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Research Output 1994 2019

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2002

NFkappaB1 (p50)-deficient mice are not susceptible to multiple low-dose streptozotocin-induced diabetes

Mabley, J., Hasko, G., Liaudet, L., Soriano, F. G., Southan, G. J., Salzman, A. L. & Szabo, C., 2002, In : Journal of Endocrinology. 173, 3, p. 457-464 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Nicotine reduces the incidence of type I diabetes in mice

Mabley, J., Pacher, P., Southan, G. J., Salzman, A. L. & Szabo, C., Mar 2002, In : Journal of Pharmacology and Experimental Therapeutics. 300, 3, p. 876-881 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Novel phenanthridinone inhibitors of poly(adenosine 5'-diphosphate-ribose) synthetase: Potent cytoprotective and antishock agents

Jagtap, P., Soriano, F. G., Virag, L., Liaudet, L., Mabley, J., Szabo, E., Hasko, G., Marton, A., Lorigados, C. B., Gallyas, F., Sumegi, B., Hoyt, D. G., Baloglu, E., VanDuzer, J. H., Salzman, A. L., Southan, G. J. & Szabo, C., May 2002, In : Critical Care Medicine. 30, 5, p. 1071-1082 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Part I: Pathogenetic role of peroxynitrite in the development of diabetes and diabetic vascular complications: studies with FP15, a novel potent peroxynitrite decomposition catalyst

Szabo, C., Mabley, J., Moeller, S. M., Shimanovich, R., Pacher, P., Virag, L., Soriano, F. G., Van Duzer, J. H., Williams, W., Salzmann, A. L. & Groves, J. T., Oct 2002, In : Molecular Medicine. 8, 10, p. 571-580 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Part II: beneficial effects of the peroxynitrite decomposition catalyst FP15 in murine models of arthritis and colitis

Mabley, J., Liaudet, L., Pacher, P., Southan, G. J., Salzman, A. L. & Szabo, C., Oct 2002, In : Molecular Medicine. 8, 10, p. 581-590 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Pharmacologic inhibition of poly(adenosine diphosphate-ribose) polymerase may represent a novel therapeutic approach in chronic heart failure

Pacher, P., Liaudet, L., Mabley, J., Komjati, K. & Szabo, C., Sep 2002, In : Journal of the American College of Cardiology. 40, 5, p. 1006-1016 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Adenosine Diphosphate Ribose
Poly Adenosine Diphosphate Ribose
Heart Failure
Blood Vessels
Myocardial Reperfusion Injury

Poly(ADP-ribose) polymerase is a regulator of chemokine production: relevance for the pathogenesis of shock and inflammation

Hasko, G., Mabley, J., Nemeth, Z. H., Pacher, P., Deitch, E. A. & Szabo, C., May 2002, In : Molecular Medicine. 8, 5, p. 283-289 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Resistance to acute septic peritonitis in poly(ADP-ribose) polymerase-1-deficient mice

Soriano, F. G., Liaudet, L., Szabo, E., Virag, L., Mabley, J., Pacher, P. & Szabo, C., Apr 2002, In : Shock. 17, 4, p. 286-292 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Role of poly(ADP-ribose) polymerase activation in endotoxin-induced cardiac collapse in rodents

Pacher, P., Cziraki, A., Mabley, J., Liaudet, L., Papp, L. & Szabo, C., Dec 2002, In : Biochemical Pharmacology. 64, 12, p. 1785-1791 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Poly(ADP-ribose) Polymerases
Endotoxins
Rodentia
Cardiovascular System
Lipopolysaccharides

The flagellin-TLR5 axis: therapeutic opportunities

Liaudet, L., Deb, A., Pacher, P., Mabley, J., Murthy, K. G. K., Salzman, A. L. & Szabo, C., Sep 2002, In : Drug News and Perspectives. 15, 7, p. 397-409 13 p.

Research output: Contribution to journalArticleResearchpeer-review

The role of poly(ADP-Ribose) polymerase activation in the development of myocardial and endothelial dysfunction in diabetes

Pacher, P., Liaudet, L., Soriano, F. G., Mabley, J., Szabo, E. & Szabo, C., 2002, In : Diabetes. 51, p. 514-521 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Poly(ADP-ribose) Polymerases
Streptozocin
Hyperglycemia
Diabetic Cardiomyopathies
Diabetic Angiopathies
2001

An inhibitor of inducible nitric oxide synthase and scavenger of peroxynitrite prevents diabetes development in NOD mice

Suarez-Pinzon, W. L., Mabley, J., Strynadka, K., Power, R. F., Szabo, C. & Rabinovitch, A., Jun 2001, In : Journal of Autoimmunity. 16, 4, p. 449-455 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Inbred NOD Mouse
Peroxynitrous Acid
Nitric Oxide Synthase Type II
Islets of Langerhans
Nitric Oxide

Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase

Mabley, J., Jagtap, P., Perretti, M., Getting, S. J., Salzman, A. L., Virag, L., Szabo, E., Soriano, F. G., Liaudet, L., Abdelkarim, G. E., Hasko, G., Marton, A., Southan, G. J. & Szabo, C., Dec 2001, In : Inflammation Research. 50, 11, p. 561-569 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation

Soriano, F. G., Virag, L., Jagtap, P., Szabo, E., Mabley, J., Liaudet, L., Marton, A., Hoyt, D. G., Murthy, K. G. K., Salzman, A. L., Southan, G. J. & Szabo, C., Jan 2001, In : Nature Medicine. 7, 1, p. 108-113 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Poly(ADP-ribose) Polymerases
Hyperglycemia
Blood Vessels
Reactive Nitrogen Species
Glucose

Inhibition of poly (ADP-ribose) synthetase by gene disruption or inhibition with 5-iodo-6-amino-1,2-benzopyrone protects mice from multiple-low-dose-streptozotocin-induced diabetes

Mabley, J., Suarez-Pinzon, W. L., Hasko, G., Salzman, A. L., Rabinovitch, A., Kun, E. & Szabo, C., Jul 2001, In : British Journal of Pharmacology. 133, 6, p. 909-919 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibition of the Na(+)/H(+) antiporter suppresses IL-12 p40 production by mouse macrophages

Nemeth, Z. H., Mabley, J., Deitch, E. A., Szabo, C. & Hasko, G., Jun 2001, In : Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1539, 3, p. 233-242 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Sodium-Hydrogen Antiporter
Amiloride
Interleukin-12
Macrophages
Interferons

Inosine reduces systemic inflammation and improves survival in septic shock induced by cecal ligation and puncture

Liaudet, L., Mabley, J., Soriano, F. G., Pacher, P., Marton, A., Hasko, G. & Szabo, C., Oct 2001, In : American Journal of Respiratory and Critical Care Medicine. 164, 7, p. 1213-1220 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Inosine
Septic Shock
Punctures
Ligation
Inflammation

Peroxynitrite is a mediator of cytokine-induced destruction of human pancreatic islet beta cells

Lakey, J. R. T., Suarez-Pinzon, W. L., Strynadka, K., Korbutt, G. S., Rajotte, R., Mabley, J., Szabo, C. & Rabinovitch, A., 2001, In : Laboratory Investigation. 81, 12, p. 1683-1692 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Peroxynitrous Acid
Insulin-Secreting Cells
Islets of Langerhans
Cytokines
Nitric Oxide

Rapid reversal of the diabetic endothelial dysfunction by pharmacological inhibition of poly(ADP-Ribose) polymerase

Soriano, F. G., Pacher, P., Mabley, J., Liaudet, L. & Szabo, C., 2001, In : Circulation Research. 89, 8, p. 684-691 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2000

Inosine inhibits inflammatory cytokine production by a posttranscriptional mechanism and protects against endotoxin-induced shock

Hasko, G., Kuhel, D. G., Nemeth, Z. H., Mabley, J., Stachlewitz, R. F., Virag, L., Lohinai, Z., Southan, G. J., Salzman, A. L. & Szabo, C., 15 Jan 2000, In : Journal of Immunology. 164, 2, p. 1013-1019 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Inosine
Endotoxins
Shock
Cytokines
Purines
1999

Glucagon decreases cytokine induction of nitric oxide synthase and action on insulin secretion in RIN5F cells and rat and human islets of Langerhans

Belin, V., Mabley, J., James, R. F. L., Swift, S. M., Clayton, H. A., Titheradge, M. A. & Green, I. C., 31 Aug 1999, In : Cytokine. 11, 8, p. 585-592 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Glucagon
Islets of Langerhans
Nitric Oxide Synthase
Insulin
Cytokines
1998

Growth factor protection against cytokine-induced apoptosis in neonatal rat islets of Langerhans: role of Fas

Harrison, M., Dunger, A. M., Berg, S., Mabley, J., John, N., Green, M. H. L. & Green, I. C., 18 Sep 1998, In : Febs Letters. 435, 2-3, p. 207-210 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Islets of Langerhans
Intercellular Signaling Peptides and Proteins
Apoptosis
Cytokines
Cytoprotection
1997

Superoxide, nitric oxide, peroxynitrite and cytokine combinations all cause functional impairment and morphological changes in rat islets of Langerhans and insulin secreting cell lines, but dictate cell death by different mechanisms

Di Matteo, M. A., Loweth, A. C., Thomas, S., Mabley, J., Morgan, N. G., Thorpe, J. & Green, I. C., 31 Dec 1997, In : Apoptosis. 2, 2, p. 164-177 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Peroxynitrous Acid
Insulin-Secreting Cells
Islets of Langerhans
Superoxides
Nitric Oxide

Transforming growth factor beta 1 prevents cytokine-mediated inhibitory effects and induction of nitric oxide synthase in the RINm5F insulin-containing beta-cell line

Mabley, J., Cunningham, J., John, N., Di Matteo, M. A. & Green, I. C., 31 Dec 1997, In : Journal of Endocrinology. 155, 3, p. 567-575 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Nitric Oxide Synthase
Transforming Growth Factor beta
Insulin
Cytokines
Cell Line
1994

Effects of cytokines and nitric oxide donors on insulin secretion, cyclic GMP and DNA damage: relation to nitric oxide production

Green, I. C., Cunningham, J., Delaney, C. A., Elphick, M. R., Mabley, J. & Green, M. H. L., 28 Feb 1994, In : Biochemical Society Transactions. 22, 1, p. 30-37 8 p.

Research output: Contribution to journalArticleResearchpeer-review

The effect of nitric oxide donors on insulin secretion, cyclic GMP and cyclic AMP in rat islets of Langerhans and the insulin-secreting cell lines HIT-T15 and RINm5F

Cunningham, J., Mabley, J., Delaney, C. A. & Green, I. C., 30 Jun 1994, In : Molecular and Cellular Endocrinology. 102, 1-2, p. 23-29 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Nitric Oxide Donors
Insulin-Secreting Cells
Hydroxylamine
Islets of Langerhans
Cyclic AMP