If you made any changes in Pure these will be visible here soon.

Personal profile

Research interests

Ion channels are transmembrane spanning proteins that allow the passage of ions from one side of the membrane to the other. These macromolecular proteins play critical roles in numerous physiological functions, such as controlling neuronal excitability. However, abnormal functioning of ion channels can cause disorders including epilepsy, cardiac arrhythmia, ataxia and cancer. My lab uses a multidisciplinary approach to understanding the molecular basis of, and developing therapies for, a spectrum of diseases arising from ion channel dysfunction. This includes research into elucidating the molecular mechanisms behind traditional herbal medicines, particularly the discovery of novel small molecule activators. Other interests include investigating the relationship between channel-transporter or “chansporter” interactions, and how these complexes can be influenced by the metabolic environment, and investigating fungal potassium channels as a strategy for future antifungal therapies.   

Education/Academic qualification

PhD

20122016

External positions

Postdoctoral Scholar, University of California at Irvine

20162019

Keywords

  • QP Physiology

Fingerprint Dive into the research topics where Rian Manville is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 1 Similar Profiles

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output

Acetaminophen (Paracetamol) Metabolites Induce Vasodilation and Hypotension by Activating Kv7 Potassium Channels Directly and Indirectly

Van der Horst, J., Manville, R., Hayes, K., Thomsen, MB., Abbott, G. & Jepps, TA., 19 Mar 2020, In : Arteriosclerosis Thrombosis and Vascular Biology. p. 1207-1219 13 p.

Research output: Contribution to journalArticle

File
  • M-channel activation contributes to the anticonvulsant action of the ketone body β-hydroxybutyrate

    Manville, R., Papanikolaou, M. & Abbott, G., 14 Jan 2020, In : Journal of Pharmacology and Experimental Therapeutics. 372, 2, p. 148-156 9 p.

    Research output: Contribution to journalArticle

  • Potassium channels act as chemosensors for solute transporters

    Manville, R. & Abbott, G., 28 Feb 2020, In : Communications Biology. 3, 90.

    Research output: Contribution to journalArticle

    Open Access
    File

    Cilantro leaf harbors a potent potassium channel-activating anticonvulsant

    Manville, R. & Abbott, G., 1 Oct 2019, In : The FASEB Journal. 33, 10, p. 11349-11363 15 p.

    Research output: Contribution to journalArticle