Personal profile
Research interests
My academic career spans over 20 years of sustained research excellence, interdisciplinary collaboration, and research‑informed educational leadership. Trained as a biomedical scientist, my research portfolio combines internationally recognised disciplinary research with an increasingly influential programme of pedagogic research focused on reducing degree awarding gaps and improving equity of outcomes in higher education.
My disciplinary research has contributed to advances in vascular biology, inflammatory signalling, pharmacology, and computational health analytics. I have authored 39 peer‑reviewed research papers, 9 review articles and a book chapter, and over 2,200 citations (h‑index 22). A defining feature of this work is interdisciplinary collaboration, particularly in the application of computational and AI/ML approaches to real‑world clinical datasets. Notably, I co‑led the development of machine‑learning tools predicting COVID‑19 severity and mortality using routine blood biomarkers, resulting in high‑impact publications, international recognition, a first‑prize hackathon award, and significant public engagement through national and international media. Across my disciplinary work, my approach emphasises methodological rigour, translational relevance, and collaborative problem‑solving.
Alongside this, I have developed a coherent and data‑driven programme of pedagogic research focused on assessment design, curriculum structure, and student success. This work is premised on the principle that degree awarding gaps are shaped by institutional practices rather than student deficit. My recent research evaluated a suite of inclusive assessment interventions in undergraduate Biosciences, including SMART worksheets, laboratory simulations, and transparent rubric‑based marking. Using longitudinal analysis across three academic years and nearly 700 students, this work demonstrated a statistically significant reduction in attainment gaps between students from lower‑ and higher‑income backgrounds at Level 4, narrowing from –6.3% to –1.7%. Similar reductions were observed across ethnic groups, alongside improved likelihood of achieving good honours outcomes.
This research evidences that structural changes to assessment and feedback — without lowering academic standards — can meaningfully improve confidence, continuation, and equity of outcomes. The work was recognised nationally through the LearnSci Teaching Innovation Prize and is now informing wider curriculum reform across the School of Applied Sciences. As Associate Dean (Education and Student Experience), I am uniquely positioned to scale pedagogic research into institutional practice, embedding evidence‑based innovations across more than 30 modules and delivering measurable improvements in continuation, completion, and student satisfaction metrics.
Externally, I contribute to sector‑level leadership through senior roles with the Institute of Biomedical Science, including Chair of the HEI Specialist Advisory Panel and Chair of national academic sessions, alongside external examining at Imperial College London. I am regularly invited to present on inclusive assessment, educational innovation, and equity of outcomes.
Overall, my research profile is defined by coherence across disciplinary science, pedagogic scholarship, and educational leadership. Whether advancing biomedical research or transforming assessment practices to close degree awarding gaps, my work is underpinned by rigorous data analysis, interdisciplinary collaboration, and a commitment to research with clear academic and societal impact.
Supervisory Interests
1. Assessment Design and Degree Awarding Gaps
- Longitudinal, multi‑institutional analysis of how different assessment formats influence awarding gaps
- Causal modelling of assessment transparency, feedback mechanisms, and student outcomes
- Scaling inclusive assessment practices across disciplines
2. Learning Analytics and Student Success
- Predictive modelling of continuation and completion using assessment and engagement data
- Equity‑focused learning analytics: identifying structural rather than behavioural risk factors
- Ethical use of AI in monitoring student engagement and attendance
3. Digital Pedagogies in Laboratory‑Based Disciplines
- Impact of lab simulations and preparatory tools on attainment and confidence
- Differential effects of digital scaffolding across demographic groups
- Blended laboratory models and inclusivity
Education/Academic qualification
CMI level 3 Award in Principles of Management and Leadership
Award Date: 6 Apr 2026
Senior Fellow HEA, The Higher Education Academy (HEA)
Award Date: 17 Jun 2024
Fellow of the IBMS, Institute of Biomedical Science
Award Date: 1 Jan 2023
Fellow of the HEA, The Higher Education Academy (HEA)
Award Date: 6 Oct 2014
Postgraduate Certificate Learning and Teaching in Higher Education, University of Hertfordshire
Award Date: 19 Sept 2014
PhD, The Role of PLC isoforms in the Regulating Differentiated function in Vascular Smooth Muscle, Imperial College London
1 Oct 2000 → 1 Oct 2003
Award Date: 30 Nov 2003
Bachelor, Biological Sciences with Microbiology, University of Warwick
Award Date: 11 Jul 1996
External positions
Chair Special Advisory panel (Education), Institute of Biomedical Science
Mar 2026 → …
External Examiner, Imperial College London
10 Oct 2024 → 9 Oct 2028
Deputy Chair Special Advisory Group (Academic), Institute of Biomedical Science
Jun 2024 → Nov 2025
Non-Accredited Degree Assessor , Institute of Biomedical Science
21 Jul 2023 → …
Co-Chair of the Effective Feedback and Assessments Community Group
22 Jun 2022 → …
Senior Lecturer Pharmacology, University of Hertfordshire
2013 → 2018
Senior Post Doctoral Research Fellow, NHLI, Imperial College London
2007 → 2013
Post-Doctoral Research Associate, The William Harvey Research Institute
2004 → 2007
Post-Doctoral Research Assistant, NHLI, Imperial College London
2002 → 2004
Research Assistant, Hatter Institute
1998 → 2000
Research Assistant, Wellcome Trust for Human Genetics, University of Oxford
1997 → 1998
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Collaborations and top research areas from the last five years
Projects
- 1 Finished
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Tabernanthe iboga (TiAE) in isolated pancreatic islets of Langerhan
MacKenzie, L. (PI), Macfarlane, W. (CoI), Lione, L. (CoI), BADING-TAIKA, B. (PI), Zloh, M. (CoI) & Souza, A. (PI)
1/01/14 → 31/12/18
Project: Research
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Effectiveness of Antimicrobial Photodynamic Therapy Versus Doxycycline in the Treatment of Periodontitis on Glycaemic Control and Periodontal Parameters in Adults with Type 2 Diabetes Mellitus.
Abbott, M. & Mackenzie, L. S., 22 Sept 2024, MedRxiv, 42 p.Research output: Working paper › Preprint
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A robust COVID‑19 mortality prediction calculator based on Lymphocyte count, Urea, C‑Reactive Protein, Age and Sex (LUCAS) with chest X‑rays
Ray, S., Banerjee, A., Swift, A. J., Fanstone, J., Mamalakis, M., Vorselaars, B., Wilkie, C., Cole, J., Mackenzie, L. S. & Weeks, S., 29 Oct 2022, In: Scientific Reports. 12, 1, 14 p., 18220.Research output: Contribution to journal › Article › peer-review
Open Access -
Development of a Mortality Prediction Model in Hospitalised SARS-CoV-2 Positive Patients Based on Routine Kidney Biomarkers
Boss, A., Banerjee, A., Mamalakis, M., Ray, S., Swift, A. J., Wilkie, C., Fanstone, J., Vorselaars, B., Cole, J., Weeks, S. & Mackenzie, L. S., 30 Jun 2022, In: International Journal of Molecular Sciences. 23, 13, 13 p., 7260.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
A simplified risk tool, LUCAS, which predicts the outcome for patients with SARS-CoV-2 also predicts survival from Influenza A and Influenza B infections.
Wilkie, C., Ray, S., Banerjee, A., Mamalakis, M., Swift, A. J., Vorselaars, B., Fanstone, J., Weeks, S. & Mackenzie, L. S., 7 Sept 2021.Research output: Contribution to conference › Abstract › peer-review
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Can kidney function be used to predict survival of COVID-19 in hospitals? Predictive modelling in a retrospective cohort study.
Mackenzie, L. S., Wilkie, C., Ray, S., Banerjee, A., Mamalakis, M., Swift, A. J., Vorselaars, B., Fanstone, J. & Weeks, S., 7 Sept 2021.Research output: Contribution to conference › Abstract › peer-review