If you made any changes in Pure these will be visible here soon.

Personal profile

Research interests

Ion channels are transmembrane spanning proteins that allow the passage of ions from one side of the membrane to the other. These macromolecular proteins play critical roles in numerous physiological functions, such as controlling neuronal excitability. However, abnormal functioning of ion channels can cause disorders including epilepsy, cardiac arrhythmia, ataxia and cancer. My lab uses a multidisciplinary approach to understanding the molecular basis of, and developing therapies for, a spectrum of diseases arising from ion channel dysfunction. This includes research into elucidating the molecular mechanisms behind traditional herbal medicines, particularly the discovery of novel small molecule activators. Other interests include investigating the relationship between channel-transporter or “chansporter” interactions, and how these complexes can be influenced by the metabolic environment, and investigating fungal potassium channels as a strategy for future antifungal therapies.   

Education/Academic qualification

PhD

20122016

Bachelor, University of Portsmouth

20062009

External positions

Postdoctoral Scholar, University of California at Irvine

20162019

Keywords

  • QP Physiology

Fingerprint Dive into the research topics where Rian Manville is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 1 Similar Profiles
Potassium Channels Medicine & Life Sciences
KCNQ Potassium Channels Medicine & Life Sciences
Traditional Medicine Medicine & Life Sciences
Protein Isoforms Medicine & Life Sciences
Ion Channels Medicine & Life Sciences
Anticonvulsants Medicine & Life Sciences
Computer Simulation Medicine & Life Sciences
Voltage-Gated Potassium Channels Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2017 2019

Cilantro leaf harbors a potent potassium channel-activating anticonvulsant

Manville, R. & Abbott, G., 1 Oct 2019, In : The FASEB Journal. 33, 10, p. 11349-11363 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Coriandrum
Potassium Channels
Anticonvulsants
Protein Isoforms
Voltage-Gated Potassium Channels

In silico re-engineering of a neurotransmitter to activate KCNQ potassium channels in an isoform-specific manner

Manville, R. & Abbott, G., 1 Nov 2019, In : Communications Biology. 2, 1, 401.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
KCNQ Potassium Channels
potassium channels
neurotransmitters
glycine (amino acid)
Computer Simulation

KCNQ5 activation is a unifying molecular mechanism shared by genetically and culturally diverse botanical hypotensive folk medicines

Manville, R., van der horst, J., Redford, K., Katz, B., Jepps, T. & Abbott, G., 30 Sep 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 42, p. 21236-21245 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Potassium Channels
Traditional Medicine
Quinolizidines
Sophora
Hypertension

Teamwork: Ion channels and transporters join forces in the brain

Manville, R. & Abbott, G., 5 Apr 2019, In : Neuropharmacology.

Research output: Contribution to journalArticleResearchpeer-review

Ion Channels
Sodium
Brain
KCNQ2 Potassium Channel
Neurotransmitter Transport Proteins

Ancient and modern anticonvulsants act synergistically in a KCNQ potassium channel binding pocket

Manville, R. & Abbott, G., 21 Sep 2018, In : Nature Communications. 9, 3845.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
KCNQ Potassium Channels
Anticonvulsants
Protein Isoforms
Seizures
Voltage-Gated Potassium Channels