Abstract
While intraocular lenses (IOL) are used to restore visual acuity in cataract patients, they are limited in their development as no clinically available lens can effectively mimic the accommodative function of the eye's natural lens. The optoelectronic properties of 2D transition metal carbides and/or nitrides (MXenes), including high electronic conductivity, optical transparency, flexibility, biocompatibility, and hydrophilicity, suggest potential use within an accommodating IOL. This study investigates the use of Ti3C2Tx (MXene) as a transparent, conductive electrode to allow changes in optical power. Ti3C2Tx is synthesized and spin‐coated on hydrophobic acrylate IOLs, achieving a sheet resistance ranging from 0.2–1.0 kΩ sq−1 with 50–80% transmittance in the visible region. Human lens epithelial and monocytic cells show no cytotoxic nor inflammatory response to the coated lenses. An adjustable focus test cell is fabricated using a liquid crystal (LC) layer sandwiched between Ti3C2Tx coatings on a solid support. Molecular reorientation of the LC layer, through an applied electric field, results in changes in optical power as objects viewed through the test cell appeared in and out of focus. This study is the first step toward the use of Ti3C2Tx within an accommodative IOL design through demonstration of reversible, controlled, adjustable focus.
Original language | English |
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Article number | 2000841 |
Pages (from-to) | 1-9 |
Number of pages | 9 |
Journal | Advanced Functional Materials |
Volume | 30 |
Issue number | 47 |
DOIs | |
Publication status | Published - 10 May 2020 |
Bibliographical note
© 2020 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and repro-duction in any medium, provided the original work is properly cited.Keywords
- Accommodating intraocular lens
- Liquid crystals
- MXene
- nanomaterials
- Ophthalmic medical device
- Optoelectronic materials
- accommodating intraocular lens
- ophthalmic medical device
- liquid crystals
- optoelectronic materials
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Cyril Crua
- School of Arch, Tech and Eng - Visiting Professor
- Advanced Engineering Centre
Person: Visiting Scholar, Academic
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Marcus Dymond
- School of Applied Sciences - Subject Lead Biomed and Biomolecular Sci, Principal Lecturer
- Applied Chemical Sciences Research Excellence Group
- Centre for Lifelong Health
Person: Academic
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Susan Sandeman
- School of Applied Sciences - Professor of Biomaterials and Tissue Eng.
- Applied Chemical Sciences Research Excellence Group
- Centre for Lifelong Health
- Centre for Regenerative Medicine and Devices
Person: Academic