Personal profile
Research interests
Molecular neuroscientist looking into Cancer-Related Cognitive Impairment (CRCI)
Scholarly biography
I am currently working in the Centre for Stress and Age-Related disease at the University of Brighton. My PhD project tackles a key question in brain research, i.e. how stress can induce cognitive dysfunction. More specifically, the project aims to identify the mechanisms underlying cancer-related cognitive impairment. Cognitive changes are common in cancer patients and survivors with non-central nervous system tumours. The changes have been predominantly blamed on chemotherapy-related toxicities. However, researchers and clinicians recently found that up to 40% of patients show a decreased cognitive performance prior to receiving any treatments. This suggests that other factors contribute to the cognitive impairment observed cancer patients. Therefore, this projects aims to identify the impact of diagnosis-associated psychological stress and tumour-associated factors on cognitive function.
I was awarded with a PhD studentship from the University of Brighton in 2016 after completing my MSc project in neuroregeneration following spinal cord injury at the University of Hasselt (Belguim) and a genetics-based Erasmus+ internship at La Paz University Hospital, Madrid (Spain)
Education/Academic qualification
Master, Biomedical Sciences, Hasselt University
Award Date: 20 Jun 2016
Master, ErasmusPlus, Universidad Autónoma de Madrid
Award Date: 25 May 2015
Bachelor, Biomedical Sciences , Hasselt University
Award Date: 20 Aug 2014
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Collaborations and top research areas from the last five years
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Impact of Psychological Stress and Spontaneous Tumour Regression on the Hippocampal Proteome in a Mouse Model of Breast Cancer
Mampay, M., Al‐Hity, G., Rolle, S. O., Alzboon, W., Stewart, N. A., Flint, M. S. & Sheridan, G. K., 2 Apr 2025, In: Journal of Neurochemistry. 169, 4, 35 p., e70052.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Propranolol reduces IFN-γ driven PD-L1 immunosuppression and improves anti-tumour immunity in ovarian cancer
Falcinelli, M., Al-Hity, G., Baron, S., Mampay, M., Allen, M. C., Samuels, M., Jones, W., Cilibrasi, C., Flaherty, R. L., Giamas, G., Thaker, P. H. & Flint, M. S., 14 Feb 2023, In: Brain Behavior and Immunity. 110, p. 1-12 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
An integrated framework for quantifying immune-tumour interactions in a 3D co-culture model
Al-Hity, G. A. W., Yang, F. W., Campillo-Funollet, E., Greenstein, A. E., Hunt, H., Mampay, M., Intabli, H., Falcinelli, M., Madzvamuse, A., Venkataraman, C. & Flint, M., 24 Jun 2021, In: Communications Biology. 4, 1, p. 1-12 12 p., 781.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Tumour brain: pre-treatment cognitive and affective disorders caused by peripheral cancers
Mampay, M., Flint, M. & Sheridan, G., 24 May 2021, In: British Journal of Pharmacology. 178, 19, p. 3977-3996 20 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
REST: An epigenetic regulator of neuronal stress responses in the young and ageing brain
Mampay, M. & Sheridan, G. K., 17 Apr 2019, In: Frontiers in Neuroendocrinology. 53, 100744.Research output: Contribution to journal › Literature review › peer-review