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• 2019

  Myosin Va and spermine synthase: partners in exosome transport

  Timson, D., 30 Apr 2019, In: Bioscience Reports. 39, 4, p. 1-5 5 p., BSR20190326.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Spermine Synthase
  • Exosomes
  • Griscelli syndrome type 1
  • Myosins
  • Snyder Robinson syndrome
• 2014

  Calcium binding proteins in the liver fluke, Fasciola Hepatica

  Russell, S. L. & Timson, D. J., 1 Jan 2014, New Developments in Calcium Signaling Research. Nova Science Publishers Inc, p. 89-103 15 p.

  Research output: Chapter in Book/Conference proceeding with ISSN or ISBN › Chapter › peer-review

  • Fasciola hepatica
  • Calcium-Binding Proteins
  • Liver
  • Parasites
  • Mammals
• 2020

  Pilot Evaluation of Two Fasciola hepatica Biomarkers for Supporting Triclabendazole (TCBZ) Efficacy Diagnostics

  Collett, C. F., Morphew, R. M., Timson, D., Phillips, H. C. & Brophy, P. M., 30 Jul 2020, In: Molecules (Basel, Switzerland). 25, 15, 3477.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Triclabendazole
  • parasites
  • Fasciola hepatica
  • biomarkers
  • Biomarkers
• 2014

  Cause or effect: which genetic changes are associated with cancer?

  Timson, D., 2014, In: Gene, Cell and Tissue. 1, 3, e23818.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• The Saccharomyces cerevisiae quinone oxidoreductase Lot6p: stability, inhibition and cooperativity

  Megarity, C. F., Looi, H. K. & Timson, D., 31 Aug 2014, In: Fems Yeast Research. 14, 5, p. 797-807 11 p.

  Research output: Contribution to journal › Article › peer-review

• The metastability of human UDP-galactose 4 '-epimerase (GALE) is increased by variants associated with type III galactosemia but decreased by substrate and cofactor binding

  Pey, A. L., Padin-Gonzalez, E., Timson, D. & Mesa-Torres, N., 15 Nov 2014, In: Archives of Biochemistry and Biophysics. 562, p. 103-114 12 p.

  Research output: Contribution to journal › Article › peer-review

• 2015

  FhCaBP2: a Fasciola hepatica calcium-binding protein with EF-hand and dynein light chain domains

  Thomas, C. M. & Timson, D., 30 Sep 2015, In: Parasitology. 142, 11, p. 1375-1386 12 p.

  Research output: Contribution to journal › Article › peer-review

• 2012

  Galactokinases: Potential Biotechnological Applications as Biocatalysts

  Kristiansson, H. & Timson, D., 2012, In: Current Biotechnology. 1, 2, p. 148-154 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Galactose
  • Galactokinase
  • Enzymes
  • Phosphorylation
  • Escherichia coli
• 2014

  Biochemical characterisation of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) from the liver fluke, Fasciola hepatica

  Zinsser, V. L., Hoey, E. M., Trudgett, A. & Timson, D., 30 Apr 2014, In: BBA - Proteins and Proteomics. 1844, 4, p. 744-749 6 p.

  Research output: Contribution to journal › Article › peer-review

• 2019

  Characterization of Calcium-Binding Proteins from Parasitic Worms

  Thomas, C. M. & Timson, D. J., 2 Feb 2019, Calcium-Binding Proteins of the EF-Hand Superfamily. Heizmann, C. (ed.). New York: Humana Press, Vol. 1929. p. 615-641 27 p. (Methods in molecular biology (Clifton, N.J.)).

  Research output: Chapter in Book/Conference proceeding with ISSN or ISBN › Chapter › peer-review

  • Calcium-Binding Proteins
  • Helminths
  • Calcium Signaling
  • Helminth Proteins
  • Disease Resistance
• 2017

  Molecular Genetics of Galactosaemia

  Timson, D., 15 May 2017, eLS. Chichester: John Wiley & Sons Ltd

  Research output: Chapter in Book/Conference proceeding with ISSN or ISBN › Chapter › peer-review

  • Galactosemias
  • Molecular Biology
  • UDPglucose 4-Epimerase
  • Galactokinase
  • Genes
• 2015

  Quantitative enzymology

  Timson, D. J., 1 Jul 2015, In: Current Enzyme Inhibition. 11, 1, p. 12-31 20 p.

  Research output: Contribution to journal › Article › peer-review

  • Enzymes
  • Enzyme kinetics
  • Biotechnology
  • Kinetics
  • Molecules
• 2016

  FhCaBP1 (FH22): a Fasciola hepatica calcium-binding protein with EF-hand and dynein light chain domains

  Thomas, C. M., Cheung, S. & Timson, D., 28 Sep 2016, In: Experimental Parasitology. 170, p. 109-115 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • EF Hand Motifs
  • Fasciola hepatica
  • Dyneins
  • Calcium-Binding Proteins
  • Ions
• 2015

  The molecular basis of galactosemia — Past, present and future

  Timson, D. J., 2 Jul 2015, In: Gene. 589, 2, p. 133-141 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Galactosemias
  • Galactose
  • galactose epimerase
  • UDPglucose 4-Epimerase
  • galactose-1-phosphate
• 2016

  Fasciola hepaticacalcium binding protein FhCaBP2: Structure of the dynein light chain-like domain

  Nguyen, T. H., Thomas, C. M., Timson, D. & Van Raaij, M. J., 16 Apr 2016, In: Parasitology Research. 115, 7, p. 2879-2886 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Fasciola
  • Fasciola hepatica
  • Dyneins
  • Carrier Proteins
  • EF Hand Motifs
• 2018

  Improving the activity and stability of human galactokinase for therapeutic and biotechnological applications

  McAuley, M., Mesa-Torres, N., McFall, A., Morris, S., Huang, M., Pey, A. L. & Timson, D., 26 Apr 2018, In: ChemBioChem. 19, 10, p. 1088-1095 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Galactokinase
  • Enzymes
  • Substrates
  • Enzyme activity
  • Proteins
• 2016

  Natural small molecules as stabilizers and activators of cancer-associated NQO1 polymorphisms

  Pey, A. L., Megarity, C. F., Medina-Carmona, E. & Timson, D., 1 Jan 2016, In: Current Drug Targets. 17, 13, p. 1506-1514 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Neoplasms
  • Quinones
  • Pharmacology
  • quinone
  • Protein Stability
• 2017

  Different specificities of two aldehyde dehydrogenases from Saccharomyces cerevisiae var boulardii

  Datta, S., Annapore, U. S. & Timson, D., 26 Jan 2017, In: Bioscience Reports. 37, 2

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Aldehyde Dehydrogenase
  • Aldehydes
  • Yeast
  • Substrates
  • Isoenzymes
• 2019

  Catalytic mechanism of mevalonate kinase revisited, a QM/MM study

  McClory, J., Lin, J. T., Timson, D., Zhang, J. & Huang, M., 5 Feb 2019, In: Organic and Biomolecular Chemistry. 17, 9, p. 2423-2431 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • mevalonate kinase
  • Mevalonic Acid
  • Biofuels
  • Adenosine Triphosphate
  • Phosphorylation
• 2016

  Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands

  Medina-Carmona, E., Palomino-Morales, R. J., Fuchs, J. E., Padin-Gonzalez, E., Mesa-Torres, N., Salido, E., Timson, D. & Pey, A. L., 3 Feb 2016, In: Scientific Reports. 6

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Flavin-Adenine Dinucleotide
  • Ligands
  • Pharmacology
  • human NQO1 protein
  • Neoplasms
• 2015

  Multiplication of microbes below 0.690 water activity: implications for terrestrial and extraterrestrial life

  Stevenson, A., Burkhardt, J., Cockell, C. S., Cray, J. A., Dijksterhuis, J., Fox-Powell, M., Kee, T. P., Kminek, G., McGenity, T. J. & Timson, D., 28 Feb 2015, In: Environmental Microbiology. 17, 2, p. 257-277 21 p.

  Research output: Contribution to journal › Article › peer-review
• 2019

  NQO1: A target for the treatment of cancer and neurological diseases, and a model to understand loss of function disease mechanisms

  Beaver, S. K., Mesa-Torres, N., Pey, A. L. & Timson, D. J., 12 May 2019, In: BBA - Proteins and Proteomics. 1867, 7-8, p. 663-676 14 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Flavin-Adenine Dinucleotide
  • NAD
  • Detoxification
  • Proteins
  • Quinones
• 2020

  In Silico Analysis of the Effects of Point Mutations on α-Globin: Implications for α-Thalassemia

  Horri-Naceur, A. & Timson, D. J., 18 May 2020, In: Hemoglobin. 44, 2, p. 89-103 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Globins
  • Thalassemia
  • Point Mutation
  • Computer Simulation
  • Mutation
• 2016

  A mysterious family of calcium-binding proteins from parasitic worms

  Thomas, C. M. & Timson, D. J., 15 Aug 2016, In: Biochemical Society Transactions. 44, 4, p. 1005-1010 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Calcium-Binding Proteins
  • Helminths
  • Ions
  • Calcium
  • EF Hand Motifs
• 2019

  Repurposing drugs for the treatment of galactosemia

  Timson, D., 22 Oct 2019, In: Expert Opinion on Orphan Drugs. 7, 10, p. 443-451 9 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Galactosemias
  • Drug Repositioning
  • Galactose
  • Phosphates
  • Ipomoea batatas
• 2016

  Galactokinase promiscuity: A question of flexibility?

  McAuley, M., Kristiansson, H., Huang, M., Pey, A. L. & Timson, D. J., 9 Feb 2016, In: Biochemical Society Transactions. 44, p. 116-122 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Galactokinase
  • Galactosemias
  • Sugars
  • Catalytic Domain
  • Enzymes

• IQGAP1 interaction with RHO family proteins revisited: Kinetic andequilibrium evidence for multiple distinct binding sites

  Nouri, K., Fansa, E. K., Amin, E., Dvorsky, R., Gremer, L., Willbold, D., Schmitt, L., Timson, D. & Ahmadian, M. R., 4 Nov 2016, In: Journal of Biological Chemistry. 291, 0, p. 26364-26376 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • GTP Phosphohydrolases
  • Binding Sites
  • Kinetics
  • Proteins
  • Cell Polarity

• Characterization of Cd36_03230p, a putative vanillin dehydrogenase from Candida dubliniensis

  Datta, S., Annapure, U. S. & Timson, D., 14 Oct 2016, In: RSC Advances. 6, 102, p. 99774-99780 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • vanillin dehydrogenase
  • Candida
  • Substrates
  • Aldehyde Dehydrogenase
  • Yeast
• 2017

  Site-to-site interdomain communication may mediate different loss-of-function mechanisms in a cancer-associated NQO1 polymorphism

  Medina-Carmona, E., Neira, J. L., Salido, E., Fuchs, J. E., Palomino-Morales, R. J., Timson, D. & Pey, A. L., 14 Mar 2017, In: Scientific Reports. 7

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Flavin-Adenine Dinucleotide
  • quinone
  • Prodrugs
  • Proteins
  • Enzymes
• 2016

  Glycerol enhances fungal germination at the water-activity limit for life

  Stevenson, A., Hamill, P. G., Medina, A., Kminek, G., Rummel, J. D., Dijksterhuis, J., Timson, D., Magan, N., Leong, S. L. & Hallsworth, J. E., 13 Nov 2016, In: Environmental Microbiology. 19, p. 947-967 21 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • water activity
  • glycerol
  • germination
  • xerophytes
  • biosphere
• 2017

  Characterisation of eppin function: expression and activity in the lung

  Scott, A., Glasgow, A., Small, D., Carlile, S., McCrudden, M. T. C., McLean, D. T. F., Brown, R., Doherty, D., Lundy, F. T., Hamid, U. I., O'Kane, C. M., McAuley, D. F., Brodlie, M., Tunney, M., Elborn, J. S., Irwin, C. R., Timson, D., Taggart, C. C. & Weldon, S., 13 Jul 2017, In: European Respiratory Journal. 50, 1

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Lipopolysaccharides
  • Myeloid Cells
  • Lung
  • Chemokine CXCL2
  • Serine Proteinase Inhibitors
• 2018

  The mechanism of action of praziquantel: can new drugs exploit similar mechanisms?

  Thomas, C. & Timson, D., 26 Sep 2018, In: Current Medicinal Chemistry. 25, 1

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Praziquantel
  • Pharmaceutical Preparations
  • Calcium Channels
  • Paralysis
  • Ions
• 2017

  UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-6 (pp-GalNAc-T6): Role in cancer and prospects as a drug target

  Banford, S. & Timson, D., 1 Jan 2017, In: Current Cancer Drug Targets. 17, 1, p. 53-61 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • UDP-N-acetylgalactosamine polypeptide N-acetylgalactosaminyltransferase 6
  • polypeptide N-acetylgalactosaminyltransferase
  • Acetylgalactosamine
  • Uridine Diphosphate
  • Galactosamine
• 2016

  Calmodulin disruption impacts growth and motility in juvenile liver fluke

  Timson, D., 27 Jan 2016, In: Parasites & Vectors. 9, p. 1-13 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • liver flukes
  • calmodulin
  • calcium
  • blood flukes
  • excretory-secretory products
• 2017

  We are all mutants

  Timson, D., 2017, In: School Science Review. 99, 366, p. 45-50

  Research output: Contribution to journal › Article › peer-review

  • Down syndrome
  • social sciences
  • mutation
  • genetic disorders
  • mutants
• 2016

  On the Interaction Between Human IQGAP1 and Actin

  Magill, D. J., Hamilton, E., Shirran, S. L., Botting, C. H. & Timson, D., 1 Apr 2016, In: Protein and Peptide Letters. 23, 4, p. 386-395 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Actins
  • calponin
  • Static Electricity
  • Proteins
  • Cold Climate
• 2014

  UDP-galactose-4-epimerase (GALE)

  McCorvie, T. J. & Timson, D. J., 5 Feb 2014, Handbook of Glycosyltransferases and Related Genes, Second Edition. Springer Japan, Vol. 2. p. 1449-1464 16 p.

  Research output: Chapter in Book/Conference proceeding with ISSN or ISBN › Chapter › peer-review

  • UDPglucose 4-Epimerase
  • Uridine Diphosphate
  • Monosaccharides
  • Galactose
  • Enzymes

• FAD binding overcomes defects in activity and stability displayed by cancer-associated variants of human NQO1

  Pey, A. L., Megarity, C. F. & Timson, D., 30 Nov 2014, In: BBA - Molecular Basis of Disease. 1842, 11, p. 2163-2173 11 p.

  Research output: Contribution to journal › Article › peer-review
• 2020

  Targeting HIF-1α Function in Cancer through the Chaperone Action of NQO1

  Salido, E., Timson, D. J., Betancor-Fernández, I., Palomino-Morales, R. & Pey, A. L., 18 Mar 2020

  Research output: Other contribution

  Open Access

  File

• Therapies for galactosemia: a patent landscape

  Timson, D. J., 21 Apr 2020, In: Pharmaceutical Patent Analyst.

  Research output: Contribution to journal › Article › peer-review
• 2016

  Disturbed cofactor binding by a novel mutation in UDP-galactose 4 '-epimerase results in a type III galactosemia phenotype at birth

  Paul, S., McCorvie, T. J., Zschocke, J. & Timson, D., 3 Feb 2016, In: RSC Advances. 6, 21, p. 17297-17301 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • galactose epimerase
  • UDPglucose 4-Epimerase
  • Galactosemias
  • Galactose
  • Parturition
• 2015

  In Silico Prediction of the Effects of Mutations in the Human Mevalonate Kinase Gene: Towards a Predictive Framework for Mevalonate Kinase Deficiency

  Browne, C. & Timson, D., 30 Nov 2015, In: Annals of Human Genetics. 79, 6, p. 451-459 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2019

  Phosphorylation Mechanism of N-acetyl-L-Glutamate Kinase, a QM/MM Study

  McClory, J., Hu, G-X., Zou, J-W., Timson, D. J. & Huang, M., 8 Mar 2019, In: Journal of Physical Chemistry B. 123, 13, p. 2844-2852 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • acetylglutamate kinase
  • glutamate 5-kinase
  • Phosphorylation
  • phosphorylation
  • glutamates

• Dynamic origins of substrate promiscuity in bacterial galactokinases

  McAuley, M., Huang, M. & Timson, D., 17 Oct 2019, In: Carbohydrate Research. 486, 107839.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Substrates
  • Enzymes
  • Escherichia coli
  • Sugars
  • Galactokinase

• A Dynamic Core in Human NQO1 Controls the Functional and Stability Effects of Ligand Binding and Their Communication across the Enzyme Dimer

  Vankova, P., Salido, E., Timson, D., Man, P. & Pey, A. L., 12 Nov 2019, In: Biomolecules. 9, 11, 728.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Flavin-Adenine Dinucleotide
  • Communication
  • Ligands
  • Enzymes
  • human NQO1 protein
• 2018

  Prenatal Alcohol Exposure, Biomarkers and Foetal Alcohol Spectrum Disorders

  Gard, P., Zanganeh, M. & Timson, D., Nov 2018, Fetal Alcohol Syndrome: Recognition, Differential Diagnosis and Long-Term Effects. Knight, D. (ed.). Nova Science Publishers Inc, p. 19-57 38 p.

  Research output: Chapter in Book/Conference proceeding with ISSN or ISBN › Chapter › peer-review

  • Fetal Alcohol Spectrum Disorders
  • Alcohols
  • Biomarkers
  • diethyl sulfate
  • ethyl glucuronide
• 2017

  Enhanced vulnerability of human proteins towards disease-associated inactivation through divergent evolution

  Medina-Carmona, E., Fuchs, J. E., Gavira, J. A., Mesa-Torres, N., Neira, J. L., Salido, E., Palomino-Morales, R. J., Burgos, M., Timson, D. & Pey, A. L., 6 Jul 2017, In: Human Molecular Genetics. 26, 18, p. 3531-3544 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Amino Acids
  • Proteins
  • Protein Stability
  • Mutation
  • Alanine-glyoxylate transaminase
• 2018

  Natural (and Unnatural) Small Molecules as Pharmacological Chaperones and Inhibitors in Cancer

  Betancor-Fernández, I., Timson, D. J., Salido, E. & Pey, A. L., 1 Jan 2018, Targeting Trafficking in Drug Development. Ulloa-Aguirre, A. & Tao, Y. X. (eds.). Springer, p. 155-190 36 p. (Handbook of Experimental Pharmacology; vol. 245).

  Research output: Chapter in Book/Conference proceeding with ISSN or ISBN › Chapter › peer-review

  • Molecules
  • Pharmacology
  • Protein Stability
  • Convergence of numerical methods
  • Proteins

• The tegumental allergen-like proteins of Schistosoma mansoni: a biochemical study of SmTAL4-TAL13

  Carson, J., Thomas, C. M., McGinty, A., Takata, G. & Timson, D., 14 Feb 2018, In: Molecular and Biochemical Parasitology. 221, p. 14-22 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Schistosoma mansoni
  • allergens
  • ions
  • hands
  • proteins
• 2017

  Reaction Mechanism of Isopentenyl Phosphate Kinase: A QM/MM Study

  McClory, J., Timson, D., Singh, W., Zhang, J. & Huang, M., 20 Nov 2017, In: Journal of Physical Chemistry B. 121, 49, p. 11062-11071 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Phosphorylation
  • Phosphates
  • Phosphotransferases
  • Metal ions
  • Substrates