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Personal profile

Research interests

Within the multidisciplinary field of regenerative medicine, my specific research interests lie in two interconnected areas including tissue engineering and stem cell biology.

In tissue engineering, I encourage basic and translational research that takes advantage of advances in biology, chemistry, material science and nanotechnology to develop new constructs capable to mimic the structure and function of organs and tissues targeted for their regeneration and repair both in vitro and in vivo. This research is closely associated with the use of specific synthetic and processing methods to rationally design and create biomaterials in according to their final clinical and therapeutic applications including diabetes, osteoporosis and neurodegenerative diseases.

In stem cell biology, I am focus in the development of adult stem cell-derived organoid systems to serve as a new class of biological model for both tissue and organ proxies. These generally aim to recapitulate the main natural features of the stem cell microenvironment or niche which strictly include cell-environment interactions, cell-cell contacts and certain physiological cues generated by tissue-specific cells within the organoid.

Scholarly biography

Valeria graduated from the Faculty of Science of Marche University (IT) in 2005 and worked in the Medical School for two years in the areas  of regulation of human placental development and diseases associated with pregnancy including preeclampsia, diabetes and anaemia. Following that, she has decided moving to the UK where she has completed her MSc in Cell Development Biology and then her PhD at the University of Brighton in 2014. This has been awarded with an international JPE Doctoral Research Award in Biomaterials in 2016. Valeria is currently Research Fellow in Regenerative Medicine at the School of Pharmacy and Biomolecular Sciences and she is involved in numerous successful European research projects of non-commercial and commercial importance. During the last ten years, she has acquired a great amount of knowledge across a varied range of therapeutic areas alongside critical-thinking, research and project-management skills while developing the right abilities to identify and define project requirements, scope and objectives delivering thus each project on time and within budget.  

Supervisory Interests

Willing to supervise PhD students

Education/Academic qualification

PhD, School of Pharmacy and Biomolecular Sci

Master, University of Sussex

Bachelor, Marche Polytechnic University

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Stem Cell Niche Medicine & Life Sciences
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Stem Cells Medicine & Life Sciences
Betaine Medicine & Life Sciences
Hydrogels Chemical Compounds
Chitosan Medicine & Life Sciences
Laminin Medicine & Life Sciences
Tissue engineering Chemical Compounds

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2017 2019

Research Output 2011 2017

  • 5 Article
  • 1 Conference contribution with ISSN or ISBN

Carboxybetaine-modified succinylated chitosan-based beads encourage pancreaticβ-cells (Min-6) to form islet-like spheroids under in vitro conditions

Perugini, V., Best, M., Kumar, S., Guildford, A., Bone, A., Macfarlane, W., Santin, M. & Phillips, G., 30 Dec 2017, In : Journal of Materials Science: Materials in Medicine. 29

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Betaine
Chitosan
Cadherins
Cell Survival
Insulin

Hyperbranched poly(ε -lysine) substratepresenting the laminin sequence YIGSR induces the formation of spheroids in adultbone marrow stem cells

Perugini, V., Meikle, S., Guildford, A. & Santin, M., 12 Dec 2017, In : PLoS ONE.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
tyrosyl-isoleucyl-glycyl-seryl-arginine
Stem Cell Niche
Laminin
Lysine
Stem Cells

Anti-angiogenic Potential of VEGF Blocker Dendron-laden Gellan Gum Hydrogels for Tissue Engineering Applications

Perugini, V., Guildford, A., Silva-Correia, J., Oliveira, J., Meikle, S., Reis, R. & Santin, M., 8 Oct 2016, In : Tissue Engineering and Regenerative Medicine. 12, 2

Research output: Contribution to journalArticleResearchpeer-review

Hydrogels
Tissue engineering
Dendrimers
Vascular Endothelial Growth Factor A
Blood vessels

Functionalisation of methacrylated gellan gum hydrogels by anti-angiogenic dendrons

Perugini, V., Silva-Correia, J., Oliveira, J., Meikle, S., Reis, R. & Santin, M., 3 Sep 2012, In : Journal of Tissue Engineering and Regenerative Medicine. 6, Suppl. 1, p. 193-193 1 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis, characterisation and in vitro anti-angiogenic potential of dendron VEGF blockers

Meikle, S., Perugini, V., Guildford, A. & Santin, M., 8 Dec 2011, In : Macromolecular Bioscience. 11, 12, p. 1761-1765 5 p.

Research output: Contribution to journalArticleResearchpeer-review