p.

  Research output: Contribution to journal › Article