Project Details
Description
The intestinal tract plays a significant role in food digestion, fluid and electrolyte transport, drug absorption and metabolism, and nutrient uptake. The mucosal epithelium act as a key barrier that uses chemical communication to drive motility tones which maximise fluid, electrolyte, and nutrient uptake.
Therefore, it is critical to effectively study the processes that regulate mucosal epithelium chemical signalling and how this can be impacted by environmental toxins, drugs, nutrients, and pharmaceuticals.
At present electrochemical sensors have been widely used to measure chemical signalling processes from ex vivo tissue, however these studies are limited due to the viability of the tissue and lack of a realistic measurement environment.
To achieve this, this overseas travel award aims to learn about how microfluidic devices developed in the Henry group at Colorado State University can be used to sustain ex vivo tissues for longer durations.
This new collaboration will focus on interfacing our existing approaches in electrochemical sensing within microfluidic devices to develop new measurement tools which can provide long-term culture and chemical monitoring of ex vivo intestinal models.
Therefore, it is critical to effectively study the processes that regulate mucosal epithelium chemical signalling and how this can be impacted by environmental toxins, drugs, nutrients, and pharmaceuticals.
At present electrochemical sensors have been widely used to measure chemical signalling processes from ex vivo tissue, however these studies are limited due to the viability of the tissue and lack of a realistic measurement environment.
To achieve this, this overseas travel award aims to learn about how microfluidic devices developed in the Henry group at Colorado State University can be used to sustain ex vivo tissues for longer durations.
This new collaboration will focus on interfacing our existing approaches in electrochemical sensing within microfluidic devices to develop new measurement tools which can provide long-term culture and chemical monitoring of ex vivo intestinal models.
Status | Active |
---|---|
Effective start/end date | 1/01/25 → 30/06/26 |
Funding
- EPSRC
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