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Personal profile

Research interests

My main area of research interest is in the chemistry of human ageing including

  • Synthetic chemistry for the discovery and evaluation of compounds that intervene in and remediate age-related degenerative processes
  • Discovery and design of compounds that abrogate the negative effects of cellular senescence
  • Bioanalytical evaluation of age related changes

My research is focused on the chemical analysis of, and intervention in, ageing processes. Building on postdoctoral experience in mechanistic enzymology (where I discovered the first catalytic antibody lactamase generated in response to a synthetic compound), I developed the first mathematical model to explain why some, but not all, tissues in Werner’s Syndrome patients show a premature degenerative phenotype.  My work has since progressed to using experimental models to investigate putative causal mechanisms of ageing. 

My EPSRC/BBSRC SPARC funded project resulted in the first demonstration that age-related chemical changes in Drosophila are consistent with the “Green Theory” of ageing. More, recently we demonstrated that the highly-publicised postulated anti-ageing compound, Resveratrol, causes premature cellular senescence in primary cells in vitro.  

My latest research includes the development of a simple synthesis of novel “Resveralogues”. We are now evaluating our panel of over 40 compounds, in collaboration with multiple international laboratories, to determine the chemical features underlying the beneficial activities of stilbene molecules whilst abrogating the detrimental ones. The structure-activity relationships (SAR) we have developed are now informing our second generation compound designs.

Approach to teaching

As an analytical chemistry lecturer, I consider it my role to show students how to approach the subject, and to facilitate development of their chemical problem solving and numerical skills. My lectures are therefore a mixture of explanation of fundamental concepts, and workshop activities to practice applying the concepts. These are complemented by laboratory classes putting it all into practice. I introduce primary research articles from year 1 and expect the final year project students to undertake original research with me. 

I tell my students “In year 1 we show you the tools, in year 2 you have to choose how to use them, and in year 3 you apply them to something that has never been done before.”

Supervisory Interests

The effect of polyphenols and synthetic analogues of these on human ageing, with a particular focus on cellular senescence. Projects are offered in synthetic chemistry, cell biology and multidisciiplinary combinations of these.

Education/Academic qualification

PhD, University of Bristol

1 Oct 199330 Sep 1996

Bachelor, University of Bristol

1 Oct 198930 Jun 1992

External positions

Treasurer

1 Aug 201631 Jul 2020

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2002 2018

FOXO1 and ETV6 genes may represent novel regulators of splicing factor expression in cellular senescence

Latorre, E., Ostler, E. L., Faragher, R. G. A. & Harries, L. W., 8 Aug 2018, In : The FASEB Journal.

Research output: Contribution to journalArticleResearchpeer-review

Cell Aging
MAP Kinase Signaling System
Genes
Fibroblasts
Gene Knockdown Techniques

Senescence in the aging process

Faragher, R., McArdle, A., Willows, A. & Ostler, E., 25 Jul 2017, In : F1000 Research. 6

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Phenotype
Transcriptome

Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence

Latorre, E., Birar, V., Sheerin, A., Jeynes, C. C., Hooper, A., Dawe, H., Melzer, D., Cox, L., Faragher, R., Ostler, E. & Harries, L. W., 17 Oct 2017, In : BMC Cell Biology. 18

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Cell Aging
Cell Cycle
Messenger RNA
Telomere
Fibroblasts

A facile, stereoselective, one-pot synthesis of resveratrol derivatives

Birar, V., Sheerin, A., Milkovicova, J., Faragher, R. & Ostler, E., 20 May 2015, In : Chemistry Central Journal. 9

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Derivatives
Stilbenes
Electrons
Purification
Anti-Inflammatory Agents

Editorial: a systematic end to "muddling through"?

Faragher, R. (ed.) & Ostler, E. (ed.), 28 Feb 2012, UK. 2 p.

Research output: Book/ReportBook - editedResearch

Activities 1996 2016

  • 1 Editorial work
  • 1 Membership of professional body
  • 1 Personal board membership of professional/academic bodies
  • 1 External funding peer-review

Royal Society of Chemistry, Heads of CHemistry UK (External organisation)

Lizzy Ostler (Chair)
1 Jul 20161 Jul 2019

Activity: External boards and professional/academic bodiesPersonal board membership of professional/academic bodies

Vice Chair

Lizzy Ostler (Panel Chair)
1 Jan 2013

Activity: External funding peer-review

Chemistry Central Journal (Journal)

Lizzy Ostler (Reviewer)
1 Jan 2006

Activity: Publication peer-review and editorial workEditorial work

Royal Society of Chemistry (External organisation)

Lizzy Ostler (Chair)
1 Jan 1996

Activity: External boards and professional/academic bodiesMembership of professional body