Project Details
Description
Sports science and health researchers collaborated with Brighton Marathon on an investigation into changes in the levels of a protein called troponin during marathon running. The partners conducted the Brighton Marathon Heart Study at the 2017 Brighton Marathon.
Troponin is a protein present in the cells of the heart that is released into the blood when the heart muscle is stressed or damaged. Previous studies have demonstrated that exercise can cause a rise in troponin levels. This study planned to increase our understanding of the significance of this rise.
Part of the project was to compare troponin levels between runners with or without heart disease (for example, valvular heart disease, atrial fibrillation, ischaemic heart disease, cardiomyopathy or hypertension with left ventricular hypertrophy).
This research was undertaken between January and July 2017, with the exercise testing session taking place on 18-19 and 25-26 March 2017 and the Brighton Marathon on 9 April 2017.
The project aimed to quantify the changes in troponin levels in marathon runners with and without structural heart disease and relate these changes to the exercise intensity run during the marathon.
Researchers carried out two studies.
Study one: Participants provided a small blood sample before and after the marathon. One group provided one sample before, at the pre-race exhibition, and gave their second sample shortly after the race in the finish line medical tent. The other group gave both these samples, and additional blood samples at one, three, six and 24 hours after they have finished the marathon.
Study two: Participants completed a short exercise test at our sport science laboratories in Eastbourne in March 2017. Again, small blood samples weretaken before and after the race. In addition, a heart monitor was worn during the race.
The university researchers partnered with:
Dr Rachael Grimaldi, Associate Medical Director, Brighton Marathon
Dr Todd Leckie, Junior Anaesthetics Trainee
and Brighton Marathon
Troponin is a protein present in the cells of the heart that is released into the blood when the heart muscle is stressed or damaged. Previous studies have demonstrated that exercise can cause a rise in troponin levels. This study planned to increase our understanding of the significance of this rise.
Part of the project was to compare troponin levels between runners with or without heart disease (for example, valvular heart disease, atrial fibrillation, ischaemic heart disease, cardiomyopathy or hypertension with left ventricular hypertrophy).
This research was undertaken between January and July 2017, with the exercise testing session taking place on 18-19 and 25-26 March 2017 and the Brighton Marathon on 9 April 2017.
The project aimed to quantify the changes in troponin levels in marathon runners with and without structural heart disease and relate these changes to the exercise intensity run during the marathon.
Researchers carried out two studies.
Study one: Participants provided a small blood sample before and after the marathon. One group provided one sample before, at the pre-race exhibition, and gave their second sample shortly after the race in the finish line medical tent. The other group gave both these samples, and additional blood samples at one, three, six and 24 hours after they have finished the marathon.
Study two: Participants completed a short exercise test at our sport science laboratories in Eastbourne in March 2017. Again, small blood samples weretaken before and after the race. In addition, a heart monitor was worn during the race.
The university researchers partnered with:
Dr Rachael Grimaldi, Associate Medical Director, Brighton Marathon
Dr Todd Leckie, Junior Anaesthetics Trainee
and Brighton Marathon
| Status | Finished |
|---|---|
| Effective start/end date | 1/01/17 → 31/07/17 |
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