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Personal profile

Research interests

Channelopathies

Supervisory Interests

The role of ion channels, transporters, and receptors in disease.

Scholarly biography

I obtained my Ph.D. from the University of Portsmouth in 2016 and worked as a postdoctoral scholar for three years in the laboratory of Geoffrey Abbott at the University of California, Irvine.

Approach to teaching

I like to interact with the audience during my lectures and encourage participation and discussions.

Education/Academic qualification

PhD

20122016

External positions

Postdoctoral Scholar, University of California at Irvine

20162019

Keywords

  • QP Physiology

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Research Output

Acetaminophen (Paracetamol) Metabolites Induce Vasodilation and Hypotension by Activating Kv7 Potassium Channels Directly and Indirectly

Van der Horst, J., Manville, R., Hayes, K., Thomsen, MB., Abbott, G. & Jepps, TA., 19 Mar 2020, In : Arteriosclerosis Thrombosis and Vascular Biology. p. 1207-1219 13 p.

Research output: Contribution to journalArticle

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  • Allosteric regulation of mammalian Na+/I− symporter activity by perchlorate

    Llorente-Esteban, A., Manville, R., Reyna-Neyra, A., Abbott, G., Amzel, L. M. & Carrasco, N., 25 May 2020, In : Nature Structural and Molecular Biology. 27, 6, p. 533-539 7 p.

    Research output: Contribution to journalArticle

  • Hypochlorhydria reduces mortality in heart failure caused by Kcne2 gene deletion

    Lisewski, U., Köhncke, C., Schleussner, L., Purfürst, B., Lee, S. M., De Silva, A., Manville, R., Abbott, G. & Roepke, T., 25 Jun 2020, In : The FASEB Journal. 34, 8, p. 10699-10719 21 p.

    Research output: Contribution to journalArticle

  • Isoform-selective KCNA1 potassium channel openers built from glycine

    Manville, R. & Abbott, G., 13 May 2020, In : Journal of Pharmacology and Experimental Therapeutics. 373, 3, p. 391-401 11 p.

    Research output: Contribution to journalArticle

  • M-channel activation contributes to the anticonvulsant action of the ketone body β-hydroxybutyrate

    Manville, R., Papanikolaou, M. & Abbott, G., 14 Jan 2020, In : Journal of Pharmacology and Experimental Therapeutics. 372, 2, p. 148-156 9 p.

    Research output: Contribution to journalArticle